Consulta: creatorFacets:"Vieira,J.G.H."
Registros recuperados: 11
Data/hora: 02/06/2024 11:32:17

Pituitary glycoprotein hormone a-subunit secretion by cirrhotic patients
Provedor de dados: Brazilian Journal of Medical and Biological Research
Autores: Oliveira,M.C.; Pizarro,C.B.; Cassal,A.; Cremonese,R.; Vieira,J.G.H.
Secretion of the &lt;FONT FACE="Symbol"&gt;a&lt;/font&gt;-subunit of pituitary glycoprotein hormones usually follows the secretion of intact gonadotropins and is increased in gonadal failure and decreased in isolated gonadotropin deficiency. The aim of the present study was to determine the levels of the &lt;FONT FACE="Symbol"&gt;a&lt;/font&gt;-subunit in the serum of patients with cirrhosis of the liver and to compare the results obtained for eugonadal cirrhotic patients with those obtained for cirrhotic patients with hypogonadotropic hypogonadism. Forty-seven of 63 patients with cirrhosis (74.6%) presented hypogonadism (which was central in 45 cases and primary in 2), 7 were eugonadal, and 9 women were in normal menopause. The serum &lt;FONT...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: &lt; FONT FACE=Symbol&gt; A&lt; /font&gt; -subunit pituitary gonadotropins hypogonadism cirrhosis.
Ano: 1999
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000100011

Serum leptin concentration during puberty in healthy nonobese adolescents
Provedor de dados: Brazilian Journal of Medical and Biological Research
Autores: Brandão,C.M.A.; Lombardi,M.T.; Nishida,S.K.; Hauache,O.M.; Vieira,J.G.H.
Data obtained during the past five years have indicated that there are important age- and gender-based differences in the regulation and action of leptin in humans. To study the physiological changes of leptin during puberty in both sexes, and its relationship with body composition and sexual maturation, we measured leptin concentrations in 175 healthy adolescents (80 girls, 95 boys, 10-18 years of age), representing all pubertal stages. We excluded individuals with a body mass index (BMI) below the 5thor above the 95th percentile relative to age. Serum concentrations of leptin were determined by a monoclonal antibody-based immunofluorimetric assay, developed in our laboratory. Body composition was determined by dual-energy X-ray absorptiometry. Pubertal...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Leptin; Pubertal development; Body composition.
Ano: 2003
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003001000003

Usefulness of a rapid immunometric assay for intraoperative parathyroid hormone measurements
Provedor de dados: Brazilian Journal of Medical and Biological Research
Autores: Ohe,M.N.; Santos,R.O.; Kunii,I.S.; Carvalho,A.B.; Abrahão,M.; Cervantes,O.; Lazaretti-Castro,M.; Vieira,J.G.H.
Intraoperative parathyroid hormone (IO-PTH) measurements have been proposed to improve operative success rates in primary, secondary and tertiary hyperparathyroidism (PHP, SHP and THP). Thirty-one patients requiring parathyroidectomy were evaluated retrospectively from June 2000 to January 2002. Sixteen had PHP, 7 SHP and 8 THP. Serum samples were taken at times 0 (before resection), 10, 20 and 30 min after resection of each abnormal parathyroid gland. Samples from 28 patients were frozen at -70ºC for subsequent tests, whereas samples from three patients were tested while surgery was being performed. IO-PTH was measured using the Elecsys immunochemiluminometric assay (Roche, Mannheim, Germany). The time necessary to perform the assay was 9 min. All samples...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Parathyroid hormone; Intraoperative PTH measurement; Primary hyperparathyroidism; Secondary hyperparathyroidism; Tertiary hyperparathyroidism.
Ano: 2003
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003000600006

Changes in clinical and laboratory findings at the time of diagnosis of primary hyperparathyroidism in a University Hospital in São Paulo from 1985 to 2002
Provedor de dados: Brazilian Journal of Medical and Biological Research
Autores: Ohe,M.N.; Santos,R.O.; Barros,E.R.; Lage,A.; Kunii,I.S.; Abrahão,M.; Cervantes,O.; Hauache,O.M.; Lazaretti-Castro,M.; Vieira,J.G.H.
In contrast to most developed countries, most patients with primary hyperparathyroidism in Brazil are still symptomatic at diagnosis. However, we have been observing a change in this pattern, especially in the last few years. We evaluated 104 patients, 77 females and 27 males aged 11-79 years (mean: 54.4 years), diagnosed between 1985 and 2002 at a University Hospital. Diagnosis was made on the basis of clinical findings and of high total and/or ionized calcium levels, high or inappropriate levels of intact parathyroid hormone and of surgical findings in 80 patients. Patients were divided into three groups, i.e., patients diagnosed from 1985 to 1989, patients diagnosed from 1990 to 1994, and patients diagnosed from 1995 to 2002. The number of new cases...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Primary hyperparathyroidism; Hypercalcemia; Clinical presentation; Asymptomatic primary hyperparathyroidism; Parathyroid hormone; Hyperparathyroidism.
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005000900013

