Consulta: subjectFacets:"COX-2"
Registros recuperados: 7
Data/hora: 09/06/2024 17:13:59

Protective Role of Melatonin in Mouse Spermatogenesis Induced by Sodium Arsenite
Provedor de dados: 77
Autores: Bustos-Obregón,Eduardo; Poblete,Daniel; Catriao,Roberto; Fernandes,Fábio Henrique.
Arsenic is a testicular environmental toxic. Melatonin (Me), being a potent antioxidant, may reduce the damage caused by arsenic in male fertility. The effects of daily oral exposure of Sodium Arsenite (As; 7.0 mg/kg/bw); Melatonin (Me, 10.0 mg/kg/bw); Me (10.0 mg/kg/bw) plus As (7.0 mg/kg/bw), and Negative Control (NaCl 0.9%) in male CF-1 adult mice were assessed in acute (8.3 days), chronic (33.2 days) and recovery (66,4 days) of testicular damage. We evaluated changes in testicular weight and histopathological, morphometric measurements, expression of COX-2 and Androgen Receptor (AR) antigens and lipid peroxidation levels. Treatment resulted in decreased tubular diameter and AR expression, and increased: interstitial area, luminal diameter, COX-2...
Tipo: Journal article
Palavras-chave: Mouse; Arsenic; COX-2; Androgen receptor; Oxidative stress; Melatonin.
Ano: 2013
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022013000300012

Uso del piroxicam como tratamiento adjunto en carcinoma de células escamosas en el tercer párpado de un caballo
Provedor de dados: 108
Autores: Iwabe,Simone; Ramírez-López,León; Juárez-Sánchez,Mónica.
El objetivo del presente trabajo fue evaluar el uso del piroxicam como tratamiento adjunto en un caso de carcinoma de células escamosas en un caballo. En septiembre de 2007, un caballo, macho castrado, raza Pura Sangre Inglés, de diez años de edad y 555 kg de peso fue referido a un oftalmólogo privado por presentar secreción mucoide abundante, hiperemia conjuntival y tejido granulomatoso en el tercer párpado del ojo izquierdo. Se inició tratamiento médico con antibiótico y antiinflamatorio, y se tomó biopsia del tejido granulomatoso presente en el tercer párpado. El resultado fue hiperplasia epitelial no tumoral. En una nueva evaluación (después de diez días), se observó ligera disminución del tejido. Después de dos semanas de tratamiento, sin mejoría se...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Carcinoma de células escamosas; Caballo; Tercer párpado; AINES; COX-2; Tumor.
Ano: 2009
URL: http://www.scielo.org.mx/scielo.php?script=sci_arttext&pid=S0301-50922009000400005

Carcinoma de células escamosas multicêntrico, com apresentação “in situ”, associado à formação de cistos epidérmicos em um cão
Provedor de dados: 195
Autores: Horta, Rodrigo dos Santos; Lavalle, Gleidice Eunice; Costa, Mariana de Pádua; Paes, Paulo Ricardo de Oliveira; de Araújo, Roberto Baracat.
O carcinoma de células escamosas “in situ”, citomorfologicamente maligno, apresenta-se restrito ao epitélio, sem invasão da membrana basal, sendo classificado como uma lesão pré-maligna, passível de progressão e metástase se o tratamento não for instituído. A apresentação multicêntrica, normalmente encontra-se relacionada à exposição a radiação ultravioleta e desenvolvimento inicial de dermatite actínica, no entanto, raramente pode desenvolver-se independentemente da exposição solar, em localização variável, sendo denominada Doença de Bowen. O presente trabalho relata o desenvolvimento do carcinoma de células escamosas em múltiplos sítios, associado à áreas de formação de cisto epidérmico em uma cadela, não castrada, com oito anos de idade, da raça...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Carcinoma espinocelular; Doença de Bowen; COX-2.
Ano: 2013
URL: http://www.revistamvez-crmvsp.com.br/index.php/recmvz/article/view/21425

