Consulta: subjectFacets:"Adjuvant arthritis"
Registros recuperados: 3
Data/hora: 10/06/2024 01:21:41

Administration of interferon-g to pregnant rats reverses the depressed adjuvant-induced arthritis of their chronically Trypanosoma cruzi-infected offspring
Provedor de dados: Brazilian Journal of Medical and Biological Research
Autores: Didoli,G.; Revelli,S.; Davila,H.; Ferro,M.E.; Romero-Piffiguer,M.; Bottasso,O.
We demonstrated that administration of interferon gamma (IFN-&lt;FONT FACE="Symbol"&gt;g&lt;/font&gt;) to the inbred "l" strain of pregnant rats conferred partial resistance on their offspring to challenge with Trypanosoma cruzi. We now examine if this intervention also modifies the reportedly immunodepressed cellular responses which occur during chronic infection. Offspring were born to mothers undergoing one of the following procedures during gestation: subcutaneous injections of recombinant rat IFN-&lt;FONT FACE="Symbol"&gt;g&lt;/font&gt;, 50,000 IU/rat, five times/week for 3 weeks, which was started on the day of mating (IFN-Mo); infection with 106 trypomastigotes of T. cruzi at 7, 14, and 21 days after mating plus IFN-&lt;FONT...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Interferon gamma; Adjuvant arthritis; T. cruzi; T cell subsets.
Ano: 1999
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000600011

Cyclosporin inhibits hyperalgesia and edema in arthritic rats: role of the central nervous system
Provedor de dados: Brazilian Journal of Medical and Biological Research
Since arthritis induced by Mycobacterium products (adjuvant) in rats is considered to be immunologically driven, the objective of the present study was to determine if the immunosuppressor drug cyclosporin could affect hindpaw edema and joint hyperalgesia simultaneously. Female Holtzman rats (140-170 g) presented hyperalgesia and edema on the 8th and 12th day following adjuvant injection. Daily systemic (oral or intramuscular) administration of cyclosporin (0.5-5.0 mg kg-1 day-1) or dexamethasone (0.01-0.1 mg kg-1 day-1) for 15 days starting on day zero dose-dependently inhibited the hindpaw edema and hyperalgesia in arthritic rats. However, hyperalgesia but not edema could be detected two days after cyclosporin withdrawal. We concluded that a) the...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Cyclosporin; Hyperalgesia; Edema; Adjuvant arthritis.
Ano: 1997
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1997000100016

Role of endogenous glucocorticoids in hyperalgesia and edema in old arthritic rats
Provedor de dados: Brazilian Journal of Medical and Biological Research
Autores: Yokoro,C.M.; Tatsuo,M.A.K.F.; Pereira,L.S.M.; Alves,D.L.F.; Francischi,J.N.
We compared the intensity and frequency of arthritis in old (8-12 months, N = 12) and juvenile (2 months, N = 10) rats and determined the role played by adrenal glands in this disorder. Arthritis was induced by subcutaneous injection of Mycobacterium butyricum at the base of the tail of female Holtzman rats at day zero. Paw edema and hyperalgesia were monitored from day zero to day 21 after induction as signs of arthritis development. Some (N = 11) old animals were adrenalectomized bilaterally and treated with dexamethasone or celecoxib immediately following surgery. All bilaterally adrenalectomized old animals became susceptible to arthritis and the onset of disease was shortened from the 10th to the 5th day. Hyperalgesia and paw edema responses were less...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Hyperalgesia; Edema; Adjuvant arthritis; Adrenalectomy; Dexamethasone; Old rats.
Ano: 2003
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003000100011