Consulta: subjectFacets:"Chagas disease"
Registros recuperados: 29
Data/hora: 08/06/2024 02:33:53

Phylogenetic incongruence inferred with two mitochondrial genes in Mepraia spp. and Triatoma eratyrusiformis (Hemiptera, Reduviidae)
Provedor de dados: 74
Autores: Campos-Soto,Ricardo; Torres-Pérez,Fernando; Solari,Aldo.
Mitochondrial DNA (mtDNA) is widely used to clarify phylogenetic relationships among and within species, and to determine population structure. Due to the linked nature of mtDNA genes it is expected that different genes will show similar results. Phylogenetic incongruence using mtDNA genes may result from processes such as heteroplasmy, nuclear integration of mitochondrial genes, polymerase errors, contamination, and recombination. In this study we used sequences from two mitochondrial genes (cytochrome b and cytochrome oxidase subunit I) from the wild vectors of Chagas disease, Triatoma eratyrusiformis and Mepraia species to test for topological congruence. The results showed some cases of phylogenetic incongruence due to misplacement of four haplotypes...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Heteroplasmy; Sylvatic vectors; Chagas disease; Gajardoi; Spinolai; Cytochrome.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572015000300390

Canine trypanosomiasis: etiology of infection and implications for public health
Provedor de dados: 80
Autores: Eloy,LJ; Lucheis,SB.
Canine trypanosomiasis, caused by protozoans of the genus Trypanosoma, is divided into two primary types: the American form (Chagas disease), due to Trypanosoma cruzi infection, and the African form (sleeping sickness or surra), provoked by Trypanosomaevansi. This disease was originally enzootic and affected only wild animals, including mammals and birds, which served as reservoirs. Later, it spread to domestic animals such as horses, cattle and dogs. The disease became a zoonosis when contact between rural inhabitants and natural Trypanosoma foci occurred, due to ecological imbalances and increasing migration. Dogs are significantly involved in this context, because they are the main domestic animals and participate in the transmission and maintenance...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Canine trypanosomiasis; Trypanosoma cruzi; Trypanosoma evansi; Chagas disease; Surra.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992009000400002

Using prodigiosin against some gram-positive and gram-negative bacteria and Trypanosoma cruzi
Provedor de dados: 80
Autores: Herráez,Rocío; Mur,Anna; Merlos,Alexandra; Viñas,Miguel; Vinuesa,Teresa.
Abstract  Background: This work aimed to explore the action of natural prodigiosin on both bacterial organisms and Trypanosoma cruzi cells.  Methods: Natural prodigiosin pigment was extracted and purified from cultures of Serratia marcescens. Two media, peanut broth and peptone glycerol broth, both recommended in the literature for prodigiosin production, were compared. The prodigiosin obtained was employed to explore its antimicrobial properties against both bacteria and Trypanosoma cruzi cells.  Results: Peanut broth yielded four times more prodigiosin. The prodigiosin showed remarkable activity (minimal inhibitory concentrations in the range of 2-8 µM for bacteria and half maximal inhibitory concentration of 0.6 µM for Trypanosoma cruzi). In fact, the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Trypanosoma cruzi; Chagas disease; Prodigiosin; Atomic force microscopy.
Ano: 2019
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992019000100314

Benznidazole affects expression of Th1, Th17 and Treg cytokines during acute experimental Trypanosoma cruzi infection
Provedor de dados: 80
Autores: Gatto,Mariana; Oliveira,Larissa Ragozo Cardoso; Dias,Fernanda De Nuzzi; Araújo Júnior,João Pessoa; Lima,Carlos Roberto Gonçalves; Lordelo,Eliana Peresi; Santos,Rodrigo Mattos dos; Kurokawa,Cilmery Suemi.
Abstract  Background The present study evaluated the effect of treatment with benznidazole on mRNA expression of IFN-γ, IL-17, IL-10, TGF-β and FoxP3 in spleen and heart tissue of BALB/c mice in the acute phase of an experimental infection with Trypanosoma cruzi, strains JLP or Y.  Methods The mRNA expression of cytokines and parasite load were assessed by q-PCR. Dependent groups were compared using Student's paired t-test and independent groups were compared using Student's unpaired t-test.  Results Infection with the JLP or Y strains increased expression of IFN-γ in the heart and of IL-10 and IL-17 in the spleen and heart compared to uninfected animals. Treatment increased the expression of IFN-γ and decreased the expression of IL-17, IL-10, TGF- β and...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Chagas disease; Trypanosoma cruzi; Immune response; Cytokines; Q-PCR.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992017000100320

