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Antibacterial activity of different types of snake venom from the Viperidae family against Staphylococcus aureus
Provedor de dados: 3
Autores: Canhas, Isabela Nascimento; Heneine, Luiz Guilherme Dias; Fraga, Thaís; Assis, Débora Cristina Sampaio de; Borges, Márcia Helena; Chartone-Souza, Edmar; Nascimento, Andréa Maria Amaral.
Toxins and venoms produced by living organisms have exhibited a variety of biological activities against microorganisms. In this study, we tested seven snake venoms from the family Viperidae for antibacterial activity and the activities of reversal of antibiotic resistance and inhibition of biofilm formation against 22 clinical isolates of Staphylococcus aureus. Bothrops moojeni venom exhibited anti staphylococcal activity with the lowest mean value of minimum inhibitory concentration (MIC). Moreover, reversal of antibiotic resistance was observed for combinations of B. moojeni venom (½ x MIC) and norfloxacin or ampicillin (both ½ x MIC) for 86.4% and 50% of the isolates, respectively. B. moojeni venom alone at ½ MIC inhibited 90% of biofilm formation,...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Bothrops moojeni; Bacteria; Antibiotic-resistance; NorA efflux pump; Biofilm.
Ano: 2017
URL: http://periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/33826