Consulta: subjectFacets:"Bioavailability"
Registros recuperados: 28
Data/hora: 09/06/2024 10:39:47

Efecto ambiental y económico-social por la aplicación de biosólidos de origen urbano como mejoradores de suelos agrícolas.
Provedor de dados: 32
Autores: González Flores, Eduardo.
La generación y disposición final de los biosólidos producidos en las plantas de tratamiento de aguas residuales, es un grave problema ambiental. La aplicación en suelos agrícolas es una opción viable por su contenido de materia orgánica, N, P y micronutrimentos. La principal restricción es su contenido de metales pesados. En la ciudad de Puebla de Zaragoza, México, los biosólidos generados se aplican en suelos agrícolas de comunidades rurales cercanas. Los suelos son delgados y de baja productividad y se cultiva principalmente maíz. El objetivo del presente trabajo fue evaluar los efectos ambientales, económicos y sociales producidos por la aplicación de biosólidos en los agroecosistemas de la comunidad La Paz Tlaxcolpan, Puebla. Se tomaron muestras de...
Palavras-chave: Metabolismo social; Biodisponibilidad; Biosólidos; Metales pesados; Agroecosistema; Social metabolism; Bioavailability; Biosolids; Heavy metals; Agroecosystem; Doctorado; EDAR; Estrategias para el Desarrollo Agrícola Regional.
Ano: 2011
URL: http://hdl.handle.net/10521/531

Efecto ambiental y económico-social por la aplicación de biosólidos de origen urbano como mejoradores de suelos agrícolas.
Provedor de dados: 32
Autores: González Flores, Eduardo.
La generación y disposición final de los biosólidos producidos en las plantas de tratamiento de aguas residuales, es un grave problema ambiental. La aplicación en suelos agrícolas es una opción viable por su contenido de materia orgánica, N, P y micronutrimentos. La principal restricción es su contenido de metales pesados. En la ciudad de Puebla de Zaragoza, México, los biosólidos generados se aplican en suelos agrícolas de comunidades rurales cercanas. Los suelos son delgados y de baja productividad y se cultiva principalmente maíz. El objetivo del presente trabajo fue evaluar los efectos ambientales, económicos y sociales producidos por la aplicación de biosólidos en los agroecosistemas de la comunidad La Paz Tlaxcolpan, Puebla. Se tomaron muestras de...
Palavras-chave: Metabolismo social; Biodisponibilidad; Biosólidos; Metales pesados; Agroecosistema; Social metabolism; Bioavailability; Biosolids; Heavy metals; Agroecosystem; Doctorado; EDAR; Estrategias para el Desarrollo Agrícola Regional.
Ano: 2011
URL: http://hdl.handle.net/10521/531

The effects of ethylene on the HCl-extractability of trace elements during soybean seed germination
Provedor de dados: 69
Autores: Liu,Chunming; Zhao,Yixin; Liu,Jianfeng; Gen,Wanting; Cheng,Yunqing.
Background Ethylene is capable of promoting seed germination in some plant species. Mobilization of metals such as Fe, Cu, Mn, and Zn in mature seeds takes place when seeds are germinating. However, whether ethylene is involved in the regulation of soybean seed germination and metal element mobilization during early seed germination stage remains unknown. In the present study, seeds were treated with ethylene synthesis inhibitor aminoethoxyvinylglycine (AVG) and ethylene precursor 1-aminocyclopropane-1-carboxylic acid (ACC), and double distilled H2O (ddH(2)0) treatment was used as control. Ethylene emission, ACC synthase (ACS) expression, ACS enzyme activity and Ca, Zn, Mn, Cu and Fe content in hypocotyls were qualified to analyze the relationship between...
Tipo: Journal article
Palavras-chave: ACC synthase; Bioavailability; Ethylene; Metallic elements; Seed germination; Soybean.
Ano: 2015
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-34582015000500001

