Consulta: subjectFacets:"Allele-specific copy number"
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Data/hora: 03/06/2024 18:42:28

Analysis of gene expression changes associated with human carcinoma-associated fibroblasts in non-small cell lung carcinoma
Provedor de dados: 48
Autores: Wu,Xiaofen; Ruan,Lei; Yang,Yi; Mei,Qi.
Abstract  Background  This study aimed to investigate the gene expression changes associated with carcinoma-associated fibroblasts (CAFs) involving in non-small cell lung carcinoma (NSCLC).  Methods  We downloaded the GEO series GSE22862, which contained matched gene expression values for 15 CAF and normal fibroblasts samples, and series GSE27289 containing SNP genotyping for four matched NSCLC samples. The differentially expressed genes in CAF samples were identified using the limma package in R. Then we performed gene ontology (GO) and pathway enrichment analysis and protein&amp;#8211;protein interaction (PPI) network construction using the identified DEGs. Moreover, aberrant cell fraction, ploidy, allele-specific copy number, and loss of heterozygosity...
Tipo: Journal article
Palavras-chave: Carcinoma-associated fibroblast; Non-small cell lung carcinoma; Differentially expressed genes; Allele-specific copy number; Functional analysis.
Ano: 2017
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602017000100204