Description and ontogenetic morphometrics of nymphs of Belminus herreri Lent &amp;amp; Wygodzinsky (Hemiptera: Reduviidae, Triatominae)
Provedor de dados: 82
Autores: Rocha,Dayse da S.; Patterson,James S.; Sandoval,Claudia M.; Jurberg,José; Ângulo,Victor M.; Esteban A.,Lyda; Galvão,Cleber.
For the first time all instars of a species of the genus Belminus are described based on laboratory F1 generation specimens from adults caught in department of Cesar, Colombia. Ontogenetic morphometrics of postembryonic head development was made, suggesting that the greatest changes occur between the 1st and 2nd instars.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Chagas disease; Vector; Bolboderini; Systematics.
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1519-566X2005000300019

Riesgo de transmisión de Trypanosoma cruzi en el municipio de Metztitlán, estado de Hidalgo, México, mediante la caracterización de unidades domiciliares y sus índices entomológicos
Provedor de dados: 82
Autores: Becerril,Marco A; Angeles-Pérez,Vidal; Noguez-García,Julio Cr; Imbert-Palafox,José L.
In order to determine the risk of transmission of Trypanosoma cruzi by triatomines in Metztitlan municipality, Hidalgo State, Mexico, entomological indexes were calculated and the characteristics of dwellings were described. A transversal, retrospective, descriptive, and observational study was performed by means of an intentional not probabilistic and expertise sampling from January to December of 2005 in 10 localities in which presence of triatomines were investigated either intra or peridomestic environmental in 699 houses. Building material and presence of infected triatomines with T. cruzi were registered to determine entomologic indexes. The triatomine species collected were: Triatoma barberi (Usinger) and T. mexicana (Herrich-Schaeffer) (Hemiptera:...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Triatoma barberi; Triatoma mexicana; Chagas disease; Vector; Epidemiology.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1519-566X2010000500021

Indicadores de infestación, colonización e infección de Triatoma dimidiata (Latreille) (Hemiptera: Reduviidae) en Campeche, México
Provedor de dados: 82
Autores: Hernández,Jorge L; Rebollar-Téllez,Eduardo A; Infante,Francisco; Morón,Alejandro; Castillo,Alfredo.
Triatoma dimidiata (Latreille) is considered to be one of the primary vectors of Chagas disease in Southern Mexico and Central America. The objective of the present study was to obtain ecological information on T. dimidiata in two rural communities of Campeche, Mexico, where the vector is poorly studied. Our work consisted of monthly samplings carried out during one-year time at three levels: sylvatic, peridomestic and intradomestic, in order to estimate the population abundance of this species and its rate of infection with Trypanosoma cruzi. Triatoma dimidiata was the unique vector of this disease collected in San Juan Bautista Sakcabchen (SJBS) and Crucero San Luis (CSL). The total of 145 individuals were captured in SJBS; from these, 26.9%, 20% and...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Chagas disease; Triatominae; Entomological index; Population abundance.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1519-566X2010000600027

Behavioral evidence of an ectoparasitic interaction between Triatoma pseudomaculata Corrêa e Espínola (Heteroptera: Reduviidae) and Periplaneta americana (L.) (Blattodea: Blattidae)
Provedor de dados: 82
Autores: Pontes,GB; Noireau,F; Lorenzo,MG.
The present work tested whether Triatoma pseudomaculata Corrêa &amp;amp; Espínola shows behavioral traits indicating that it is capable of feeding on arthropods. We consistently observed nymphs extending their proboscis in the direction of cockroaches and attempting to bite. Insects presented a preference for biting specific cockroach body parts. Our results suggest that arthropod hemolymph represents an alternative source of food that increases the survival of T. pseudomaculata individuals undergoing long starvation.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Behavior; Chagas disease; Cockroach; Triatomine.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1519-566X2011000600013

