Consulta: subjectFacets:"Caged compounds"
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Data/hora: 07/06/2024 17:13:05

In vivo photorelease of GABA in the mouse cortex
Provedor de dados: Brazilian Journal of Medical and Biological Research
Autores: Lopes-dos-Santos,V.; Campi,J.; Filevich,O.; Ribeiro,S.; Etchenique,R.
Electrical stimulation has been used for more than 100 years in neuroscientific and biomedical research as a powerful tool for controlled perturbations of neural activity. Despite quickly driving neuronal activity, this technique presents some important limitations, such as the impossibility to activate or deactivate specific neuronal populations within a single stimulation site. This problem can be avoided by pharmacological methods based on the administration of receptor ligands able to cause specific changes in neuronal activity. However, intracerebral injections of neuroactive molecules inherently confound the dynamics of drug diffusion with receptor activation. Caged compounds have been proposed to circumvent this problem, for spatially and temporally...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Caged compounds; Neural stimulation; GABA; Cerebral cortex; Photorelease.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011000700012