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The effect of microgravity on tissue structure and function of rat testis
Provedor de dados: 56
Autores: Ding,Ye; Tang,Jin; Zou,Jun; She,Ruiping; Wang,Yinghua; Yue,Zhuo; Tian,Jijing; Xia,Kangkang; Yin,Jun; Wang,Desheng.
To explore whether an environment of weightlessness will cause damage to the reproductive system of animals, we used the tail-suspension model to simulate microgravity, and investigated the effect of microgravity on the tissue structure and function of the testis in sexually mature male rats. Forty-eight male Wistar rats weighing 200-250 g were randomly assigned to three groups (N = 16 each): control, tail traction, and tail suspension. After the rats were suspended for 7 or 14 days, morphological changes of testis were evaluated by histological and electron microscopic methods. The expression of HSP70, bax/bcl-2 and AR (androgen receptor) in testis was measured by immunohistochemistry. Obvious pathological lesions were present in the testis after the rats...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Simulated microgravity; Histopathology; AR; HSP70; Bax/bcl-2; Testis.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011001200007