Consulta: subjectFacets:"Anti-inflammatory agents"
Registros recuperados: 4
Data/hora: 04/06/2024 10:36:49

Anti-inflammatory activity of the apolar extract from the seaweed Galaxaura marginata (Rhodophyta, Nemaliales)
Provedor de dados: 80
Autores: Rozas,E.; Freitas,J. C.
The red seaweed Galaxaura marginata (Ellis &amp;amp; Solander) Lamouroux, well known by the antibacterial activity of its polar extract and the cytotoxic activity of its oxygenated desmosterol, showed anti-inflammatory action in its apolar fraction. Topical anti-inflammatory activity was observed in samples collected at São Sebastião channel, northern littoral of São Paulo State, Brazil. The apolar extract and its fractions obtained through Thin-Layer Chromatography (TLC) reduced the topical inflammation produced by croton oil in mouse ear. Such data indicated that the apolar extract from the marine red alga G. marginata displayed anti-inflammatory activity (since 1mg/ear extract reduced 95±0.5% inflammation), which could be the result of the synergic...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Seaweed; Galaxaura marginata; Inflammation; Croton oil; Edema; Anti-inflammatory agents.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992007000200011

Antiedematogenic activity of the indole derivative N-salicyloyltryptamine in animal models
Provedor de dados: 42
Autores: SOUSA-NETO,BENEDITO P.; GOMES,BRUNO S.; CUNHA,FRANCISCO V.M.; ARCANJO,DANIEL D.R.; GUTIERREZ,STANLEY J.C.; SOUZA,MARIA F.V.; ALMEIDA,FERNANDA R.C.; OLIVEIRA,FRANCISCO A.
ABSTRACT The N-salicyloyltryptamine (NST) is an indole derivative compound analogue to the alkaloid N-benzoyltryptamine. In the present study, the antiedematogenic activity of NST was investigated in animal models. Firstly, the acute toxicity for NST was assessed according to the OECD Guideline no. 423. The potential NST-induced antiedematogenic activity was evaluated by carrageenan-induced paw edema in rats, as well as by dextran-, compound 48/80-, histamine-, serotonin-, capsaicine-, and prostaglandin E2-induced paw edema in mice. The effect of NST on compound 48/80-induced ex vivo mast cell degranulation on mice mesenteric bed was investigated. No death or alteration of behavioral parameters was observed after administration of NST (2000 mg/kg, i.p.)...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Anti-inflammatory agents; Edema; Indoles; Inflammation mediators; N-salicyloyltryptamine.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652018000100185

Biological evaluation of novel 6-Arylbenzimidazo [1,2-c] quinazoline derivatives as inhibitors of LPS-induced TNF- alpha secretion
Provedor de dados: 48
Autores: GALARCE,GLORIA D; FONCEA,ROCÍO E; EDWARDS,ANA M; PESSOA-MAHANA,HERNÁN; PESSOA-MAHANA,CARLOS D; EBENSPERGER,ROBERTO A.
This study describes the effect of novel 6-Arylbenzimidazo [1,2-c] quinazoline derivatives as tumor necrosis factor alpha (TNF-á) production inhibitors. The newly synthesized compounds were tested for their in vitro ability to inhibit the lipolysaccharide (LPS) induced TNF-á secretion in the human promyelocytic cell line HL-60. The compound 6-Phenyl-benzimidazo [1,2-c] quinazoline, coded as Gl, resulted as the most potent inhibitor and with no significant cytotoxic activity. Thus, 6-Arylbenzimidazo [1,2-c] quinazoline derivatives may have a potential as anti-inflammatory agents
Tipo: Journal article
Palavras-chave: Anti-inflammatory agents; Benzimidazoquinazoline derivatives; TNF-á inhibitors.
Ano: 2008
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602008000100006

Dendrimers as anti-inflammatory agents
Provedor de dados: 60
Autores: Avti,Pramod K.; Kakkar,Ashok.
Dendrimers constitute an intriguing class of macromolecules which find applications in a variety of areas including biology. These hyperbranched macromolecules with tailored backbone and surface groups have been extensively investigated as nanocarriers for gene and drug delivery, by molecular encapsulation or covalent conjugation. Dendrimers have provided an excellent platform to develop multivalent and multifunctional nanoconjugates incorporating a variety of functional groups including drugs which are known to be anti-inflammatory agents. Recently, dendrimers have been shown to possess anti-inflammatory properties themselves. This unexpected and intriguing discovery has provided an additional impetus in designing novel active pharmaceutical agents. In...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Dendrimers; Nanocarriers; Anti-inflammatory agents; Cyclooxygenase (COX-2); Inducible nitric oxide synthase (iNOS); Pro-inflammatory cytokines.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502013000700006