Consulta: creatorFacets:"VON BERNHARDI,ROMMY"
Registros recuperados: 2
Data/hora: 08/06/2024 12:56:05

Microglia ­ astrocyte interaction in Alzheimer's disease: friends or foes for the nervous system?
Provedor de dados: 48
Autores: VON BERNHARDI,ROMMY; RAMIREZ,GIGLIOLA.
Brain glial cells secrete several molecules that can modulate the survival of neurons after various types of damage to the CNS. Activated microglia and astrocytes closely associate to amyloid plaques in Alzheimer Disease (AD). They could have a role in the neurotoxicity observed in AD because of the inflammatory reaction they generate. There is controversy regarding the individual part played by the different glial cells, and the interrelationships between them. Both astrocytes and microglia produce several cytokines involved in the inflammatory reaction. Moreover, the same cytokines may have different effects, depending on their concentration and the type of cells in the vicinity. In turn, the events occurring in response to injury may lead to changes in...
Tipo: Journal article
Palavras-chave: Apoptosis; SS-amyloid; Cell activation; Inflammatory process; Neurotoxicity; Senile plaques.
Ano: 2001
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602001000200017

Oligodendrocytes damage in Alzheimer's disease: Beta amyloid toxicity and inflammation
Provedor de dados: 48
Autores: ROTH,ALEJANDRO D; RAMÍREZ,GIGLIOLA; ALARCÓN,RODRIGO; VON BERNHARDI,ROMMY.
Research on Alzheimer's disease (AD) focuses mainly on neuronal death and synaptic impairment induced by &amp;#946;-Amyloid peptide (A&amp;#946;), events at least partially mediated by astrocyte and microglia activation. However, substantial white matter damage and its consequences on brain function warrant the study of oligodendrocytes participation in the pathogenesis and progression of AD. Here, we analyze reports on oligodendrocytes' compromise in AD and discuss some experimental data indicative of A&amp;#946; toxicity in culture. We observed that 1 &amp;#956;M of fibrilogenic A&amp;#946; peptide damages oligodendrocytes in vitro; while pro-inflammatory molecules (1 &amp;#956;g/ml LPS + 1 ng/ml IFN&amp;#947;) or the presence of astrocytes reduced the...
Tipo: Journal article
Palavras-chave: Cell death; Glial cells; Pro-inflammatory cytokines.
Ano: 2005
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602005000400011