Cycle du mercure en estuaire, baie de Seine et pays de Caux
Provedor de dados: 5
Autores: Laurier, Fabien.
The Seine estuary and its adjacent region Pays de Caux are two significant sources of mercury for coastal marine environments. It is carried through fluvial means for the Seine bay and through karstic fresh water emergences for Pays de Caux's coastal area.  Mercury cycle in the Seine estuary and bay is affected by additional anthropical activities. The estuary's maximal turbidity area acts like a trap and a chemical reactor for fluvial mercury. Within this area, we can confirm: (i) the non conservative behaviour of dissolved mercury; (ii) mercury enrichment of particles when comparing the Seine's and marine environment and we suggest mercury particle redistribution from the organic fraction to the oxyhydroxydes fraction. A large fraction of mercury is...
Tipo: Text
Palavras-chave: Bay of Seine; Pays de Caux; Estuary; Coastal zone; Speciation; Bioavailability; Mercury; Pays de Caux; Seine; Estuaire; Emergence; Zone côtière; Spéciation; Biodisponibilité; Mercure.
Ano: 2001
URL: http://archimer.ifremer.fr/doc/2001/these-1842.pdf

The impact of groundwater discharges on mercury partitioning, speciation and bioavailability to mussels in a coastal zone (Reprinted from Marine Chemistry, vol 104, pg 143-155, 2007)
Provedor de dados: 5
Autores: Laurier, Fabien; Cossa, Daniel; Beucher, Charlotte; Breviere, Emily.
The Mussel Watch program conducted along the French coasts for the last 20 years indicates that the highest mercury concentrations in the soft tissue of the blue mussel (Mytilus edulis) occur in animals from the eastern part of Seine Bay on the south coast of the English Channel, the "Pays de Caux". This region is characterized by the presence of intertidal and submarine groundwater discharges, and no particular mercury effluent has been reported in its vicinity. Two groundwater emergence systems in the karstic coastal zone of the Pays de Caux (Etretat and Yport with slow and fast water percolation pathways respectively) were seasonally sampled to study mercury distribution, partitioning and speciation in water. Samples were also collected in the...
Tipo: Text
Palavras-chave: Mussel; Estuaries; Groundwater seepage; Bioavailability; Speciation; Mercury.
Ano: 2007
URL: http://archimer.ifremer.fr/doc/2007/publication-4704.pdf

The impact of groundwater discharges on mercury partitioning, speciation and bioavailability to mussels in a coastal zone
Provedor de dados: 5
Autores: Laurier, Fabien; Cossa, Daniel; Beucher, Charlotte; Breviere, Emily.
The Mussel Watch program conducted along the French coasts for the last 20 years indicates that the highest mercury concentrations in the soft tissue of the blue mussel (Mytilus edulis) occur in animals from the eastern part of Seine Bay on the south coast of the English Channel, the "Pays de Caux". This region is characterized by the presence of intertidal and submarine groundwater discharges, and no particular mercury effluent has been reported in its vicinity. Two groundwater emergence systems in the karstic coastal zone of the Pays de Caux (Etretat and Yport with slow and fast water percolation pathways respectively) were seasonally sampled to study mercury distribution, partitioning and speciation in water. Samples were also collected in the...
Tipo: Text
Palavras-chave: Mussel; Estuaries; Groundwater seepage; Bioavailability; Speciation; Mercury.
Ano: 2007
URL: https://archimer.ifremer.fr/doc/2007/publication-3113.pdf

Waterborne nickel bioaccumulation in Gammarus pulex: Comparison of mechanistic models and influence of water cationic composition
Provedor de dados: 5
Autores: Lebrun, Jeremie D.; Perret, Marine; Uher, Emmanuelle; Tusseau-vuillemin, Marie-helene; Gourlay-france, Catherine.
The biodynamic and saturation models offer promising lines of enquiry to predict the bioaccumulation of metals by aquatic organisms. However, in order to construct these models, the accumulation strategies have to be defined for each metal/organism couple in controlled conditions. This study aims at modelling the waterborne bioaccumulation of Ni and the influence of the water's geochemical properties on this process in a crustacean that is widely distributed in Europe, Gammarus pulex. In the laboratory, G. pulex was exposed to several Ni concentrations (from 0.001 to 100 mg L(-1)) in aquatic microcosms. Our results show that G. pulex is very tolerant to Ni (LC50(48 h) = 477 mg L(-1) Ni). Time course experiments enabled the construction of a biodynamic...
Tipo: Text
Palavras-chave: Biodynamic kinetics; Saturation model; Gammarid; Bioavailability; Water chemistry; Aquatic microcosms.
Ano: 2011
URL: http://archimer.ifremer.fr/doc/00041/15217/18005.pdf

