Consulta: subjectFacets:"Antifungal susceptibility"
Registros recuperados: 7
Data/hora: 10/06/2024 06:25:11

Microdilution procedure for antifungal susceptibility testing of Paracoccidioides brasiliensis to amphotericin b and itraconazole
Provedor de dados: 80
Autores: Takahagi-Nakaira,E; Sugizaki,MF; Peraçoli,MTS.
In vitro tests employing microdilution to evaluate fungal susceptibility to antifungal drugs are already standardized for fermentative yeasts. However, studies on the susceptibility of dimorphic fungi such as Paracoccidioides brasiliensis employing this method are scarce. The present work introduced some modifications into antifungal susceptibility testing from the European Committee on Antimicrobial Susceptibility Testing (EUCAST), concerning broth medium and reading time, to determine minimal inhibitory concentration (MIC) of amphotericin B and itraconazole against Paracoccidioides brasiliensis. Yeast-like cells of P. brasiliensis (Pb18 strain) were tested for susceptibility to amphotericin B and itraconazole in RPMI 1640 medium, supplemented with 2%...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Amphotericin B; Itraconazole; P. brasiliensis; Antifungal susceptibility.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992009000400010

Clinical and microbiological characteristics of cryptococcosis at an university hospital in China from 2013 to 2017
Provedor de dados: 55
Autores: Fang,Lan-fang; Zhang,Piao-piao; Wang,Jie; Yang,Qing; Qu,Ting-ting.
ABSTRACT  Background: This study aims to explore the epidemiology, clinical profile and strain characteristics of cryptococcosis from 2013 to 2017 in a major teaching hospital in China.  Methods: Trends in antifungal drug susceptibility of 217 consecutive non-repetitive cryptococcal isolates collected from patients of an university hospital in China were analyzed between 2013 and 2017. Of those, 98 isolates were conserved for identification by internal transcribed spacer (ITS) sequencing and matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) system. Multilocus sequence typing (MLST) was used to designate molecular types. Clinical characteristics of the 98 patients with cryptococcosis during the period of 2013-2017...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Cryptococcosis; Cryptococcus neoformans; Multilocus sequence typing (MLST); Antifungal susceptibility; Human immunodeficiency virus (HIV).
Ano: 2020
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702020000100007

Species distribution and antifungal susceptibility patterns of Candida isolates from a public tertiary teaching hospital in the Eastern Cape Province, South Africa
Provedor de dados: 56
Autores: Mnge,P.; Okeleye,B.I.; Vasaikar,S.D.; Apalata,T.
Candida species are the leading cause of invasive fungal infections, and over the past decade there has been an increased isolation of drug resistant Candida species. This study aimed to identify the species distribution of Candida isolates and to determine their unique antifungal susceptibility and resistance patterns. During a cross-sectional study, 209 Candida isolates (recovered from 206 clinical samples) were collected and their species distribution was determined using ChromAgar Candida. The Vitek-2 system (Biomerieux, South Africa) was used to determine minimum inhibitory concentrations (MICs) to azoles (fluconazole, voriconazole), echinocandins (caspofungin, micafungin), polyenes (amphotericin B) and flucytosine. Four species of Candida were...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Candida species; Distribution; Antifungal susceptibility; Identification; South Africa.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2017000600702

Invasive infection due to Saprochaete capitata in a young patient with hematological malignancies
Provedor de dados: 58
Autores: Parahym,Ana Maria Rabelo de Carvalho; Rolim Neto,Pedro José; Silva,Carolina Maria da; Domingos,Igor de Farias; Gonçalves,Sarah Santos; Leite,Edinalva Pereira; Morais,Vera Lúcia Lins de; Macêdo,Danielle Patrícia Cerqueira; Lima Neto,Reginaldo Gonçalves de; Neves,Rejane Pereira.
We report a case of invasive infection due to Saprochaete capitata in a patient with hematological malignancies after chemotherapy treatment and empiric antifungal therapy with caspofungin. Although severely immunocompromised the patient survived been treated with amphotericin B lipid complex associated with voriconazole.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Invasive infection; Saprochaete capitata; Geotrichum capitatum; Hematological malignancies; Antifungal susceptibility.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822015000200527

