Consulta: subjectFacets:"Antiviral agents"
Registros recuperados: 3
Data/hora: 03/06/2024 18:12:41

Antiviral activity of animal venom peptides and related compounds
Provedor de dados: 80
Autores: Mata,Élida Cleyse Gomes da; Mourão,Caroline Barbosa Farias; Rangel,Marisa; Schwartz,Elisabeth Ferroni.
Abstract Viruses exhibit rapid mutational capacity to trick and infect host cells, sometimes assisted through virus-coded peptides that counteract host cellular immune defense. Although a large number of compounds have been identified as inhibiting various viral infections and disease progression, it is urgent to achieve the discovery of more effective agents. Furthermore, proportionally to the great variety of diseases caused by viruses, very few viral vaccines are available, and not all are efficient. Thus, new antiviral substances obtained from natural products have been prospected, including those derived from venomous animals. Venoms are complex mixtures of hundreds of molecules, mostly peptides, that present a large array of biological activities and...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Antiretroviral agents; Antiviral agents; HIV; Scorpion venom; Snake venom; Amphibian venom; Insect venom; Marine animal peptides.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992017000100200

Antiviral activities of extracts and phenolic components of two Spondias species against dengue virus
Provedor de dados: 80
Autores: Silva,Ara; Morais,SM; Marques,MMM; Lima,DM; Santos,SCC; Almeida,RR; Vieira,IGP; Guedes,MIF.
In recent years, the search for natural plant products to fight viral diseases has been increasing. In this work, two Spondias species, namely S. mombin and S. tuberosa, found in Ceará state (Brazil), and their main phenolic components were evaluated against dengue virus. In vitro antiviral tests were performed against type-2 dengue virus by the MTT method and standard cytopathic effect reduction assay in C6/36 cells. Cytotoxicity was also evaluated by MTT. The presence of phenolic compounds quercetin, rutin, and ellagic acid in plant extracts was characterized by HPLC analysis. Both Spondias species extracts and components were nontoxic to the cells whereas rutin and quercetin displayed relevant antiviral activity with IC50 of 362.68 µg/mL and 500 µg/mL,...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Natural products; Phenols; Dengue; Antiviral agents.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992011000400007

Mechanisms of virus resistance and antiviral activity of snake venoms
Provedor de dados: 80
Autores: Rivero,JVR; de Castro,FOF; Stival,AS; Magalhães,MR; Carmo Filho,JR; Pfrimer,IAH.
Viruses depend on cell metabolism for their own propagation. The need to foster an intimate relationship with the host has resulted in the development of various strategies designed to help virus escape from the defense mechanisms present in the host. Over millions of years, the unremitting battle between pathogens and their hosts has led to changes in evolution of the immune system. Snake venoms are biological resources that have antiviral activity, hence substances of significant pharmacological value. The biodiversity in Brazil with respect to snakes is one of the richest on the planet; nevertheless, studies on the antiviral activity of venom from Brazilian snakes are scarce. The antiviral properties of snake venom appear as new promising therapeutic...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Snake venom; Viruses; Antiviral agents.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992011000400005