Protocol optimization for the detection of Trypanosoma cruzi DNA in açai (Euterpe oleraceae) pulp
Provedor de dados: 36
Autores: CARDOSO,Gabrielle Virgínia Ferreira; OLIVEIRA,Andrey Carlos do Sacramento de; SILVA,Andréia Silva da; SILVA,Marcos Clécio de Lemos; LIMA,Joelson Sousa; ROOS,Talita Bandeira; MORAES,Carina Martins de.
ABSTRACT Chagas disease, caused by the protozoan Trypanosoma cruzi, has often been linked to oral transmission through açai consumption. Molecular methods that allow fast and accurate identification of the pathogen are important for the detection of the presence of the parasite in this food. This study aimed to optimize polymerase chain reaction (PCR)-based detection of T. cruzi DNA in açai pulp. Several dilutions of T. cruzi DTU TcI trypomastigote forms were cultured in liver infusion tryptose (LIT) medium. Trypanosoma cruzi DNA was extracted from the cells and subjected to PCR. Subsequently, culture dilutions were added to açai pulp to evaluate the detection threshold of the optimized PCR assay. We demonstrate that our assay can detect T. cruzi DNA in...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Detection method; Foodborne disease; Food pathogen; Molecular detection; Chagas disease.
Ano: 2021
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0044-59672021000100079

Molecular research and the control of Chagas disease vectors
Provedor de dados: 42
Autores: Abad-Franch,Fernando; Monteiro,Fernando A.
Chagas disease control initiatives are yielding promising results. Molecular research has helped successful programs by identifying and characterizing introduced vector populations and by defining intervention targets accurately. However, researchers and health officials are facing new challenges throughout Latin America. Native vectors persistently reinfest insecticide-treated households, and sylvatic triatomines maintain disease transmission in humid forest regions (including Amazonia) without colonizing human dwellings. In these scenarios, fine-scale vector studies are essential to define epidemiological risk patterns and clarify the involvement of little-known triatomine taxa in disease transmission. These eco-epidemiological investigations, as well as...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Molecular systematics; DNA; Allozymes; Triatominae; Chagas disease.
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652005000300007

The pentose phosphate pathway in Trypanosoma cruzi: a potential target for the chemotherapy of Chagas disease
Provedor de dados: 42
Autores: Igoillo-Esteve,Mariana; Maugeri,Dante; Stern,Ana L.; Beluardi,Paula; Cazzulo,Juan J.
Trypanosoma cruzi is highly sensitive to oxidative stress caused by reactive oxygen species. Trypanothione, the parasite's major protection against oxidative stress, is kept reduced by trypanothione reductase, using NADPH; the major source of the reduced coenzyme seems to be the pentose phosphate pathway. Its seven enzymes are present in the four major stages in the parasite's biological cycle; we have cloned and expressed them in Escherichia coli as active proteins. Glucose 6-phosphate dehydrogenase, which controls glucose flux through the pathway by its response to the NADP/NADPH ratio, is encoded by a number of genes per haploid genome, and is induced up to 46-fold by hydrogen peroxide in metacyclic trypomastigotes. The genes encoding...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Trypanosoma cruzi; Chagas disease; Pentose phosphate pathway; Oxidative stress; NADPH generation.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652007000400007

Some considerations about the ecology of Triatominae
Provedor de dados: 42
Autores: Noireau,François; Carbajal-de-la-Fuente,Ana L.; Lopes,Catarina M.; Diotaiuti,Lileia.
Observations on the ecology of silvatic Triatominae are still fragmentary, principally because target species in control process are almost exclusively domestic. Report of silvatic species invading human dwellings must lead research to be focused on their original ecology, in order to assist in understanding their process of domestication and devising strategies for surveillance.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Chagas disease; Triatominae; Silvatic environment; Ecology.
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652005000300006

