Consulta: creatorFacets:"Wang,Y."
Registros recuperados: 11
Data/hora: 13/06/2024 21:53:20

Seroprevalence of toxoplasma gondii infection in goats in the five northwestern provinces of China
Provedor de dados: 45
Autores: Wang,Y.; Qin,X.; Chen,Y.; Xing,J.; Gao,J.; Qiu,D.
RESUMO O objetivo do presente estudo foi investigar a soroprevalência de infecção com Toxoplasma gondii (T. gondii) em cabras em cinco províncias do noroeste da China. Soroprevalência foi determinado usando o kit de teste de ensaio de imunoabsorção enzimática (ELISA). A soroprevalência geral foi 21.23% (197/928). Análise estatística revlou que diferenças significativas foram observadas em fêmeas (P= 0.048, OR= 0.567, 95% CI= 0.309 a 1.041) e nos grupos ≥ 2 (P= 0.002, OR= 0.330, 95% CI= 0.224 a 0.488). Nenhuma diferença estatisticamente significativa foi observada entre diferentes províncias. Nossos resultados indicam que a infecção com T. gondii, que pode ter implicações importantes sobre a saúde pública, teve diferenças significativas em sexo e idade, mas...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Toxoplasma gondii; Seroprevalence; Goat; Five northwestern provinces.
Ano: 2020
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352020000100277

Investigating ego modules and pathways in osteosarcoma by integrating the EgoNet algorithm and pathway analysis
Provedor de dados: 56
Autores: Chen,X.Y.; Chen,Y.H.; Zhang,L.J.; Wang,Y.; Tong,Z.C.
Osteosarcoma (OS) is the most common primary bone malignancy, but current therapies are far from effective for all patients. A better understanding of the pathological mechanism of OS may help to achieve new treatments for this tumor. Hence, the objective of this study was to investigate ego modules and pathways in OS utilizing EgoNet algorithm and pathway-related analysis, and reveal pathological mechanisms underlying OS. The EgoNet algorithm comprises four steps: constructing background protein-protein interaction (PPI) network (PPIN) based on gene expression data and PPI data; extracting differential expression network (DEN) from the background PPIN; identifying ego genes according to topological features of genes in reweighted DEN; and collecting ego...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Osteosarcoma; Ego; Genes; Modules; Pathways.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2017000200607

Effect of salt intake and potassium supplementation on brachial-ankle pulse wave velocity in Chinese subjects: an interventional study
Provedor de dados: 56
Autores: Wang,Y.; Mu,J.J.; Geng,L.K.; Wang,D.; Ren,K.Y.; Guo,T.S.; Chu,C.; Xie,B.Q.; Liu,F.Q.; Yuan,Z.Y.
Accumulating evidence has suggested that high salt and potassium might be associated with vascular function. The aim of this study was to investigate the effect of salt intake and potassium supplementation on brachial-ankle pulse wave velocity (PWV) in Chinese subjects. Forty-nine subjects (28-65 years of age) were selected from a rural community of northern China. All subjects were sequentially maintained on a low-salt diet for 7 days (3.0 g/day NaCl), a high-salt diet for an additional 7 days (18.0 g/day NaCl), and a high-salt diet with potassium supplementation for a final 7 days (18.0 g/day NaCl+4.5 g/day KCl). Brachial-ankle PWV was measured at baseline and on the last day of each intervention. Blood pressure levels were significantly increased from...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Pulse wave velocity; Salt; Potassium; Interventional study.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2015000100083

The role of necroptosis in neurosurgical diseases
Provedor de dados: 56
Autores: Liu,T.; Bao,Y.H.; Wang,Y.; Jiang,J.Y.
Programmed necrosis or necroptosis is an alternative form of cell death that is executed through a caspase-independent pathway. Necroptosis has been implicated in many pathological conditions. Genetic or pharmacological inhibition of necroptotic signaling has been shown to confer neuroprotection after traumatic and ischemic brain injury. Therefore, the necroptotic pathway represents a potential target for neurological diseases that are managed by neurosurgeons. In this review, we summarize recent advances in the understanding of necroptotic signaling pathways and explore the role of necroptotic cell death in craniocerebral trauma, brain tumors, and cerebrovascular diseases.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Molecular mechanism; Pathogenesis; Programmed cell death; Therapy.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2015000400292

