Consulta: creatorFacets:"da-Silva,Â.C.F."
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Antinociceptive and anti-inflammatory activities of a triterpene-rich fraction from Himatanthus drasticus
Provedor de dados: Brazilian Journal of Medical and Biological Research
Autores: de-Almeida,S.C.X.; da-Silva,Â.C.F.; Sousa,N.R.T.; Amorim,I.H.F.; Leite,B.G.; Neves,K.R.T.; Costa,J.G.M.; Felipe,C.F.B.; de-Barros Viana,G.S.
Himatanthus drasticus (Mart.) Plumel belongs to the Apocynaceae family and the latex from its trunk bark (Hd) is known as “janaguba milk”. This latex is widely used in Northeast Brazil, mainly in the Cariri region, for its gastroprotective, anti-inflammatory, and antitumor properties. The objective of this study was to investigate a triterpene-rich fraction (FJNB) from H. drasticus latex on acute models of nociception and inflammation and to clarify its mechanisms of action. Wistar rats or Swiss mice were subjected to the carrageenan-induced paw edema test or the formalin test, respectively, after the acute oral treatment with FJNB. The inflamed paws from the carrageenan-induced paw edema and formalin tests were processed for histological and...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Pentacyclic triterpenes; Lupeol; Alpha-amyrin; Beta-amyrin; Inflammation; Himatanthus drasticus.
Ano: 2019
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2019000500612