Rôle de l’apport atmosphérique sur les processus de biodégradation et la stoechiométrie de la matière organique dissoute en mer Méditerranée
Provedor de dados: 5
Autores: Djaoudi, Kahina.
Establishing a link between atmospheric deposition and the dissolved organic matter (DOM) pool in the Mediterranean Sea is currently hampered by: (1) a poor knowledge on the surface dissolved phosphate (P) pool, mainly due to low concentrations of dissolved inorganic phosphate (DIP), (2) a critical lack of data on atmospheric fluxes of organic C, N and P and (3) the lack of information on their bioavailability. This PhD thesis aimed at filling these gaps. (1) Relying upon a sensitive determination of DIP, the coverage of the valid dissolved organic phosphate data was enhanced up to 70%, revealing a vertical pattern in the dissolved phosphate biogeochemistry in surface waters. (2) Atmospheric fluxes of soluble organic C, N and P were quantified and were 59...
Tipo: Text
Palavras-chave: Dépôt atmosphérique; Matière organique dissoute; Rapports C:N:P; Nutriments; Mer Méditerranée; Biodisponibilité.; Atmospheric deposition; Dissolved organic matter; C:N:P ratios; Nutrients; Mediterranean Sea; Bioavailability.
Ano: 2018
URL: https://archimer.ifremer.fr/doc/00677/78944/81332.pdf

Relationship between sedimentary organic matter and benthic fauna within the Gulf of Lion: synthesis on the identification of new biochemical descriptors of sedimentary organic nutritional value
Provedor de dados: 5
Autores: Gremare, A; Medernach, L; Debovee, F; Amouroux, Jm; Charles, F; Dinet, A; Vetion, G; Albert, P; Colomines, Jc.
The abilities of several biochemical characteristics of sedimentary organic matter to describe quantitative changes in benthic fauna were assessed based on several surveys carried out within the Gulf of Lion during the last decade. Two sets of high frequency samplings were carried out both inshore and offshore, together with an assessment of seasonal variability along a depth gradient, and a synoptic assessment of mesoscale spatial variability. The considered biochemical parameters were: total organic matter, organic carbon, nitrogen, total proteins, available proteins, carbohydrates, lipids, total and available amino acids. The considered faunal parameters were the abundance and the biomass of both meio- and macrofauna. Our results contribute to unravel...
Tipo: Text
Palavras-chave: Matière organique sédimentée; Benthos; Golfe du Lion; Acides aminés; Biodisponibilité; Sedimentary organics; Benthos; Gulf of Lion; Amino acids; Bioavailability.
Ano: 2003
URL: http://archimer.ifremer.fr/doc/00321/43264/42995.pdf

Marine pollution: Let us not forget beach sand
Provedor de dados: 5
Autores: Galgani, Francois; Ellerbrake, Katrin; Fries, Elke; Goreux, Chantal.
Background: Assessing the chemical or bacterial contamination in marine waters and sediments is a very common approach to evaluate marine pollution and associated risks. However, toxicity and organic pollution of beach sands have not yet been considered, except in adjacent waters. In the present study, the toxicity and the chemical contamination of natural beach sands collected 20 m from the shoreline at two sites located on the Mediterranean Sea (Marseille and La Marana, Corsica) were studied. Results: Up to 16.93% (net percentage) abnormal or dead larvae was observed in elutriates prepared from the urban beach sand sample (Marseille); no significant toxicity was observed in the sample collected from the reference beach in La Marana. Results of Fourier...
Tipo: Text
Palavras-chave: Oyster larvae biotests; Sediments; Infrared spectroscopy; Gas chromatography-mass spectrometry; Microplastics; Polycyclic aromatic hydrocarbons; Mediterranean Sea; Bioavailability; Organic contaminants.
Ano: 2011
URL: http://archimer.ifremer.fr/doc/00353/46442/46186.pdf