Therapy of tacrolimus combined with corticosteroids in idiopathic membranous nephropathy
Provedor de dados: 56
Autores: Cui,W.; Lu,X.; Min,X.; Liu,M.; Guan,S.; Wang,Y.; Luo,M.; Li,W.; Li,Q.; Dong,W.; Miao,L.; Luo,P.
We evaluated the efficacy and safety of tacrolimus (TAC) combined with corticosteroids in treating patients with idiopathic membranous nephropathy (IMN). One hundred seventy-seven biopsy-proven IMN patients were recruited in this retrospective clinical study. Sixty patients received TAC (target blood concentration of 4–8 ng/mL) and 117 patients received daily cyclophosphamide (CYC, 100 mg) combined with prednisone. Remission rates at the end of the first, second and third month in the TAC group were significantly higher than that in the CYC group (1st: 35.0 vs 19.7%, P&lt;0.05; 2nd: 56.7 vs 38.5%, P&lt;0.05; 3rd: 76.7 vs 59.0%, P&lt;0.05). In the first 3 months, daily urinary protein and serum albumin in the TAC group obtained a better improvement than...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Cyclophosphamide; Efficacy; Idiopathic membranous nephropathy; Retrospective clinical study; Tacrolimus.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2017000400703

Rankl expression predicts poor prognosis in gastric cancer patients: results from a retrospective and single-center analysis
Provedor de dados: 56
Autores: Zhang,X.; Song,Y.; Song,N.; Zhang,L.; Wang,Y.; Li,D.; Wang,Z.; Qu,X.; Liu,Y.
The receptor activator of nuclear factor κB ligand (RANKL)/RANK pathway plays an important role in the prognosis of several solid tumor types, but its role in gastric cancer prognosis has been poorly characterized. A total of 116 gastric cancer patients who underwent surgical resection were enrolled in this study. Expressions of RANKL and RANK in gastric cancer tissues were detected using immunohistochemical staining. Thirty-eight patients (33%) showed a high level of RANKL expression and 61 patients (53%) showed a high level of RANK expression. There was a positive correlation between expressions of RANKL and RANK (P=0.014, r=0.221). A high level of RANKL expression indicated shorter overall survival (OS) (P=0.008), and was associated with a higher...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: RANKL; RANK; Gastric cancer; IHC; Overall survival.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018000300602

Characterization of air-liquid interface culture of A549 alveolar epithelial cells
Provedor de dados: 56
Autores: Wu,J.; Wang,Y.; Liu,G.; Jia,Y.; Yang,J.; Shi,J.; Dong,J.; Wei,J.; Liu,X.
Alveolar epithelia play an essential role in maintaining the integrity and homeostasis of lungs, in which alveolar epithelial type II cells (AECII) are a cell type with stem cell potential for epithelial injury repair and regeneration. However, mechanisms behind the physiological and pathological roles of alveolar epithelia in human lungs remain largely unknown, partially owing to the difficulty of isolation and culture of primary human AECII cells. In the present study, we aimed to characterize alveolar epithelia generated from A549 lung adenocarcinoma cells that were cultured in an air-liquid interface (ALI) state. Morphological analysis demonstrated that A549 cells could reconstitute epithelial layers in ALI cultures as evaluated by histochemistry...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Alveolar epithelium; A549 cells; Air-liquid interface; Alveolar epithelial type II cells; Alveolar epithelial type I cells.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018000200609

