Consulta: subjectFacets:"Angiotensin-converting enzyme inhibitors"
Registros recuperados: 2
Data/hora: 10/06/2024 16:03:18

Antagonism of the acute hemodynamic effects of captopril in decompensated congestive heart failure by aspirin administration
Provedor de dados: Brazilian Journal of Medical and Biological Research
Autores: Viecili,P.R.; Pamplona,D.; Park,M.; Silva,S.R.; Ramires,J.A.F.; Da Luz,P.L.
The concomitant use of angiotensin-converting enzyme inhibitors and aspirin may cause pharmacological antagonism. Hence we examined the effect of aspirin on the neurohormonal function and hemodynamic response to captopril in heart failure patients. Between April 1999 and August 2000, 40 patients were randomized into four equal groups: 1) captopril, 2) aspirin, 3) captopril-aspirin: captopril was given alone on the first day, followed by aspirin on the remaining days, and 4) aspirin-captopril: aspirin was given alone on the first day, followed by captopril on the remaining days. Hemodynamic, norepinephrine and prostaglandin measurements were performed pre- and post-medication for 4 days. Captopril (50 mg) was given orally every 8 h and 300 mg aspirin was...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Pharmacological antagonism; Aspirin; Angiotensin-converting enzyme inhibitors; Decompensated heart failure; Hemodynamics and neurohormonal changes.
Ano: 2003
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003000600013

Angiotensin-converting enzyme inhibition by lisinopril enhances liver regeneration in rats
Provedor de dados: Brazilian Journal of Medical and Biological Research
Autores: Ramalho,F.S.; Ramalho,L.N.Z.; Castro-e-Silva Júnior,O.; Zucoloto,S.; Corrêa,F.M.A.
Bradykinin has been reported to act as a growth factor for fibroblasts, mesangial cells and keratinocytes. Recently, we reported that bradykinin augments liver regeneration after partial hepatectomy in rats. Angiotensin-converting enzyme (ACE) is also a powerful bradykinin-degrading enzyme. We have investigated the effect of ACE inhibition by lisinopril on liver regeneration after partial hepatectomy. Adult male Wistar rats underwent 70% partial hepatectomy (PH). The animals received lisinopril at a dose of 1 mg kg body weight-1 day-1, or saline solution, intraperitoneally, for 5 days before hepatectomy, and daily after surgery. Four to six animals from the lisinopril and saline groups were sacrificed at 12, 24, 36, 48, 72, and 120 h after PH. Liver...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Angiotensin-converting enzyme inhibitors; Lisinopril; Bradykinin; Liver regeneration; Cell proliferation; Hepatocyte.
Ano: 2001
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001000100016