PREDICTION OF BIOAVAILABILITY OF CHLORPYRIFOS RESIDUES IN SOIL TO EARTHWORMS
Provedor de dados: 126
Autores: Wu,X.M; Yu,Y.L; Li,M; Long,Y.H; Fang,H; Li,S.N.
An incubation test was conducted to investigate the effect of aging on bioavailability of chlorpyrifos in soil and to assess the feasibility of chemical extraction techniques for predicting bioavailability of chlorpyrifos in soil. Chlorpyrifos was spiked into sterilized soil and aged in microcosms for up to 120 days. The earthworms were incubated in the spiked soils, at 0, 7, 14, 30, 60, and 120 days after spiking, for a period of 7 days. After exposure, chlorpyrifos concentrations in the earthworm tissues were determined. Change in chemical extractability of soil-chlorpyrifos was measured using a several solvent systems including methanol, methanol-water (9:1), acetone-water (5:3), and water. The results show that chemical extractability and earthworm...
Tipo: Journal article
Palavras-chave: Chlorpyrifos; Residue; Soil; Earthworm; Bioavailability; Prediction.
Ano: 2011
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0718-95162011000100004

MOBILITY AND BIOAVAILABILITY OF HEAVY METALS AND METALLOIDS IN SOIL ENVIRONMENTS
Provedor de dados: 126
Autores: Violante,A; Cozzolino,V; Perelomov,L; Caporale,A.G; Pigna,M.
In soil environments, sorption/desorption reactions as well as chemical complexation with inorganic and organic ligands and redox reactions, both biotic and abiotic, are of great importance in controlling their bioavailability, leaching and toxicity. These reactions are affected by many factors such as pH, nature of the sorbents, presence and concentration of organic and inorganic ligands, including humic and fulvic acid, root exudates, microbial metabolites and nutrients. In this review, we highlight the impact of physical, chemical, and biological interfacial interactions on bioavailability and mobility of metals and metalloids in soil. Special attention is devoted to: i) the sorption/desorption processes of metals and metalloids on/from soil components...
Tipo: Journal article
Palavras-chave: Bioavailability; Heavy metals; Metalloid; Adsorption; Desorption; Chemical speciation.
Ano: 2010
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0718-95162010000100005

Determinación del contenido de metales pesados en las fracciones geoquímicas del sedimento superficial asociado a los manglares de la Ciénaga Grande de Santa Marta, Colombia
Provedor de dados: 20
Autores: Espinosa, Luisa Fernanda; Parra, Juan Pablo; Villamil, Carlos.
El ecosistema de manglar de la Ciénaga Grande de Santa Marta (CGSM) ha estado sometido a fuertes presiones antropogénicas que han ocasionado, entre otros, cambios en las características fisicoquímicas de sus sedimentos. En condiciones normales, los sedimentos asociados al manglar generan equilibrios que permiten la retención de metales pesados en distintas formas químicas, al romperse este equilibrio los metales que no son retenidos en la matriz sedimentaria, pueden ser removilizados y hacerse biodisponibles. Con el propósito de establecer el potencial de movilidad y biodisponibilidad  de los metales Cr, Mn, Ni, Cu, Zn, Cd, As y Pb en sedimentos superficiales asociados al manglar en la CGSM, se analizaron sus contenidos en cuatro áreas con diferente grado...
Tipo: Journal Contribution
Palavras-chave: Heavy metals; Sediments; Bioavailability.
Ano: 2011
URL: http://hdl.handle.net/1834/4379

