Consulta: creatorFacets:"Wong,D.V.T."
Registros recuperados: 1
Data/hora: 11/06/2024 02:10:20

Amifostine reduces inflammation and protects against 5-fluorouracil-induced oral mucositis and hyposalivation
Provedor de dados: 56
Autores: Barbosa,S.C.M.; Pereira,V.B.M.; Wong,D.V.T.; Santana,A.P.M.; Lucetti,L.T.; Carvalho,L.L.; Barbosa,C.R.N.; Callado,R.B.; Silva,C.A.A.; Lopes,C.D.H.; Brito,G.A.C.; Alencar,N.M.N.; Lima-Júnior,R.C.P.
Oral mucositis (OM) is a common and dose-limiting side effect of cancer treatment, including 5-fluorouracil (5-FU) and radiotherapy. The efficacy of the therapeutic measures to prevent OM is limited and disease prevention is not fully observable. Amifostine is a cytoprotective agent with a described anti-inflammatory potential. It is clinically used to reduce radiotherapy and chemotherapy-associated xerostomia. This study investigated the protective effect of amifostine on an experimental model of OM. Hamsters were divided into six groups: saline control group (5 mL/kg), mechanical trauma (scratches) of the right cheek pouch; 5-FU (60 and 40 mg/kg, ip, respectively, administered on days 1 and 2); amifostine (12.5, 25, or 50 mg/kg) + 5-FU + scratches....
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Cancer chemotherapy toxicity; Oral mucositis; 5-Fluorouracil; Amifostine; Cytokines.
Ano: 2019
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2019000300601