Consulta: subjectFacets:"Bovine herpesvirus-1.2a"
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Data/hora: 10/06/2024 04:49:55

Serological responses in sheep injected with plasmids encoding bovine herpesvirus 1 (BHV-1) gD glycoprotein
Provedor de dados: 45
Autores: Cândido,A.L.; Resende,M.; Bessa,L.R.G.; Leite,R.C.
A genetic vaccine consisting of the bovine herpesvirus-1.2a (BHV-1.2a) glycoprotein D (gD) gene under the control of the cytomegalovirus immediate-early promoter/enhancer was generated and administered to sheep intramuscularly in the neck. All animals developed serum antibodies which recognized the homologous antigen (BHV-1.2a strain BH-83) and also exhibited cross-reactivity against the heterologous antigen (BHV-5 strain EVI-190). Three intramuscularly injections were given but serological responses were not improved after the second inoculation. Specific antibodies were detected against BHV-1.2a until at least 12 months after the first inoculation. However, the capacity to induce antibodies against BHV-5 was lower and of shorter duration than to BHV-1.2a.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Bovine herpesvirus-1.2a; Glycoprotein D gene; DNA vaccine; ELISA.
Ano: 2003
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352003000300002