Bioavailability comparison of free and esterified lutein for layer hens
Provedor de dados: 89
Autores: Wu,L; Huang,X; Shi,K; Tan,R.
Lutein supplements are often used to pigment and enrich layer chicken eggs. This experiment was conduced to compare the bioavailability of free and esterified lutein, by depletion method. Forty chickens were randomly divided into two groups. After 2 weeks of washout period, when all birds were fed the same low lutein basal diet, the two groups were fed for another 2 weeks with diets supplemented with free lutein or esterified lutein. Two experimental diets were supplemented with the same amount of 15 mg lutein/kg. On day 0 (baseline) and days 3, 7, and 14, birds fasting morning plasma samples were collected and stored for lutein analysis by high performance liquid chromatography method (HPLC). Results showed that: 1) Plasma lutein concentration increased...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Bioavailability; Depletion method; Free lutein; Layer hens; Lutein ester.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-635X2009000200004

Supplementation of diets for Santa Ines sheep with organic and inorganic zinc sources
Provedor de dados: 96
Autores: Vilela,Flávio Garcia; Zanetti,Marcus Antonio; Saran Netto,Arlindo; Freitas Júnior,José Esler de; Rennó,Francisco Palma; Venturelli,Beatriz Conte; Canaes,Taissa de Souza.
This research was conducted with objective to evaluate the effect of different zinc (Zn) sources and doses in the diet for Santa Ines sheep. Forty lambs at weaning, with 18.4 kg of body weight were supplemented with three different sources of zinc (zinc oxide (ZnO), zinc amino acid and zinc proteinate) and three doses of zinc (200, 400 and 600 mg/kg DM) added to the basal diet. At every 28 days, animals were weighted and blood samples were collected for analyses of zinc (Zn), alkaline phosphatase and immunoglobulin G (IgG) and M (IgM). At the end of experiment, liver samples were collected for determination of the hepatic zinc levels. Zinc was analyzed with atomic absorption spectrophotometer, while phosphatase alkaline and immunoglobulins G and M were...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Bioavailability; Immunoglobulin; Lambs; Minerals.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-35982012000900023

PHOSPHORUS IN ORGANIC WASTE-SOIL SYSTEMS
Provedor de dados: 127
Autores: Fuentes,Bárbara; Bolan,Nanthi; Naidu,Ravi; Mora,María de la Luz.
Increases in the generation of organic wastes, in addition to decreases in natural resources, make it necessary to recycle these waste materials. In soils, the application of wastes as organic fertilizers, allows to reincorporate nutrients to the biogeochemical cycles. The application of wastes in agriculture has carried out with it problems associated with phosphorus (P) overapplication in soils and contamination of water bodies. Phosphorus inside the waste matrix forms organic and inorganic compounds which have different bioavailabilities. The more important factors that influence the bioavailability of P in soils, organic wastes and soil-organic waste amendments are: the soil solution pH, adsorption reactions, organic matter, phosphatase activity and...
Tipo: Journal article
Palavras-chave: Phosphorus; Bioavailability; Compost; Manure.
Ano: 2006
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0718-27912006000200006

The ingestión of a Nectandra membranácea extract changes the bioavailability of technetium-99m radiobiocomplex in rat organs
Provedor de dados: 48
Autores: RAMOS FARÍAS MORENO,SILVANA; ARNOBIO,ADRIANO; CARVALH0,JORGE JOSÉ DE; NASCIMENT0,LUCIA; OLIVEIRA TIMOTEO,MARGARETH; OLEJ,BENI; KAZAN ROCHA,EMELY; PEREIRA,MARIO; BERNARDO-FILH0,MARIO; QUERINO DE ARAÚJO CALDAS,LUIZ.
The radiobiocomplexes labeled with technetium-99m (Tc-99m) have been widely used in nuclear medicine in single photon emission computed tomography and in basic research. The aim of this study was to assess the influence of a Nectandra membranácea extract on the bioavailability of the sodium pertechnetate (Na99mTc0(4)) radiobiocomplex in rat organs. The animals were treated with a N. membranácea extract (30 mg/ ml), for 6 days. Na99mTc0(4) was injected, the organs were isolated and weighed, and the radioactivity was determined in each organ (%ATI/organ). The %ATI/organ was divided by the mass of each organ to calculate the %ATI/g. A significant increase of the %ATI/organ of Na99mTc0(4) was observed in muscle and thyroid as well as in the %ATI/g in the...
Tipo: Journal article
Palavras-chave: Nectandra membranácea; Bioavailability; Sodium pertechnetate; Radiobiocomplex.
Ano: 2007
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602007000200004

