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Polymorphism of human haptoglobin and its clinical importance
Provedor de dados: Genetics and Molecular Biology
Autores: Wobeto,Vânia Peretti de Albuquerque; Zaccariotto,Tânia Regina; Sonati,Maria de Fátima.
Haptoglobin (Hp) is a plasma glycoprotein, the main biological function of which is to bind free hemoglobin (Hb) and prevent the loss of iron and subsequent kidney damage following intravascular hemolysis. Haptoglobin is also a positive acute-phase protein with immunomodulatory properties. In humans, the HP locus is polymorphic, with two codominant alleles (HP1 and HP2) that yield three distinct genotypes/phenotypes (Hp1-1, Hp2-1 and Hp2-2). The corresponding proteins have structural and functional differences that may influence the susceptibility and/or outcome in several diseases. This article summarizes the available data on the structure and functions of Hp and the possible effects of Hp polymorphism in a number of important human disorders.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Haptoglobin; Hemoglobin; Genetic polymorphisms.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572008000400002