Neuronal changes caused by Trypanosoma cruzi: an experimental model
Provedor de dados: 42
Autores: Moreira,Neide M; Sant'ana,Débora M. G; Araújo,Eduardo J. A; Toledo,Max J. O; Gomes,Mônica L; Araújo,Silvana M. de.
Define an experimental model by evaluating quantitative and morphometric changes in myenteric neurons of the colon of mice infected with Trypanosoma cruzi. Twenty-eight Swiss male mice were distributed into groups: control (CG, n=9) and inoculated with 100 (IG100, n=9) and 1000 (IG1000, n=10) blood trypomastigotes, Y strain-T. cruzi II. Parasitemia was evaluated from 3-25 days post inoculation (dpi) with parasites peak of 7.7 × 10(6) and 8.4 × 10(6) trypomastigotes/mL at 8th dpi (p&amp;gt;0.05) in IG100 and IG1000, respectively. Chronic phase of the infection was obtained with two doses of 100mg/Kg/weight and one dose of 250mg/Kg/weight of Benznidazole on 11, 16 and 18 dpi. Three animals from each group were euthanized at 18, 30 and 75 dpi. The colon was...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Chagas disease; Colon; Enteric nervous system; Giemsa; Trypanosoma cruzi.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652011000200014

Chagas disease in prehistory
Provedor de dados: 42
Autores: Ferreira,Luiz F.; Jansen,Ana M.; Araújo,Adauto.
The classical hypothesis proposes that Chagas disease has been originated in the Andean region among prehistoric people when they started domesticating animals, changing to sedentary habits, and adopting agriculture. These changes in their way of life happened nearly 6,000 years ago. However, paleoparasitological data based on molecular tools showed that Trypanosoma cruzi infection and Chagas disease were commonly found both in South and North American prehistoric populations long before that time, suggesting that Chagas disease may be as old as the human presence in the American continent. The study of the origin and dispersion of Trypanosoma cruzi infection among prehistoric human populations may help in the comprehension of the clinical and...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Ancient DNA; Chagas disease; Mummies; Paleoepideiology; Paleoparasitology; Trypanosoma cruzi.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652011000300022

Correlation between infection rate of triatominies and Chagas Disease in Southwest of Bahia, Brazil: a warning sign?
Provedor de dados: 42
Autores: SILVEIRA,ELIEZER A. DA; RIBEIRO,ISRAEL S.; AMORIM,MIGUEL S.; ROCHA,DALVA V.; COUTINHO,HELDER S.; FREITAS,LEANDRO M. DE; TOMAZI,LAIZE; SILVA,ROBSON A.A. DA.
ABSTRACT Chagas disease, caused by the Trypanosoma cruzi, has a wide distribution in South America, and its main method of control is the elimination of triatomines. It is presented here the geographic distribution and the rate of natural infection by T. cruzi of triatomines collected and evaluated from 2008 to 2013 in southwest of Bahia. Triatomines were captured in the intradomiciliary and peridomiciliary areas of five cities located in the southwest of Bahia state, identified, and analyzed for the presence of trypanosomatids in their feces. During the study period the number of patients suspected for acute Chagas disease was recovered from the Notifiable Diseases Information System (SINAN). 8966 triatomines were captured and identified as belonging to...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Infection; Chagas disease; Trypanosoma cruzi; Vector.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652016000501941

Control of Triatoma infestans (Klug) (Reduviidae: Triatominae) with Beauveria bassiana (Bals.) Vuill.: preliminary assays on formulation and application in the field
Provedor de dados: 44
Autores: Luz,Christian; Silva,Ionizete G.; Magalhães,Bonifácio P.; Cordeiro,Celia M. T.; Tigano,Myrian S.
Beauveria bassiana (Bals.) Vuill., isolate CG 306, was assayed against Triatoma infestans (Klug) using indirect application by contact with a treated filter paper. The fungus was deposited on filter paper by vacuum-filtration of a conidial suspension. Estimates of 50% survival time of insects were between 15 and 21 days at 3x10(6) and 10(7) conidia/cm² of treated support, respectively, without significant difference between concentrations. A concentration of 2.4x10(6) conidia/cm² of CG 306 was necessary to kill 50% of T. infestans third instar nymphs 25 days after inoculation at 25°C and 50% relative humidity, when insects were continuously exposed to conidia. The LC50 was significantly higher (2.0x10(7) conidia/cm²) when insects were exposed for 1 h to...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Insecta; Chagas disease; Biological control; Hyphomycetes.
Ano: 1999
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0301-80591999000100011

