Consulta: subjectFacets:"Analgesic"
Registros recuperados: 13
Data/hora: 03/06/2024 07:33:41

Preclinical validation of antinociceptive, antiinflammatory, and antipyretic activities of Cordia martinicensis leave decoction
Provedor de dados: Revista Cubana de Plantas Medicinales
Autores: Martínez Hormaza,Ioanna; Victoria Amador,María del Carmen; Brito Álvarez,Gisselle; Morón Rodríguez,Francisco; López Barreiro,Marisol; García Hernández,Ana Ibis; Duménigo González,Abel; Morejón Rodríguez,Zulema; Bacallao Elguea,Yunier; Nossin,Emmanuel.
Introduction: leave decoction of Cordia martinicensis (Jacq.) Roem. &amp;amp; Schult. is commonly used in Dominica, Martinique and St. Lucia to relieve thoracic pain and fever. Objectives: to validate the antiinflammatory, antinociceptive (analgesic), and antipyretic ethnobotanical uses of Cordia martinicensis in experimental animal models. Methods: 30 % aqueous extract of Cordia martinicensis dry leaves was prepared just before use. Analgesic activity was assayed by writhing and tail flick, and antiinflammatory activity by the ear oedema test, both in mice. Finally, antipyretic activity was tested by inducing pyrexia with brewer's yeast in rats. Results: decoction of Cordia martinicensis significantly decreased the number of abdominal stretchings by 44.4...
Tipo: Journal article
Palavras-chave: Cordia martinicensis; Analgesic; Antiinflammatory; Antipyretic.
Ano: 2014
URL: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1028-47962014000100005

Analgesic and anti-arthritic effect of Corallocarpus epigaeus
Provedor de dados: Acta Bioquímica Clínica Latinoamericana
Autores: Uthrapathy,Subashini; Shabi,Mohamed M; Krishnamoorthy,Gayathri; Ravindhran,Dhevi; Rajamanickam,Victor G; Pillay Dubey,Govindha.
Rheumatoid arthritis is a chronic inflammatory joint disease associated with the development of oxidative stress and inflammation. The safety and efficacy profile of 85% methanolic extract of Corallocarpus epigaeus (CE) was evaluated in the present study. In safety profile LD50 value was determined by carrying out an acute toxicity study. In efficacy profile, the analgesic activity was evaluated by both hot plate and tail immersion tests. The anti-inflammatory activity was assessed by carrageenan-induced paw edema and anti-arthritic effect by complete Freund's adjuvant induced arthritis. Phytochemical screening of different CE extracts and quantitative analysis of both raw herb and 85% methanolic extract have been also carried out. The methanolic extract...
Palavras-chave: Corallocarpus epigaeus; Analgesic; Anti-inflammatory and antioxidant properties; Hot plate; Tail immersion; Carrageenan; Complete Freund's adjuvant.
Ano: 2011
URL: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0325-29572011000400006

Bioactivities of the ethanol extract from Ageratum fastigiatum branches: antioxidant, antinociceptive and anti-inflammatory
Provedor de dados: Anais da Academia Brasileira de Ciências
Autores: DEL-VECHIO-VIEIRA,GLAUCIEMAR; SANTOS,BRUNA C.S.; ALVES,MARIA SILVANA; ARAÚJO,AÍLSON L.A.; YAMAMOTO,CÉLIA H.; PINTO,MÍRIAM A.O.; KAPLAN,MARIA AUXILIADORA C.; SOUSA,ORLANDO V.
ABSTRACT The present study was designed to investigate the antioxidant, antinociceptive and anti-inflammatory activities of the ethanol extract from Ageratum fastigiatum branches. Phytochemical screening and total phenol and flavonoid contents were determined. The antioxidant activity was assessed by 2,2-diphenyl-1-pycrilhydrazin (DPPH) and iron reducing power methods. The antinociceptive effect was evaluated using the acetic acid-induced writhing, formalin, hot plate and tail immersion assays; while the carrageenan-induced paw edema and pleurisy tests were performed to examine the anti-inflammatory activity against acute inflammation. The extract revealed the presence of flavonoids, tannins, coumarins, terpenes, sterols and saponins. Expressive levels of...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Ageratum fastigiatum; Analgesic; Anti-inflammatory; Antioxidant; Flavonoids; Total phenols.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652016000401471

