Consulta: subjectFacets:"Azole resistance"
Registros recuperados: 4
Data/hora: 09/06/2024 17:02:31

Causative Agents of Aspergillosis Including Cryptic Aspergillus Species and A. fumigatus
Provedor de dados: 19
Autores: 豊留, 孝仁; TOYOTOME, Takahito.
アスペルギルス症は深在性真菌感染症の重要な位置を占めている．アスペルギルス症の原因真菌はAspergillus fumigatusが最も重要であるが，そのほかにもAspergillus flavusやAspergillus niger, Aspergillus terreusなども重要な原因菌種である．また，近年になって隠蔽種と呼ばれる各Aspergillus sectionの代表的な種に非常によく似た菌種の存在が認識され，一部のアスペルギルス症の原因となっていることも分かってきた．最近の研究で，それらの菌種間では抗真菌薬に対する感受性や二次代謝産物の産生プロファイル (エクソメタボローム) が異なることも明らかとなってきた．一方，治療中のA. fumigatusアゾール耐性化や近年の欧州を中心とした環境中アゾール耐性A. fumigatusの出現も報告され，これら菌種を正確に同定し，加えて感受性を評価することの重要性が高まってきている． 本総説ではA. fumigatusを含めたアスペルギルス症原因菌種，特に隠蔽種について触れ，エクソメタボローム解析を利用した同定の可能性を述べる．加えて，A. fumigatusアゾール系抗真菌薬耐性について最近の報告を交えて概説したい
Palavras-chave: Aspergillosis; Aspergillus spp.; Azole resistance; Cryptic species; Secondary metabolites.
Ano: 2016
URL: http://ir.obihiro.ac.jp/dspace/handle/10322/4396

Proteomic analysis of cytosolic proteins associated with petite mutations in Candida glabrata
Provedor de dados: 56
Autores: Loureiro y Penha,C.V.; Kubitschek,P.H.B.; Larcher,G.; Perales,J.; Rodriguez León,I.; Lopes-Bezerra,L.M.; Bouchara,J.P.
The incidence of superficial or deep-seated infections due to Candida glabrata has increased markedly, probably because of the low intrinsic susceptibility of this microorganism to azole antifungals and its relatively high propensity to acquire azole resistance. To determine changes in the C. glabrata proteome associated with petite mutations, cytosolic extracts from an azole-resistant petite mutant of C. glabrata induced by exposure to ethidium bromide, and from its azole-susceptible parent isolate were compared by two-dimensional polyacrylamide gel electrophoresis. Proteins of interest were identified by peptide mass fingerprinting or sequence tagging using a matrix-assisted laser desorption/ionization tandem time-of-flight mass spectrometer. Tryptic...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Candida glabrata; Petite mutations; Cytosolic extracts; Proteomic analysis; Azole resistance.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010001200010

Membrane fluidity and lipid composition of fluconazole resistant and susceptible strains of Candida albicans isolated from diabetic patients
Provedor de dados: 58
Autores: Mishra,Nagendra N.; Prasad,Tulika; Sharma,Neeraj; Gupta,Dwijendra K.
Ten clinical isolates of Candida albicans, five strains belonging to each of fluconazole resistant and susceptible groups isolated from diabetic patients, were studied for the membrane fluidity and lipid composition. Compared to fluconazole susceptible strains, fluconazole resistant ones exhibited enhanced membrane fluidity as measured by fluorescence polarization technique. The increased membrane fluidity was reflected in the decreased p-values exhibited by the resistant strains. On the other hand, susceptible isolates contained higher amount of ergosterol, almost twice as compared to resistant isolates which might have contributed to their lower membrane fluidity. However, no significant alteration was observed in the phospholipid and fatty acid...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Membrane fluidity; Lipid composition; Azole resistance; Diabetic patients.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822008000200004

Synergistic effects of tacrolimus and azole antifungal compounds in fluconazole-susceptible and fluconazole-resistant Candida glabrata isolates
Provedor de dados: 58
Autores: Denardi,Laura Bedin; Mario,Débora Alves Nunes; Loreto,Érico Silva; Santurio,Janio Morais; Alves,Sydney Hartz.
In vitro interaction between tacrolimus (FK506) and four azoles (fluconazole, ketoconazole, itraconazole and voriconazole) against thirty clinical isolates of both fluconazole susceptible and -resistant Candida glabrata were evaluated by the checkerboard microdilution method. Synergistic, indifferent or antagonism interactions were found for combinations of the antifungal agents and FK506. A larger synergistic effect was observed for the combinations of FK506 with itraconazole and voriconazole (43%), followed by that of the combination with ketoconazole (37%), against fluconazole-susceptible isolates. For fluconazole-resistant C. glabrata, a higher synergistic effect was obtained from FK506 combined with ketoconazole (77%), itraconazole (73%), voriconazole...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Candida glabrata; Azole resistance; FK506; Combination therapy.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822015000100125