Consulta: subjectFacets:"Adaptive immunity"
Registros recuperados: 2
Data/hora: 09/06/2024 15:56:03

Immune System Dysfunction in the Elderly
Provedor de dados: 42
Autores: FUENTES,EDUARDO; FUENTES,MANUEL; ALARCÓN,MARCELO; PALOMO,IVÁN.
ABSTRACT Human aging is characterized by both physical and physiological frailty that profoundly affects the immune system. In this context aging is associated with declines in adaptive and innate immunity established as immunosenescence. Immunosenescence is a new concept that reflects the age-associated restructuring changes of innate and adaptive immune functions. Thus elderly individuals usually present chronic low-level inflammation, higher infection rates and chronic diseases. A study of alterations in the immune system during aging could provide a potentially useful biomarker for the evaluation of immune senescence treatment. The immune system is the result of the interplay between innate and adaptive immunity, yet the impact of aging on this...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Aging; Immunosenescence; Adaptive immunity; Innate immunity; Inflammation.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652017000100285

Linking immunity and hematopoiesis by bone marrow T cell activity
Provedor de dados: 56
Autores: Monteiro,J.P.; Bonomo,A.
Two different levels of control for bone marrow hematopoiesis are believed to exist. On the one hand, normal blood cell distribution is believed to be maintained in healthy subjects by an "innate" hematopoietic activity, i.e., a basal intrinsic bone marrow activity. On the other hand, an "adaptive" hematopoietic state develops in response to stress-induced stimulation. This adaptive hematopoiesis targets specific lineage amplification depending on the nature of the stimuli. Unexpectedly, recent data have shown that what we call "normal hematopoiesis" is a stress-induced state maintained by activated bone marrow CD4+ T cells. This T cell population includes a large number of recently stimulated cells in normal mice whose priming requires the presence of the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: T cell; Hematopoiesis; Innate immunity; Adaptive immunity; Bone marrow; Immunological memory.
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005001000004