Investigation of local anesthetic and antimycobacterial activity of Ottonia martiana Miq. (Piperaceae)
Provedor de dados: Anais da Academia Brasileira de Ciências
Autores: CUNICO,MIRIAM M.; TREBIEN,HERBERT A.; GALETTI,FÁBIO C.; MIGUEL,OBDULIO G.; MIGUEL,MARILIS D.; AUER,CELSO G.; SILVA,CÉLIO L.; SOUZA,ANA OLÍVIA DE.
ABSTRACT Ottonia martiana is a plant popularly known in Brazil by the use for toothache. Ethanolic extract (EE), hexane fraction (HF), dichloromethane fraction (DF) and piperovatine obtained from O. martiana were assayed in vitro and in vivo. The acute toxicity of EE was determined, and LD50 values of 164.5 and 65.0 mg/kg by the oral and intraperitoneal routes, respectively, indicated a high toxicity for EE in vivo, explaining its popular use by topical administration only. A local anesthetic-like effect of EE and its fractions was observed in experimental models using pain induction, and such effect involved an analgesic action. The antimycobacterial activity of EE, HF, DF and piperovatine was evaluated against Mycobacterium tuberculosis H37Rv ATCC 27924....
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Analgesic; Anesthetic; Antimycobacterial; Ottonia martiana; Piperaceae; Piperovatine.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652015000501991

In vivo analgesic, antipyretic, and anti-inflammatory potential in Swiss albino mice and in vitro thrombolytic activity of hydroalcoholic extract from Litsea glutinosaleaves
Provedor de dados: Biological Research
Autores: Bhowmick,Rumpa; Sarwa,Md Shahid; Dewan,Syed Masudur Rahman; Das,Abhijit; Das,Binayok; Uddin,Mir Muhammad Nasir; Islam,Md Siddiqul; Islam,Mohammad Safiqul.
BACKGROUND: The study was conducted to evaluate the in vitro thrombolytic activity, and in vivo analgesic, anti-inflammatory and antipyretic potentials of different hydrocarbon soluble extracts of Litsea glutinosaleaves for the first time widely used in the folkloric treatments in Bangladesh. This work aimed to create new insights on the fundamental mechanisms of the plant extracts involved in these activities. RESULTS: In thrombolytic activity assay, a significant clot disruption was observed at dose of 1 mg/mL for each of the extracts (volume 100 &amp;#956;L) when compared to the standard drug streptokinase. The n-hexane, ethyl acetate, chloroform, and crude methanolic extracts showed 32.23&amp;#8201;±&amp;#8201;0.26, 37.67&amp;#8201;±&amp;#8201;1.31,...
Tipo: Journal article
Palavras-chave: Acetic acid induced writhing; Analgesic; Anti-inflammatory; Antipyretic; Litsea glutinosa; Thrombolytic.
Ano: 2014
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602014000100050

Assessment of pharmacological activities of two medicinal plant of Bangladesh: Launaea sarmentosa and Aegialitis rotundifolia roxb in the management of pain, pyrexia and inflammation
Provedor de dados: Biological Research
Autores: Raju,Golam Sarwar; Moghal,Md Mizanur Rahman; Hossain,Mohammad Salim; Hassan,Md Mahadi; Billah,Md Mustahsan; Ahamed,Sayed Koushik; Rana,SM Masud.
BACKGROUND: The current study aims at evaluating the analgesic, anti-pyretic and anti-inflammatory properties of methanolic extract of the stem, bark and leaves of Launaea sarmentosa and Aegialitis rotundifolia roxb. RESULTS: The AELS and AEAR extract presented a significant (***p &lt; 0.001) dose dependent increase in reaction time in writhing method and showed inhibition of 63.1% and 57.1% respectively at the doses of 400 mg/kg body weight while standard drug showed (P &lt; 0.001) inhibition of 69.23%. In tail immersion method, AELS and AEAR showed maximum time of tail retention at 30 min in hot water i.e. 6.93 sec and 6.54 sec respectively at highest doses of 400 mg/kg body weight than lower dose while standard pentazocine showed reaction time of 7.62...
Tipo: Journal article
Palavras-chave: Launaea sarmentosa; Aegialitis rotundifolia roxb; Analgesic; Antipyretic; Anti-inflammatory.
Ano: 2014
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602014000100049

