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A meta-analysis of metronidazole and vancomycin for the treatment of Clostridium difﬁcile infection, stratiﬁed by disease severity
Provedor de dados: Brazilian Journal of Infectious Diseases
Autores: Di,Xiuzhen; Bai,Nan; Zhang,Xin; Liu,Bin; Ni,Wentao; Wang,Jin; Wang,Kai; Liang,Beibei; Liu,Youning; Wang,Rui.
The aim of this meta-analysis was to compare the efﬁcacy of metronidazole and vancomycin for the treatment of Clostridium difﬁcileinfection, especially to investigate which agent was superior for treating either mild or severe C. difﬁcileinfection. A meta-analysis of randomized controlled trials and cohort studies identiﬁed in Pubmed, Embase, and the Cochrane Library was conducted. Four randomized controlled trials and two cohort studies involving 1218 patients were included in this meta-analysis. Metronidazole was inferior to vancomycin for treating C. difﬁcileinfection in terms of both initial clinical cure rates (risk ratio, RR = 0.91, 95% conﬁdence interval, CI = 0.84-0.98, p= 0.02) and sustained cure rates (RR = 0.88, 95% CI = 0.82-0.96, p= 0.003)....
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Clostridium difﬁcile; Clostridium difﬁcileinfection (CDI); Vancomycin; Metronidazole.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000400339