Down-regulation of single-stranded DNA-binding protein 1 expression induced by HCMV infection promotes lipid accumulation in cells
Provedor de dados: 56
Autores: Guo,N.; Zhang,N.; Yan,L.; Cao,X.; Lv,F.; Wang,J.; Wang,Y.; Cong,H.
The objective of this study was to observe the infection of human cytomegalovirus (HCMV) to human umbilical vein endothelial cells, and its effect on the expression of single-stranded DNA-binding protein (SSBP1) and on lipid metabolism in endothelial cells. We screened the differential expression of mRNAs after HCMV infection by suppression subtractive hybridization and the expression levels of SSBP1 mRNA and protein after HCMV infection by real-time PCR and western blot. After verification of successful infection by indirect immunofluorescent staining and RT-PCR, we found a differential expression of lipid metabolism-related genes including LDLR, SCARB, CETP, HMGCR, ApoB and LPL induced by HCMV infection. The expression levels of SSBP1 mRNA and protein...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HCMV; SSBP1; HUVEC; Lipid accumulation; LDLR.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2017001100605

Prognosis of colorectal cancer with liver metastasis: value of a prognostic index
Provedor de dados: 56
Autores: Wang,Y.; Liu,Y.F.; Cheng,Y.; Yi,D.H.; Li,P.; Song,W.Q.; Fu,D.Z.; Wang,X.
The objective of the present study was to explore the factors related to the prognosis of colorectal cancer (CRC) and to establish a prognostic model for the selection of patients who might benefit from hepatic resection for metastatic CRC. A total of 293 patients undergoing liver resection for metastatic CRC (172 males and 80 females ranging in age from 26 to 80 years) were selected and clinical, pathological and outcome data were examined in this retrospective study. The prognostic index (PI) of the patients was calculated on the basis of results of multivariate analysis. Patients were stratified into different groups, with survival curves projected according to PI. The 1-, 3-, and 5-year overall survival rates were 58.3, 26.4, and 11.3%, respectively....
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Colorectal cancer; Liver metastasis; Prognosis.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010001100015

Salt-induced epithelial-to-mesenchymal transition in Dahl salt-sensitive rats is dependent on elevated blood pressure
Provedor de dados: 56
Autores: Wang,Y.; Mu,J.J.; Liu,F.Q.; Ren,K.Y.; Xiao,H.Y.; Yang,Z.; Yuan,Z.Y.
Dietary salt intake has been linked to hypertension and cardiovascular disease. Accumulating evidence has indicated that salt-sensitive individuals on high salt intake are more likely to develop renal fibrosis. Epithelial-to-mesenchymal transition (EMT) participates in the development and progression of renal fibrosis in humans and animals. The objective of this study was to investigate the impact of a high-salt diet on EMT in Dahl salt-sensitive (SS) rats. Twenty-four male SS and consomic SS-13BN rats were randomized to a normal diet or a high-salt diet. After 4 weeks, systolic blood pressure (SBP) and albuminuria were analyzed, and renal fibrosis was histopathologically evaluated. Tubular EMT was evaluated using immunohistochemistry and real-time PCR...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Dahl salt-sensitive rats; High salt intake; EMT; Renal fibrosis.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2014000300223

Quercetin postconditioning attenuates myocardial ischemia/reperfusion injury in rats through the PI3K/Akt pathway
Provedor de dados: 56
Autores: Wang,Y.; Zhang,Z.Z.; Wu,Y.; Ke,J.J.; He,X.H.; Wang,Y.L.
Quercetin (Que), a plant-derived flavonoid, has multiple benefical actions on the cardiovascular system. The current study investigated whether Que postconditioning has any protective effects on myocardial ischemia/reperfusion (I/R) injury in vivo and its potential cardioprotective mechanisms. Male Sprague-Dawley rats were randomly allocated to 5 groups (20 animals/group): sham, I/R, Que postconditioning, Que+LY294002 [a phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway inhibitor], and LY294002+I/R. I/R was produced by 30-min coronary occlusion followed by 2-h reperfusion. At the end of reperfusion, myocardial infarct size and biochemical changes were compared. Apoptosis was evaluated by both TUNEL staining and measurement of activated caspase-3...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Ischemia and reperfusion; Quercetin; Postconditioning; PI3K/Akt.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2013001000861