Antinociceptive effects of the essential oil of Croton nepetaefolius on mice
Provedor de dados: Brazilian Journal of Medical and Biological Research
Autores: Abdon,A.P.V.; Leal-Cardoso,J.H.; Coelho-de-Souza,A.N.; Morais,S.M.; Santos,C.F.
Croton nepetaefolius Baill., is an aromatic plant native to the northeast of Brazil where it is extensively used in folk medicine as a sedative, orexigen and antispasmodic agent. In the present study the antinociceptive effects of the essential oil of C. nepetaefolius (EOCn), administered orally, were evaluated in male Swiss mice (20-25 g). In the acetic acid-induced writhing test, EOCn (100 and 300 mg/kg; N = 14 and N = 12, respectively) was effective at the highest dose. In the hot-plate test, EOCn at 30 and 300 mg/kg, but not at 3 mg/kg, significantly increased the latency at all observation times up to the 180th min (N = 12 for each dose). In the formalin test, EOCn significantly reduced paw licking in the second phase of the test at 100 mg/kg (N =...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Croton nepetaefolius; Essential oil; Analgesic; Antinociception; Formalin test; Hot-plate test.
Ano: 2002
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002001000015

Anti-inflammatory and antinociceptive activities of an acid fraction of the seeds of Carpotroche brasiliensis (Raddi) (Flacourtiaceae)
Provedor de dados: Brazilian Journal of Medical and Biological Research
Autores: Lima,J.A.; Oliveira,A.S.; Miranda,A.L.P. de; Rezende,C.M.; Pinto,A.C.
Carpotroche brasiliensis is a native Brazilian tree belonging to the Oncobeae tribe of Flacourtiaceae. The oil extracted from its seeds contains as major constituents the same cyclopentenyl fatty acids hydnocarpic (40.5%), chaulmoogric (14.0%) and gorlic (16.1%) acids found in the better known chaulmoogra oil prepared from the seeds of various species of Hydnocarpus (Flacourtiaceae). These acids are known to be related to the pharmacological activities of these plants and to their use as anti-leprotic agents. Although C. brasiliensis oil has been used in the treatment of leprosy, a disease that elicits inflammatory responses, the anti-inflammatory and analgesic activities of the oil and its constituents have never been characterized. We describe the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Carpotroche brasiliensis; Flacourtiaceae; Cyclopentenyl fatty acids; Anti-inflammatory effec; Analgesic; Antinociceptive effect.
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005000700013

Antinociceptive effects of the essential oil of Croton zehntneri in mice
Provedor de dados: Brazilian Journal of Medical and Biological Research
Autores: Oliveira,A.C.; Leal-Cardoso,J.H.; Santos,C.F.; Morais,S.M.; Coelho-de-Souza,A.N.
Croton zehntneri is an aromatic plant native to Northeastern Brazil, where it is often used in folk medicine. In the present study the antinociceptive effects of the essential oil of Croton zehntneri (EOCz) were evaluated in mice. EOCz administered orally at doses of 100 and 300 mg/kg reduced paw licking time in the second phase of the formalin test from the control value of 41.61 ± 8.62 to 12.01 ± 7.97 and 6.57 ± 3.42 s, respectively. During the first phase of the formalin test only 300 mg/kg induced a significant alteration (from 58.2 ± 7.02, control, to 28.7 ± 4.73 s). The number of contortions in response to intraperitoneal injections of acetic acid did not differ significantly between controls (80.6 ± 9.01) and experimental (300 mg/kg body weight)...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Croton zehntneri; Essential oil; Analgesic; Antinociception; Formalin test; Hot-plate test.
Ano: 2001
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001001100016

Antinociceptive activity of Thyme (Thymus vulgaris L.) and interactions with neurotropics and analgesics
Provedor de dados: Brazilian Journal of Pharmaceutical Sciences
Autores: Rašković,Aleksandar Lazar; Kvrgić,Maja Petar; Tomas,Ana Drago; Stilinović,Nebojša Petar; Čabarkapa,Velibor Spasoje; Stojšić-Milosavljević,Anastazija Ðurica; Kusturica,Milica Nada Paut; Rakić,Dušica Branko.
The plant world represents an important source of potential therapeutic agents, but concomitant administration of herbal and conventional medications may result in interactions with subsequent beneficial or adverse effects. This study was designed to examine the analgesic effect of thyme tincture and thyme syrup, two commonly used thyme formulations, and their interactions with codeine, paracetamol, pentobarbital and diazepam in mice. The identification and quantification of thymol and carvacrol were carried out by GC/MS and GC/FID. The analgesic activity was studied using a hot plate method. Effects of thyme syrup on diazepam-induced motor coordination impairment in rotarod test and on pentobarbital-induced sleeping time were also determined. Thymol...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Thymus vulgaris; Hot plate; Analgesic; Interactions; Pentobarbital; Diazepam.
Ano: 2020
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100634

