Consulta: subjectFacets:"Antitumor"
Registros recuperados: 6
Data/hora: 10/06/2024 18:17:22

The cytotoxic and growth inhibitory effects of palladium(II) complexes on MDA-MB-435 cells
Provedor de dados: 74
Autores: Campanella,Nathália Cristina; Demartini,Mariana da Silva; Torres,Claudia; Almeida,Eduardo Tonon de; Gouvêa,Cibele Marli Cação Paiva.
The antitumorigenic potential of two palladium(II) complexes, [Pd(ca2-o-phen)Cl2 ] - C1 and [Pd(dmba)(dppp)Cl] - C2, was evaluated, using MDA-MB-435 cells, a human breast adenocarcinoma cell-line that does not express the estrogen receptor α (ER-). Growth inhibition and induced alterations in cell-morphology were analyzed. The sulforhodamine B test showed that, compared to control cells, both C1 and C2 significantly inhibited (p &lt; 0.5) cell growth. The maximum effect with both was achieved with 1 µM complexes, after 24 h of treatment. No further cell-growth inhibition was achieved by increasing concentration or incubation time. Cell morphology was analyzed after staining with hematoxylin-eosin (HE). The morphological changes noted in the treated cells...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Adenocarcinoma cells; Antitumor; Breast cancer; Chemotherapy; Coordination complexes.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572012000100023

Spider venom peptides as potential drug candidates due to their anticancer and antinociceptive activities
Provedor de dados: 80
Autores: Wu,Ting; Wang,Meng; Wu,Wenfang; Luo,Qianxuan; Jiang,Liping; Tao,Huai; Deng,Meichun.
Abstract Spider venoms are known to contain proteins and polypeptides that perform various functions including antimicrobial, neurotoxic, analgesic, cytotoxic, necrotic, and hemagglutinic activities. Currently, several classes of natural molecules from spider venoms are potential sources of chemotherapeutics against tumor cells. Some of the spider peptide toxins produce lethal effects on tumor cells by regulating the cell cycle, activating caspase pathway or inactivating mitochondria. Some of them also target the various types of ion channels (including voltage-gated calcium channels, voltage-gated sodium channels, and acid-sensing ion channels) among other pain-related targets. Herein we review the structure and pharmacology of spider-venom peptides that...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Spider venom peptides; Antitumor; Pain; Drug candidates.
Ano: 2019
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992019000100203

Pharmacological characterization of cnidarian extracts from the Caribbean Sea: evaluation of anti-snake venom and antitumor properties
Provedor de dados: 80
Autores: Oliveira,Cláudia S.; Caldeira,Cleópatra A. S.; Diniz-Sousa,Rafaela; Romero,Dolores L.; Marcussi,Silvana; Moura,Laura A.; Fuly,André L.; Carvalho,Cicília de; Cavalcante,Walter L. G.; Gallacci,Márcia; Pai,Maeli Dal; Zuliani,Juliana P.; Calderon,Leonardo A.; Soares,Andreimar M.
Abstract  Background: Cnidarians produce toxins, which are composed of different polypeptides that induce pharmacological effects of biotechnological interest, such as antitumor, antiophidic and anti-clotting activities. This study aimed to evaluate toxicological activities and potential as antitumor and antiophidic agents contained in total extracts from five cnidarians: Millepora alcicornis, Stichodactyla helianthus, Plexaura homomalla, Bartholomea annulata and Condylactis gigantea (total and body wall).  Methods: The cnidarian extracts were evaluated by electrophoresis and for their phospholipase, proteolytic, hemorrhagic, coagulant, fibrinogenolytic, neuromuscular blocking, muscle-damaging, edema-inducing and cytotoxic activities.  Results: All...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Caribbean sea cnidarians; Bioprospection; Antiophidic; Antitumor; Natural products.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992018000100313

Enhancing Antitumor Efficacy of Cisplatin Low Dose by EDTA in Ehrlich Ascetic Carcinoma Bearing Mice
Provedor de dados: 52
Autores: El-Naggar,Sabry Ali; El-Said,Karim Samy; Mobasher,Maysa; Elbakry,Mohamed.
Abstract In a recent study, the treatment of different human cancer cell lines in vitro with ethylene diamine tetra-acetic acid (EDTA) showed a promising anticancer activity which could be a novel promising approach for cancer treatment. The aim of this study is to address the ability of EDTA to enhance the antitumor efficacy of the low dose of cisplatin (Cis) treatment in Ehrlich ascetic carcinoma (EAC) bearing mice. Sixty female albino mice were divided into six groups. The 1st group of mice was served as a negative control. 2nd - 6th groups were inoculated intraperitoneal (i.p) with 2×106 EAC cells/mouse. After one day of inoculation, the 2nd, 3rd and 4th groups were injected daily for 6 days (early treatment) with phosphate buffer saline, low dose of...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Cisplatin; Antitumor; Ethylene diamine tetra-acetic acid (EDTA); Ehrlich ascites carcinoma.
Ano: 2019
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132019000100316

Evaluation of a lipopeptide biosurfactant from Bacillus natto TK-1 as a potential source of anti-adhesive, antimicrobial and antitumor activities
Provedor de dados: 58
Autores: Cao,Xiao-Hong; Liao,Zhen-Yu; Wang,Chun-Ling; Yang,Wen-Yan; Lu,Mei-Fang.
A lipopeptide biosurfactant produced by Bacillus natto TK-1 has a strong surface activity. The biosurfactant was found to be an anti-adhesive agent against several bacterial strains, and also showed a broad spectrum of antimicrobial activity. The biosurfactant induced a significant reduction in tumor cells viability in a dose- dependent manner.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Biosurfactant; Anti-adhesive; Antimicrobial activity; Antitumor.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822009000200030

Antineoplasic activity of Agaricus brasiliensis basidiocarps on different maturation phases
Provedor de dados: 58
Autores: Mourão,Francielly; Linde,Giani Andrea; Messa,Valdeci; Cunha Júnior,Paulo Luiz da; Silva,Aristeu Vieira da; Eira,Augusto Ferreira da; Colauto,Nelson Barros.
The fungus Agaricus brasiliensis is a Basidiomycete studied because of its immunomodulation and/or antitumor substances. The objective of this study was to verify the Agaricus brasiliensis antineoplasic activity in vivo on different basidiocarp maturation phases on Sarcoma 180 cells implanted in mice. Sarcoma cells were implanted in mice and after seven days mice were divided in three groups. The first group was treated with saline solution, the second group was treated with closed basidiocarp extract solution and the third group was treated with opened basidiocarp extract solution. After 30 days of being daily orally treated with these three solutions all animals suffered euthanasia, and the splenic index, tumor mass and volume were determined. No...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Agaricus blazei; Basidiome; Active principle; Antitumor; Fungus extract.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822009000400022