Analysis of the diagnostic presentation profile, parathyroidectomy indication and bone mineral density follow-up of Brazilian patients with primary hyperparathyroidism
Provedor de dados: Brazilian Journal of Medical and Biological Research
Autores: Oliveira,U.E.M.; Ohe,M.N.; Santos,R.O.; Cervantes,O.; Abrahão,M.; Lazaretti-Castro,M.; Vieira,J.G.H.; Hauache,O.M.
Primary hyperparathyroidism is an endocrine disorder with variable clinical expression, frequently presenting as asymptomatic hypercalcemia in Western countries but still predominantly as a symptomatic disease in developing countries. The objective of this retrospective study was to describe the diagnostic presentation profile, parathyroidectomy indication and post-surgical bone mineral density follow-up of patients with primary hyperparathyroidism seen at a university hospital. We found 115 patients (92 women, median age 56 years) with primary hyperparathyroidism diagnosed during the last 20 years. We defined symptomatic patients based on the presence of any classical symptom affecting bone, kidney or the neuromuscular system. Surgical criteria followed...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Primary hyperparathyroidism; Hypercalcemia; Clinical presentation; Parathyroidectomy; Bone mineral density.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007000400010

Response to an oral calcium load in nephrolithiasis patients with fluctuating parathyroid hormone and ionized calcium levels
Provedor de dados: Brazilian Journal of Medical and Biological Research
Autores: Gomes,S.A.; Lage,A.; Lazaretti-Castro,M.; Vieira,J.G.H.; Heilberg,I.P.
the response to an oral calcium load test was assessed in 17 hypercalciuric nephrolithiasis patients who presented elevated parathyroid hormone (PTH) irrespective of the ionized calcium (sCa2+) levels. Blood samples were collected at baseline (0 min) and at 60 and 180 min after 1 g calcium load for serum PTH, total calcium, sCa2+, and 1.25(OH)2D3 determinations. According to the sCa2+ level at baseline, patients were classified as normocalcemic (N = 9) or hypercalcemic (N = 8). Six healthy subjects were also evaluated as controls. Bone mineral density was reduced in 14/17 patients. In the normocalcemic group, mean PTH levels at 0, 60 and 180 min (95 ± 76, 56 ± 40, 57 ± 45 pg/ml, respectively) did not differ from the hypercalcemic group (130 ± 75, 68 ± 35,...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Parathyroid hormone; Calcium; Hyperparathyroidism; Hypercalciuria; Nephrolithiasis; Bone mineral density.
Ano: 2004
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2004000900013

Bone mineral density in young women of the city of São Paulo, Brazil: correlation with both collagen type I alpha 1 gene polymorphism and clinical aspects
Provedor de dados: Brazilian Journal of Medical and Biological Research
Autores: Barros,E.R.; Kasamatsu,T.S.; Ramalho,A.C.; Hauache,O.M.; Vieira,J.G.H.; Lazaretti-Castro,M.
Osteoporosis is a multifactorial disease with great impact on morbidity and mortality mainly in postmenopausal women. Although it is recognized that factors related to life-style and habits may influence bone mass formation leading to greater or lower bone mass, more than 85% of the variation in bone mineral density (BMD) is genetically determined. The collagen type I alpha 1 (COLIA1) gene is a possible risk factor for osteoporosis. We studied a population of 220 young women from the city of São Paulo, Brazil, with respect to BMD and its correlation with both COLIA1 genotype and clinical aspects. The distribution of COLIA1 genotype SS, Ss and ss in the population studied was 73.6, 24.1 and 2.3%, respectively. No association between these genotypes and...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: COLIA1; Bone mineral density; Risk factors; Polymorphism; Osteoporosis.
Ano: 2002
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002000800005

