Consulta: subjectFacets:"CCR5 co-receptor"
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CCR5 genotypes and progression to HIV disease in perinatally infected children
Provedor de dados: 55
Autores: Angelis,Daniela Souza Araújo de; Freire,Wilton Santos; Pannuti,Cláudio Sergio; Succi,Regina Célia de Menezes; Machado,Daisy Maria.
The CCR5 molecule, a chemokine receptor, is the most important co-receptor for macrophage-tropic HIV-1. A 32-bp deletion in the gene encoding CCR5 (CCR5-del32) confers nearly complete resistance to HIV-1 infection in homozygotes, and slows the rate of progression to AIDS in heterozygous adults. The aim of this study was to describe the CCR5 genotypes and the characteristics of HIV disease progression in perinatally infected children. From a total of 51 children analyzed for the CCR5-del32 mutation, 18 (35%) were considered to be rapid progressors, 28 (55%) were moderate progressors and 5 (10%) were slow progressors. A portion of the CCR5 gene was amplified by PCR from genomic DNA followed by agarose gel electrophoresis. Forty-nine children (96%) carried...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV-1; CCR5 co-receptor; HIV disease progression; Perinatally infected children.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000200004