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Angiotensin II type 1 receptor A1166C GENE polymorphism and essential hypertension in San Luis
Provedor de dados: 47
Autores: Lapierre,Alicia Viviana; Arce,María Elena; Lopez,José Raúl; Ciuffo,Gladys María.
Essential hypertension is considered a multifactorial trait resulting from a combination of environmental and genetic factors. The angiotensin II type 1 receptor mediates the vasoconstrictor and growthpromoting effects of Ang II. The A1166C polymorphism of the AT1 receptor gene may be associated with cardiovascular phenotypes, such as high arterial blood pressure, aortic stiffness, and increased cardiovascular risk. We investigated the association between this A1166C polymorphism and hypertension in hypertense and normotense subjects from San Luis (Argentina) by mismatch PCR-RFLP analysis. Hypertense patients exhibited significant increases in lipid related values and body mass index. The frequency of occurrence of the C1166 allele was higher among...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Angiotensin II; A1166C polymorphism; Risk factors; RAS system; Pharmacogenetics.
Ano: 2006
URL: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0327-95452006000300005