Consulta: creatorFacets:"Zheng,J.H."
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Data/hora: 02/06/2024 09:15:55

Early responses of the STAT3 pathway to platinum drugs are associated with cisplatin resistance in epithelial ovarian cancer
Provedor de dados: 56
Autores: Sheng,W.J.; Jiang,H.; Wu,D.L.; Zheng,J.H.
Cisplatin resistance remains one of the major obstacles when treating epithelial ovarian cancer. Because oxaliplatin and nedaplatin are effective against cisplatin-resistant ovarian cancer in clinical trials and signal transducer and activator of transcription 3 (STAT3) is associated with cisplatin resistance, we investigated whether overcoming cisplatin resistance by oxaliplatin and nedaplatin was associated with the STAT3 pathway in ovarian cancer. Alamar blue, clonogenic, and wound healing assays, and Western blot analysis were used to compare the effects of platinum drugs in SKOV-3 cells. At an equitoxic dose, oxaliplatin and nedaplatin exhibited similar inhibitory effects on colony-forming ability and greater inhibition on cell motility than cisplatin...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Epithelial ovarian cancer; Cisplatin; Oxaliplatin; Nedaplatin; STAT3.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2013000800650