Tubulopapillary rectal adenocarcinoma in dog: clinical, surgical, pathological and immunophenotypical aspects: case report
Provedor de dados: 45
Autores: Oliveira,A.R.; Flecher,M.C.; Horta,R.S.; Souza,M.C.C.; Hardt,I.; Gonçalves,A.B.B.; Cassali,G.D.; Souza,T.D.
ABSTRACT Intestinal carcinomas are rare in dogs. The prognosis and survival time are dependent of the histological type, the invasion of the intestinal wall by the malignant cells and the ability of primary neoplasm to produce metastasis. This study reports a case of a Yorkshire dog that developed a rectal tubulopapillary adenocarcinoma progressing to a peritoneal carcinomatosis and multiple metastasis in large intestines, bladder, kidney, iliac lymph node, liver and lungs, six months after transanal surgical resection of the primary rectal neoplasm. Clinical, surgical, pathological and immunophenotypic findings are described. COX-2 imunohistochemical score was higher in hepatic metastasis (score 9) than in the primary tumour (score 6), and the growth...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Enteric neoplasm; COX-2; Oncology; Carcinomatosis; Metastasis.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352018000200463

Cyclooxygenase-2 and hypoxia-regulated proteins are modulated by basic fibroblast growth factor in acute renal failure
Provedor de dados: 48
Autores: Villanueva,Sandra; Escobar,Pía; Jacubovsky,Ioram; Irarrázabal,Carlos; Carreño,Juan E; Erpel,José M; Céspedes,Carlos; González,Alexis A; Vio,Carlos P; Velarde,Victoria.
Acute renal failure (ARF) can be caused by injuries that induce tissue hypoxia, which in turn can trigger adaptive or inflammatory responses. We previously showed the participation of basic fibroblast growth factor (FGF-2) in renal repair. Based on this, the aim of this study was to analyze the effect of FGF-2 signaling pathway manipulation at hypoxia-induced protein levels, as well as in key proteins from the vasoactive systems of the kidney. We injected rat kidneys with FGF-2 recombinant protein (r-FGF) or FGF-2 receptor antisense oligonucleotide (FGFR2-ASO) after bilateral ischemia, and evaluated the presence of iNOS, EPO and HO-1, in representation of hypoxia-induced proteins, as well as COX-2, renin, kallikrein, and B2KR, in representation of the...
Tipo: Journal article
Palavras-chave: ARF; COX-2; FGF-2; Kidney regeneration.
Ano: 2012
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602012000100007

The effects of low level laser therapy on injured skeletal muscle
Provedor de dados: 52
Autores: Renno,Ana Claudia Muniz; Assis,Lívia; Peres,Beatriz; Rodrigues,Natalia Camargo; Brunelli,Roberta de Matos; Toma,Renata Luri; Medalha,Carla Christina; Ribeiro,Daniel Araki.
The main purpose of the present study was to investigate the effects of low-level laser therapy (LLLT) used in two different fluencies on injured skeletal muscle after cryolesion by means of histopathological analysis and immunohistochemistry for COX-2. A total of sixty male Wistar rats were randomly distributed into three groups: injured animals without any treatment; 808 nm laser treated group, at 10 J/cm² and 808 nm laser treated group, at 50 J/cm². Each group was divided into two different subgroups (n=10) on days 6 and 13 post-injury. The results showed that the animals irradiated with laser at 10 J/cm² or 50 J/cm² presented the areas with cell infiltrate and pointed out to minor and mild areas with destroyed zones compared with the control group....
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Low level laser therapy; Rat; Muscle repair; COX-2.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132014000100008

Modulation of the prostaglandin-endoperoxide synthase 2 gene expression by variant haplotypes: influence of the 3′-untranslated region
Provedor de dados: 56
Autores: Piranda,D.N.; Abreu,R.B.V.; Freitas-Alves,D.R.; de Carvalho,M.A.; Vianna-Jorge,R.
The inducible inflammatory enzyme cycloxigenase-2 is up-regulated in cancer, and favors tumor progression. Cycloxigenase-2 is encoded by the prostaglandin-endoperoxide synthase 2 (PTGS2) gene, which presents sequence variations in the promoter region (PR) and in the 3′-untranslated region (3′-UTR). Different PR (rs689465, rs689466, rs20417) and 3′-UTR (rs5275) variants were generated by site-directed mutagenesis, and combined in haplotypes to access expression levels using a reporter system (luciferase) in human cells (MCF-7 and HEK293FT). Luciferase activity did not differ significantly among PTGS2 PR constructs, except for pAAC (containing variant allele rs20417 C), with 40% less activity than pAAG (wild-type sequence) in MCF-7 cells (P&lt;0.01). Despite...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: COX-2; PTGS2; Haplotypes; Gene expression; MCF-7; HEK293FT.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018000200602