Nosocomial candidiasis in Rio de Janeiro State: Distribution and fluconazole susceptibility profile
Provedor de dados: 58
Autores: Neufeld,Paulo Murillo; Melhem,Marcia de Souza Carvalho; Szeszs,Maria Walderez; Ribeiro,Marcos Dornelas; Amorim,Efigênia de Lourdes Teixeira; Silva,Manuela da; Lazéra,Marcia dos Santos.
One hundred and forty-one Candida species isolated from clinical specimens of hospitalized patients in Rio de Janeiro, Brazil, during 2002 to 2007, were analized in order to evaluate the distribution and susceptibility of these species to fluconazole. Candida albicans was the most frequent species (45.4%), followed by C. parapsilosis sensu lato (28.4%), C. tropicalis (14.2%), C. guilliermondii (6.4%), C. famata (2.8%), C. glabrata (1.4%), C. krusei (0.7%) and C. lambica (0.7%). The sources of fungal isolates were blood (47.5%), respiratory tract (17.7%), urinary tract (16.3%), skin and mucous membrane (7.1%), catheter (5.6%), feces (2.1%) and mitral valve tissue (0.7%). The susceptibility test was performed using the methodology of disk-diffusion in agar...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Candida; Fluconazole; Antifungal susceptibility; Disk diffusion method.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822015000200477

Antifungal activity of topical microemulsion containing a thiophene derivative
Provedor de dados: 58
Autores: Guimarães,Geovani Pereira; Reis,Mysrayn Yargo de Freitas Araújo; Silva,Dayanne Tomaz Casimiro da; Mendonça Junior,Francisco Jaime Bezerra; Converti,Attílio; Pessoa Jr,Adalberto; Damasceno,Bolívar Ponciano Goulart de Lima; Silva,José Alexsandro da.
Fungal infections have become a major problem of worldwide concern. Yeasts belonging to the Candida genus and the pathogenic fungus Cryptococcus neoformans are responsible for different clinical manifestations, especially in immunocompromised patients. Antifungal therapies are currently based on a few chemotherapeutic agents that have problems related to effectiveness and resistance profiles. Microemulsions are isotropic, thermodynamically stable transparent systems of oil, water and surfactant that can improve the solubilization of lipophilic drugs. Taking into account the need for more effective and less toxic drugs along with the potential of thiophene derivatives as inhibitors of pathogenic fungi growth, this study aimed to evaluate the antifungal...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Antifungal susceptibility; Cryptococcus neoformans; Microemulsion; Thiophene derivatives.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822014000200024

Susceptibility testing of Candida albicans isolated from oropharyngeal mucosa of HIV+ patients to fluconazole, amphotericin B and Caspofungin: killing kinetics of caspofungin and amphotericin B against fluconazole resistant and susceptible isolates
Provedor de dados: 58
Autores: Lemos,Janine de Aquino; Costa,Carolina Rodrigues; Araújo,Crystiane Rodrigues de; Souza,Lúcia Kioko Hasimoto e; Silva,Maria do Rosário Rodrigues.
A clear understanding of the pharmacodynamic properties of antifungal agents is important for the adequate treatment of fungal infections like candidiasis. For certain antifungal agents, the determination of Minimal Fungicidal Concentration (MFC) and time kill curve could be clinically more relevant than the determination of the Minimal Inhibitory Concentration (MIC). In this study, MIC and MFC to fluconazole, amphotericin B and caspofungin against C. albicans isolates and the killing patterns obtained with caspofungin and amphotericin B against susceptible and resistant strains to fluconazole were determined. The results of MICs showed that all C. albicans isolates were highly susceptible to amphotericin B, but two isolates were fluconazole resistant. The...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Antifungal susceptibility; Candida albicans; Time kill curves.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822009000100028