Antioxidant flavonols from fruits, vegetables and beverages: measurements and bioavailability
Provedor de dados: 48
Autores: CROZIER,ALAN; BURNS,JENNIFER; AZIZ,AZLINA A; STEWART,AMANDA J; RABIASZ,HELENA S; JENKINS,GARETH I; EDWARDS,CHRISTINE A; LEAN,MICHAEL EJ.
Flavonols are polyphenolic secondary plant metabolites that are present in varying levels in commonly consumed fruits, vegetables and beverages. Flavonols have long held an interest for nutritionists, which has increased following a Dutch study in the early 1990’s showing that dietary intake of flavonols was inversely correlated with the incidence of coronary heart disease. The main factors that have hindered workers in the field of flavonol research are (i) the accurate measurement of these compounds in foods and biological samples, and (ii) a dearth of information on their absorption and metabolism. This review aims to highlight the work of the authors in attempting to clarify the situation. The sensitive and selective HPLC procedure to identify and...
Tipo: Journal article
Palavras-chave: Bioavailability; Dietary antioxidants; Flavones; Flavonols; HPLC analysis.
Ano: 2000
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602000000200007

Drug interaction with radiopharmaceuticals: a review
Provedor de dados: 52
Autores: Bernardo-Filho,Mario; Santos-Filho,Sebastião David; Moura,Egberto Gaspar de; Maiworm,Adalgisa Ieda; Orlando,Margarida Maria de Camões; Penas,Maria Expósito; Cardoso,Valbert Nascimento; Bernardo,Luciana Camargo; Brito,Lavínia de Carvalho.
Clinical images are worthwhile in Health Sciences and their analysis and correct interpretation aid the professionals,such as physicians, physiotherapists and occupational therapists, to make decisions and take subsequent therapeutic and/or rehabilitation measures. Other factors, besides the state of the disease, may interfere and affect the bioavailability of the radiopharmaceuticals (radiobiocomplexes) and the quality of the SPECT and PET images. Furthermore, the labeling of some of these radiobiocomplexes, such as plasma proteins, white blood cells and red blood cells, with 99mT, can also be modified. These factors include drugs (synthetic and natural) and dietary conditions, as well as some medical procedures (invasive or non-invasive), such as...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Drug interaction; Blood constituents; Radiobiocomplexes; Bioavailability.
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132005000700003

Pharmacodynamic and Pharmacokinetic Studies of β-Cyclodextrin:Dexamethasone Acetate Complexes in Mice
Provedor de dados: 52
Autores: Rodrigues,Patrik Oening; Becker,Ana Cláudia; Dellagnelo,Viviane Aparecida; Benetti,Cibele Nabhan; Pereira,Eduardo Manoel; Wagner,Theodoro Marcel; Silva,Marcos Antonio Segatto.
The aim of this study was to evaluate the in vivo activity of the anti-inflammatory and analgesic effects of a suspension of the complex composed of dexamethasone acetate (DMA) with β-cyclodextrin in comparison to a suspension of the pure DMA. Solid complexes prepared by different methods were evaluated in pharmacodynamics and pharmacokinetics studies. The pharmacodynamic effect was investigated although the capacity of the inhibited the inflammation. Models of abdominal constriction, carrageenan-induced paw oedema and formalin induced licking were used. The study of the pharmacodynamic comparison of free DMA and products of β-CD:DMA demonstrated no significant difference in the majority of the tests performed. Plasma concentrations of DMA and DMA:β-CD...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Solubility; Dexamethasone acetate; Β-cyclodextrin; Bioavailability; Anti-inflammatory activity.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132014000600887

