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Characterization and Function of the First Antibiotic Isolated from a Vent Organism: The Extremophile Metazoan Alvinella pompejana
Provedor de dados: 5
Autores: Tasiemski, Aurelie; Jung, Sascha; Boidin-wichlacz, Celine; Jollivet, Didier; Cuvillier-hot, Virginie; Pradillon, Florence; Vetriani, Costantino; Hecht, Oliver; Soennichsen, Frank D.; Gelhaus, Christoph; Hung, Chien-wen; Tholey, Andreas; Leippe, Matthias; Groetzinger, Joachim; Gaill, Francoise.
The emblematic hydrothermal worm Alvinella pompejana is one of the most thermo tolerant animal known on Earth. It relies on a symbiotic association offering a unique opportunity to discover biochemical adaptations that allow animals to thrive in such a hostile habitat. Here, by studying the Pompeii worm, we report on the discovery of the first antibiotic peptide from a deep-sea organism, namely alvinellacin. After purification and peptide sequencing, both the gene and the peptide tertiary structures were elucidated. As epibionts are not cultivated so far and because of lethal decompression effects upon Alvinella sampling, we developed shipboard biological assays to demonstrate that in addition to act in the first line of defense against microbial invasion,...
Tipo: Text
Ano: 2014
URL: http://archimer.ifremer.fr/doc/00219/33052/31517.pdf