Synthesis of some novel pyrimidine, thiophene, coumarin, pyridine and pyrrole derivatives and their biological evaluation as analgesic, antipyretic and anti-inflammatory agents
Provedor de dados: Brazilian Journal of Pharmaceutical Sciences
Autores: El-Sharkawy,Karam Ahmed; AlBratty,Mohammed Mofreh; Alhazmi,Hassan Ahmad.
Pyrimidine derivative 3 was afforded through the reaction of compound (1) with 5-ureidohydantion (2). Product 3 underwent a cyclization to produce fused pyrimidine derivative 7, although the latter product 7 was synthesized through one step via the reaction of compound (1) with 5-ureidohydantion (2) using another catalyst. Compound 3 was oriented to react with cyclic ketones 8a,b in the presence of elemental sulfur, salicylaldehyde (10), aryldiazonium chlorides 12a,b and ω-bromo-4-methoxy- acetophenone (14), which afforded, fused thiophene derivatives 9a,b, coumarin derivative 11, arylhdrazono derivatives 13a,b and 4-methoxyphenyl butenyl derivative 15, respectively. The latter product 15 was reacted with either potassium cyanide (16a) or potassium...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Pyrimidine derivative; Thiophene; Coumarin; Pyridine; Pyrrole; Analgesic; Antipyretic and anti-inflammatory agents.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000400603

In vivo analgesic and anti-inflammatory effects of the essential oil from Tanacetum balsamita L.
Provedor de dados: Brazilian Journal of Pharmaceutical Sciences
Autores: Sharif,Maryam; Najafizadeh,Parvaneh; Asgarpanah,Jinous; Mousavi,Zahra.
Tanacetum balsamita locally called Shahesparam is an aromatic plant that grows widely in Azerbaijan Province, Iran. Due to the widespread use of T. balsamita as a pain killer and relief of inflammatory based disorders in Iranian folk medicine and considering the high content of essential oil in T. balsamita aerial parts, we were prompted to investigate the anti-nociceptive and anti-inflammatory properties of T. balsamita essential oil (TBEO) for the first time. The carrageenan-induced Paw Edema was used for inflammation evaluation in rat, and hot-plate method was used for pain assessment in mice. Different doses of TBEO were administered. Morphine and Mefenamic acid were used as the standard drugs in anti-nociceptive and anti-inflammatory evaluation tests,...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Tanacetum balsamita; Essential oil; Analgesic; Antiinflammatory.
Ano: 2020
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100556

Effects of tramadol on tear production, intraocular pressure, and pupil size in dogs: clinical study
Provedor de dados: Ciência Rural
Autores: Ruiz,Thaís; Peres,Thalita Priscila da Silva; Campos,Wilma Neres da Silva; Sorte,Eveline da Cruz Boa; Ribeiro,Alexandre Pinto.
This study aimed to evaluate the effects of tramadol on tear production, intraocular pressure (IOP) and pupil diameter (PD) in healthy dogs. Dogs were randomly assigned to receive 4mg kg-1 (n=11) and 6mg kg-1 (n=11) of tramadol hydrochloride intramuscularly. Tear production (Schirmer tear test, STT-1), IOP (applanation tonometry) and the PD (electronic pachymetry) were assessed before, 30 and 60 minutes after administration of tramadol. Data were compared by analysis of variance for repeated measures (P&lt;0.05). Parameters evaluated before, at 30 and 60min, in dogs treated with 4 and 6mg kg-1, were respectively: (STT-1) 22.50±3.38, 21.14±3.94 and 21.09±2.99mm min-1; and 23.05±3.73,22.64±3.76 and 22.82±3.25mm min-1. (IOP) 18.14±2.68, 17.68±2.59 and...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Opioid; Analgesic; Miosis; Keratoconjunctivitis sicca.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782015000400724