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Alterins Produced by Oyster-Associated Pseudoalteromonas are Antibacterial Cyclolipopeptides with LPS-Binding Activity
Provedor de dados: 5
Autores: Desriac, Florie; El Harras, Abderrafek; Simon, Matthieu; Bondon, Arnaud; Brillet, Benjamin; Le Chevalier, Patrick; Pugnière, Martine; Got, Patrice; Destoumieux-garzón, Delphine; Fleury, Yannick.
Discovery after discovery, host-associated microbiota reveal a growing list of positive effects on host homeostasis by contributing to host nutrition, improving hosts’ immune systems and protecting hosts against pathogens. In that context, a collection of oyster associated bacteria producing antibacterial compounds have been established to evaluate their role in non-host-derived immunity. Here, we described alterins; potent anti-Gram negative compounds produced by Pseudoalteromonas hCg-6 and hCg-42 isolated from different healthy oyster hemolymph. The strains hCg-6 and hCg-42 produce a set of at least seven antibacterial compounds, ranging from 926 to 982 Da structurally characterized as cyclolipopeptides (CLPs). Alterins share the same cationic...
Tipo: Text
Palavras-chave: Pseudoalteromonas; Cyclolipopeptides; Alterin; Antibiotic.
Ano: 2020
URL: https://archimer.ifremer.fr/doc/00663/77511/79275.pdf