Bioavailability of the sodium pertechnetate and morphometry of organs isolated from rats: study of possible pharmacokinetic interactions of a ginkgo biloba extract
Provedor de dados: 52
Autores: Moreno,Silvana Ramos Farias; Carvalho,Jorge José; Nascimento,Ana Lúcia; Pereira,Mário; Rocha,Emely Kazan; Diré,Gláucio; Arnobio,Adriano; Caldas,Luiz Querino de Araújo; Bernardo-Filho,Mario.
Many compounds affect the bioavailability of radiobiocomplexes as radiopharmaceuticals. Ginkgo Biloba extract (EGb) has several effects. The influence of an EGb on the bioavailability of the radiobiocomplex sodium pertechnetate (Na99mTcO4) and on the morphometry of the organs was evaluated. Rats were treated with EGb and Na99mTcO4 was injected. The animals were sacrificed; the radioactivity in the organs was counted. The results showed that EGb altered the Na99mTcO4 bioavailability in the kidneys, liver and duodenum. Morphometric analysis of the organs showed significant alterations (P&lt;0.05), probably caused by metabolites generated by EGb and capable of altering the bioavailability of the Na99mTcO4.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Ginkgo biloba extract; Bioavailability; Radiobiocomplex; Sodium pertechnetate; Morphometry.
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132005000700011

Drug interaction with radiopharmaceuticals: effect on the labeling of red blood cells with technetium-99m and on the bioavailability of radiopharmaceuticals
Provedor de dados: 52
Autores: Gomes,Maria Luisa; Oliveira,Marcia B. Nunes de; Bernardo-Filho,Mario.
The evidence that natural and synthetic drugs can affect radiolabeling or bioavailability of radiopharmaceuticals in setting of nuclear medicine clinic is already known. However, this drug interaction with radiopharmaceuticals (DIR) is not completely understood. Several authors have described the effect of drugs on the labeling of blood elements with technetium-99m (99mTc) and on the biodistribution of radiopharmaceuticals. When the DIR is known, if desirable or undesirable, the natural consequence is a correct diagnosis. However, when it is unknown, it is undesirable and the consequences are the possibility of misdiagnosis and/or the repetition of the examination with an increase of radiation dose to the patient. The possible explanation to the appearance...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Drug interaction; Blood elements; Radiopharmaceuticals; Bioavailability.
Ano: 2002
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132002000500020

Combined application of bio-organic phosphate and phosphorus solubilizing bacteria (Bacillus strain MWT 14) improve the performance of bread wheat with low fertilizer input under an arid climate
Provedor de dados: 58
Autores: Tahir,Muhammad; Khalid,Umaira; Ijaz,Muhammad; Shah,Ghulam Mustafa; Naeem,Muhammad Asif; Shahid,Muhammad; Mahmood,Khalid; Ahmad,Naveed; Kareem,Fazal.
Abstract This study was aimed to investigate the effect of bio-organic phosphate either alone or in combination with phosphorus solubilizing bacteria strain (Bacillus MWT-14) on the growth and productivity of two wheat cultivars (Galaxy-2013 and Punjab-2011) along with recommended (150–100 NP kg ha−1) and half dose (75–50 NP kg ha−1) of fertilizers. The combined application of bio-organic phosphate and the phosphorous solubilizing bacteria strain at either fertilizer level significantly improved the growth, yield parameters and productivity of both wheat cultivars compared to non-inoculated control treatments. The cultivar Punjab-2011 produced the higher chlorophyll contents, crop growth rate, and the straw yield at half dose of NP fertilizer; while...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Phosphorous; Phosphorous solubilizing bacteria; Bioavailability; Rhizosphere; Low fertilizer input.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822018000500015

A nanoemulsion-based delivery system for imatinib and in vitro anticancer efficacy
Provedor de dados: 60
Autores: Karimi,Maryam; Karimian,Khashayar; Heli,Hossein.
A self-nanoemulsifying drug delivery system (SNEDDS) composed of ethyl oleate, Tween 80 and polyethylene glycol 600 was prepared as a new route to improve the efficacy of imatinib. The drug-loaded SNEDDS formed nanodroplets of ethyl oleate stabilized by Tween 80 and polyethylene glycol 600 with a diameter of 81.0±9.5 nm. The nanoemulsion-based delivery system was stable for at least two months, with entrapment efficiency and loading capacity of 16.4±0.1 and 48.3±0.2%, respectively. Imatinib-loaded SNEDDS was evaluated for the drug release profiles, and its effectiveness against MCF-7 cell line was investigated. IC50 values for the imatinib-loaded SNEDDS and an imatinib aqueous solution were 3.1 and 6.5 µg mL-1, respectively.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Glivec; Nanoemulsion; Anticancer drug; Bioavailability; Breast cancer cell.
Ano: 2020
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100640

