Consulta: subjectFacets:"Cerebral malaria"
Registros recuperados: 2
Data/hora: 12/06/2024 15:38:44

Modulation of cerebral malaria by curcumin as an adjunctive therapy
Provedor de dados: Brazilian Journal of Infectious Diseases
Autores: Jain,Kunal; Sood,Sumeet; Gowthamarajan,K.
Cerebral malaria is the most severe and rapidly fatal neurological complication of Plasmodium falciparum infection and responsible for more than two million deaths annually. The current therapy is inadequate in terms of reducing mortality or post-treatment symptoms such as neurological and cognitive deficits. The pathophysiology of cerebral malaria is quite complex and offers a variety of targets which remain to be exploited for better therapeutic outcome. The present review discusses on the pathophysiology of cerebral malaria with particular emphasis on scope and promises of curcumin as an adjunctive therapy to improve survival and overcome neurological deficits.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Cerebral malaria; Curcumin; Adjunctive; Cognitive deficit.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000500011

Increased levels of glutamate in the central nervous system are associated with behavioral symptoms in experimental malaria
Provedor de dados: Brazilian Journal of Medical and Biological Research
Autores: Miranda,A.S.; Vieira,L.B.; Lacerda-Queiroz,N.; Souza,A.H.; Rodrigues,D.H.; Vilela,M.C.; Gomez,M.V.; Machado,F.S.; Rachid,M.A.; Teixeira,A.L.
Cerebral malaria (CM) is a severe complication resulting from Plasmodium falciparum infection. This condition has been associated with cognitive, behavioral and motor dysfunctions, seizures and coma. The underlying mechanisms of CM are incompletely understood. Glutamate and other metabolites such as lactate have been implicated in its pathogenesis. In the present study, we investigated the involvement of glutamate in the behavioral symptoms of CM. Seventeen female C57BL/6 mice (20-25 g) aged 6-8 weeks were infected with P. berghei ANKA by the intraperitoneal route using a standardized inoculation of 10(6) parasitized red blood cells suspended in 0.2 mL PBS. Control animals (N = 17) received the same volume of PBS. Behavioral and neurological symptoms were...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Cerebral malaria; Glutamate; Cerebrospinal fluid; Behavioral changes; SHIRPA.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010001200006