Consulta: subjectFacets:"Anti-inflammation"
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Data/hora: 01/06/2024 19:05:13

Effect of a rosmarinic acid supplemented hemodialysis fluid on inflammation of human vascular endothelial cells
Provedor de dados: 56
Autores: Wang,W-J.; Cheng,M-H.; Lin,J-H.; Weng,C-S.
Chronic systemic inflammation and repetitive damage of vascular endothelia by incompatible dialysis system are probable causes of cardiovascular disease in patients on dialysis. The present study aimed to assess in vitro biocompatibility and anti-inflammatory effect of hemodialysis fluid supplemented with rosmarinic acid (RA) using human umbilical vein endothelial cells (HUVEC). HUVECs (5×106 cells/mL) were pre-exposed to 1 μg/mL of lipopolysaccharides (LPS) and incubated with RA-supplemented hemodialysis fluid (HDF). Cytotoxicity was assessed qualitatively by morphologic assessment and quantitatively by MTT assay. Expressions of proinflammatory mediators were assessed using quantitative real-time PCR and production of NO was quantified. Phosphorylation of...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Rosmarinic acid; Hemodialysis fluid; Anti-inflammation; Endothelial cells; LPS.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2017001200606