The Liquisolid technique: an overview
Provedor de dados: 60
Autores: Burra,Shashidher; Yamsani,Madhusudhanrao; Vobalaboina,Venkateswarlu.
A novel "Powder Solution Technology" involves absorption and adsorption efficiency which makes use of liquid medications, drug suspensions admixed with suitable carriers, coating materials and formulated into free flowing, dry looking, non adherent and compressible powder forms. Based upon a new mathematical model expression, improved flow characteristics and hardness of the formulation has been achieved by changing the proportion of Avicel ® PH 200 and Aerosil ® PH 200 from 50:1 ratio to 5:1 and in which the drug is dispersed in an almost molecularly state. Due to their significantly improved wetting properties a greater drug surface area is exposed to the dissolution media, resulting in an increased dissolution rate and bio availability. By using the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Liquisolid; Solubility; Bioavailability; Flow properties; Load factor; Powder solution technology.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502011000300005

Development of self-nanoemulsifying tablet (SNET) for bioavailability enhancement of sertraline
Provedor de dados: 60
Autores: Rahman,Mohammad Akhlaquer; Mujahid,Mohammad.
Abstract The purpose of the study was to combine the advantages of self-nanoemulsifying drug delivery systems and tablets as a conventional dosage form. Self-nanoemulsifying drug delivery system (SNEDDS) was prepared to enhance the solubility and thus oral bioavailability of sertraline. Aqueous titration method was used to prepare the liquid SNEDDS; ternary phase diagrams were constructed and based on smaller droplet size (24.8 nm), minimum viscosity (153.63 cP) and polydispersity index (0.182), higher percentage transmittance (95%) and in vitro drug release (97%), an optimum system was designated. Liquid SNEDDS was transformed into free-flowing powder by solid adsorption technique followed by compression into tablets. In vitro release of sertraline from...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: SNEDDS; Phase diagrams; Solubility; Thermodynamic stability; Oral delivery; Bioavailability.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000100620

Dietary intake and health effects of selected toxic elements
Provedor de dados: 61
Autores: Silva,André Luiz Oliveira da; Barrocas,Paulo R.G.; Jacob,Silvana do Couto; Moreira,Josino Costa.
Anthropogenic activities have being contributing to the spread of toxic chemicals into the environment, including several toxic metals and metalloids, increasing the levels of human exposure to many of them. Contaminated food is an important route of human exposure and may represent a serious threat to human health. This mini review covers the health effects caused by toxic metals, especially Cd, Hg, Pb and As, the most relevant toxic elements from a human health point of view.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Bioavailability; Contamination; Heavy metals; Metal toxicity.
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1677-04202005000100007

Nickel adsorption and desorption in an acric oxisol as a function of pH, ionic strength and incubation time
Provedor de dados: 64
Autores: Mellis,Estêvão Vicari; Casagrande,José Carlos; Soares,Marcio Roberto.
ABSTRACT Although nickel (Ni) has both important potential benefits and toxic effects in the environment, its behavior in tropical soils has not been well studied. Nickel adsorption-desorption in topsoil and subsoil samples of an acric Oxisol was studied at three pH values (from 3.0 to 8.0). Adsorption-desorption isotherms were elaborated from experiments with increasing Ni concentration (5 to 100 mg L-1), during 0, 4, and 12 weeks, using CaCl2 0.01 and 0.1 M as electrolytic support in order to also verify the effect of Ni-soil time contact and of ionic strength on the reaction. Experimental results of Ni adsorption fitted Langmuir model, which indicated that maximum Ni adsorption (71,440 mg kg-1) occurred at subsoil, after 12 weeks. Nickel affinity (KL)...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Sorption; Bioavailability; Soil pollution; Heavy metal.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-70542017000100032