Vitamin D receptor alleles and bone mineral density in a normal premenopausal Brazilian female population
Provedor de dados: Brazilian Journal of Medical and Biological Research
Autores: Lazaretti-Castro,M.; Duarte-de-Oliveira,M.A.; Russo,E.M.K.; Vieira,J.G.H.
Studies on the association between vitamin D receptor (VDR) polymorphism and bone mineral density (BMD) in different populations have produced conflicting results probably due to ethnic differences in the populations studied. The Brazilian population is characterized by a very broad genetic background and a high degree of miscegenation. Of an initial group of 164, we studied 127 women from the city of São Paulo, aged 20 to 47 years (median, 31 years), with normal menses, a normal diet and no history of diseases or use of any medication that could alter BMD. VDR genotype was assessed by PCR amplification followed by BsmI digestion of DNA isolated from peripheral leukocytes. BMD was measured using dual energy X-ray absorptiometry (Lunar DPX) at the lumbar...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Vitamin D receptor genotype; Bone mineral density; Brazilian population.
Ano: 1997
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1997000800003

Circulating forms of parathyroid hormone detected with an immunofluorometric assay in patients with primary hyperparathyroidism and in hyperparathyroidism secondary to chronic renal failure
Provedor de dados: Brazilian Journal of Medical and Biological Research
Autores: Kunii,I.S.; Vieira,J.G.H.
In patients with uremia, intact parathyroid hormone (PTH) measurement appears to overestimate the biologically active hormone in circulation. The recent description of the accumulation in these patients of a non-intact PTH form measured by the standard immunometric assays, re-opened the question. In this study we submitted serum samples from 7 patients with primary hyperparathyroidism (PHP) and from 10 patients with hyperparathyroidism secondary to chronic renal failure (SHP) to preparative HPLC in order to discriminate the molecular forms measured by our currently used immunofluorometric assay for intact PTH. The elution profile obtained with the HPLC system showed two clearly defined peaks, the first one corresponding to a lower molecular weight form,...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Parathyroid hormone; Parathyroid hormone fragment; Immunometric assay; Primary hyperparathyroidism; Hyperparathyroidism secondary to chronic renal failure.
Ano: 2001
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001001200006

Fractures of the proximal femur: correlation with vitamin D receptor gene polymorphism
Provedor de dados: Brazilian Journal of Medical and Biological Research
Autores: Ramalho,A.C.; Lazaretti-Castro,M.; Hauache,O.; Kasamatsu,T.; Brandão,C.; Reis,A.F.; Takata,E.; Cafalli,F.; Tavares,F.; Gimeno,S.G.A.; Vieira,J.G.H.
Fractures are the feared consequences of osteoporosis and fractures of the proximal femur (FPF) are those that involve the highest morbidity and mortality. Thus far, evaluation of bone mineral density (BMD) is the best way to determine the risk of fracture. Genetic inheritance, in turn, is one of the major determinants of BMD. A correlation between different genotypes of the vitamin D receptor (VDR) and BMD has been recently reported. On this basis, we decided to determine the importance of the determination of VDR genotype in the presence of an osteoporotic FPF in a Brazilian population. We studied three groups: group I consisted of 73 elderly subjects older than 65 years (78.5 ± 7.2 years) hospitalized for nonpathological FPF; group II consisted of 50...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Osteoporosis; Fracture of proximal femur (FPF); Vitamin D receptor polymorphism.
Ano: 1998
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000700006

Specific insulin and proinsulin secretion in glucokinase-deficient individuals
Provedor de dados: Brazilian Journal of Medical and Biological Research
Autores: Pardini,V.C.; Velho,G.; Reis,R.; Purisch,S.; Blanché,H.; Vieira,J.G.H.; Moisés,R.C.S.
Glucokinase (GCK) is an enzyme that regulates insulin secretion, keeping glucose levels within a narrow range. Mutations in the glucokinase gene cause a rare form of diabetes called maturity-onset diabetes of the young (MODY). An early onset (less than 25 years), autosomal dominant inheritance and low insulin secretion stimulated by glucose characterize MODY patients. Specific insulin and proinsulin were measured in serum by immunofluorimetric assays (IFMA) during a 75-g oral glucose tolerance test (OGTT). Two kindreds (SA and LZ) were studied and compared to non-diabetic unrelated individuals (control group 1) matched for age and body mass index (BMI). In one kindred, some of these subjects were also obese (BMI &amp;gt;26 kg/m2), and other family members...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Proinsulin; Insulin; MODY; Glucokinase; Obesity.
Ano: 1999
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000400008