Consulta: subjectFacets:"Biodosimetry"
Registros recuperados: 5
Data/hora: 05/06/2024 01:26:36

Dose assessment by quantification of chromosome aberrations and micronuclei in peripheral blood lymphocytes from patients exposed to gamma radiation
Provedor de dados: 74
Autores: Silva-Barbosa,Isvânia; Pereira-Magnata,Símey; Amaral,Ademir; Sotero,Graça; Melo,Homero Cavalcanti.
Scoring of unstable chromosome aberrations (dicentrics, rings and fragments) and micronuclei in circulating lymphocytes are the most extensively studied biological means for estimating individual exposure to ionizing radiation (IR), which can be used as complementary methods to physical dosimetry or when the latter cannot be performed. In this work, the quantification of the frequencies of chromosome aberrations and micronuclei were carried out based on cytogenetic analyses of peripheral blood samples from 5 patients with cervical uterine cancer following radiotherapy in order to evaluate the absorbed dose as a result of partial-body exposure to 60Co source. Blood samples were collected from each patient in three phases of the treatment: before...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Chromosome aberrations; Micronuclei; Biodosimetry; Partial-body irradiation; Lymphocyte.
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572005000300021

Physical and biological dosimetry for risk perception in radioprotection
Provedor de dados: 52
Autores: Amaral,Ademir.
The increase in ionizing radiation (IR) applications, especially nuclear, has been followed by the growth of public concern for the potential associated risks. The public’s perception of such risks is often based on the philosophy that IR is harmful at any exposure level. On the other hand, although radiation workers have knowledge about the nature of IR and its potential health effects, the relationship between absorbed dose and risk is not well understood, principally for low doses. This report presents an overview of physical and biological dosimetry as complementary methodologies, as well as their possible contribution for improving risk perception in radioprotection.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Biodosimetry; Physical Dosimetry; Radioprotection; Public perception.
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132005000700034

Trends in biological dosimetry: an overview
Provedor de dados: 52
Autores: Amaral,Ademir.
Biological dosimetry (biodosimetry) is based on investigations of induced biological effects (biomarkers) in order to correlate them with radiation dose. Among the indicators employed in biodosimetry, scoring of chromosome aberrations is the most reliable method to quantify individual exposure to ionizing radiation. The technique, applied to circulating lymphocytes, has been developed into a routine procedure to evaluate the dose in the case of real or suspected accidental exposure. Considering the radiosensitivity of lymphocytes in vitro and in vivo as being the same, the dose effect relationship obtained after in vitro irradiation of blood has been widely used, with medico-legal value, for evaluating individual radiation exposure. This report presents an...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Biodosimetry; Physical dosimetry; Biomarkers; Chromosome aberrations.
Ano: 2002
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132002000500017

Bioindicators in radiation protection
Provedor de dados: 52
Autores: Amaral,Ademir; Fernandes,Thiago Salazar; Cavalcanti,Mariana Brayner.
Biodosimetry is the evaluation of absorbed dose using bioindicators. Among chromosomal aberrations, scoring of dicentrics from peripheral human blood has been used as gold standard for biodosimetry, although in case of large scale incidents its use presents some drawbacks. Advances in technology have led to new investigations allowing or permitting the use of new methods which not only improve this "classical" biodosimetry but permits the design of other bioindicators making possible faster analyses, particularly in events where many persons may have been exposed. This report presents an overview of some recent studies developed by the "Grupo de Estudos em Radioproteção e Radioecologia - GERAR", Nuclear Energy Department of UFPE - Brazil, involving...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Biodosimetry; Physical Dosimetry; Radioprotection; Bioindicators; Protein expression.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132008000700015

Biodosimetry for dose assessment of partial-body exposure: a methodological improvement
Provedor de dados: 52
Autores: Fernandes,Thiago Salazar; Loyd,David C.; Amaral,Ademir.
This study has explored the possibility of combining culture times with extending the duration for which Colcemid is present in cell culture in order to obtain better dose estimations following partial-body exposures. Irradiated and unirradiated blood was mixed to simulate a partial-exposure. Dicentric frequencies and resultant dose estimations were compared from 48 and 72 h cultures with Colcemid added at the beginning, after 24 h or for the final 3 h. The frequencies of dicentrics in first division cells increased with the cell culture time, providing better dose estimations. Unwanted excessive contraction of chromosomes caused by prolonged contact with Colcemid was measured and ways to avoid this are discussed. It is suggested that the combination of a...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Biodosimetry; Partial-body exposure; Dicentrics; Chromosome contraction.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132008000700016