Parameters for evaluation of clinical trial in mice infected with Trypanosoma cruzi
Provedor de dados: 45
Autores: Falkowski,G.J.S.; Sandri,P.F.; Tiyo,R.; Aleixo,D.L.; Araújo,S.M.
The effectiveness of clinical parameters in the evaluation of Trypanosoma cruzi infection was analyzed in male Swiss mice at 8 weeks old Animals were divided into HG (healthy) and IG (1400 trypomastigotes, intraperitoneally, Y strain - Trypanosoma cruzi). Quantitative and qualitative parameters were evaluated in non-consecutive days in the period, from 7th-11th and 15th-18th days of infection. There were significant differences (P&lt;0.05) between both groups in both periods regarding water consumption, abdominal circumference and weight. The second group presented differences in amount of excreta, body temperature, move-up and mortality. There was no difference (P&amp;gt;0.05) between the groups in food consumption, exploration of self-cleaning and skin...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Clinical analysis; Chagas disease; Experimental infection; Mice; Trypanosoma cruzi.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352012000600020

Cysteine proteinases of Trypanosoma cruzi: from digestive enzymes to programmed cell death
Provedor de dados: 47
Autores: Kosec,Gregor; Alvarez,Vanina; Cazzulo,Juan J.
Trypanosoma cruzi, the parasite causing Chagas disease, contains a number of proteolytic enzymes. The recent completion of the genome sequence of the T. cruzi CL Brener clone suggests the presence of 70 cysteine peptidases, 40 serine peptidases (none of them from the chymotrypsin family), about 250 metallopeptidases (most leishmanolysin homologues), 25 threonine peptidases, and only two aspartyl peptidases, none of them from the pepsin family. The cysteine peptidases belong to 7 families of Clan CA, 3 families of Clan CD, and one each of Clans CE and CF. In Clan CA, the C1 family is represented by cruzipains 1 and 2, biochemically well characterized, as well as cathepsin B and two other cathepsins. There are a number of homologues to calpains (family C2),...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Trypanosoma cruzi; Chagas disease; Cysteine proteinases; Apoptosis; Autophagy.
Ano: 2006
URL: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0327-95452006000300008

Chagas disease: Present status of pathogenic mechanisms and chemotherapy
Provedor de dados: 48
Autores: Maya,Juan Diego; Orellana,Myriam; Ferreira,Jorge; Kemmerling,Ulrike; López-Muñoz,Rodrigo; Morello,Antonio.
There are approximately 7.8 million people in Latin America, including Chile, who suffer from Chagas disease and another 28 million who are at risk of contracting it. Chagas is caused by the flagellate protozoan Trypanosoma cruzi. It is a chronic disease, where 20%-30% of infected individuals develop severe cardiopathy, with heart failure and potentially fatal arrhythmias. Currently, Chagas disease treatment is more effective in the acute phase, but does not always produce complete parasite eradication during indeterminate and chronic phases. At present, only nifurtimox or benznidazole have been proven to be superior to new drugs being tested. Therefore, it is necessary to find alternative approaches to treatment of chronic Chagas. The current treatment...
Tipo: Journal article
Palavras-chave: Chagas disease; Chemotherapy; Nifurtimox; Trypanosoma cruzi; Prostaglandins.
Ano: 2010
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602010000300009

Trypanosoma cruzi Chagas, 1909: genetic variability of isolates from chronic chagasic patients in the Paraná state, Brazil
Provedor de dados: 52
Autores: Kopp,Rogério Luiz; Miyazaki,Márcia; Thomaz-Soccol,Vanete.
The present work had as objective to verify the genetic diversity among strains of Trypanosoma cruzi isolated in chronic chagasic patients in the Paraná state. Fifty patients with compatible clinical symptoms were selected (cardiopathy, megacolon and/or megaesophagus) and that presented positive serological reaction to T. cruzi. Six strains of the protozoan were isolated in hemoculture and identified by electrophoresis in starch thick gel with aid of 14 isoenzymes (6PGD; G6PD; ME¹; ME²; ICD; PGM; GPI; GOT¹; GOT²; NP¹; NP²; DIA; MPI and FH). The statistical analysis were accomplished by the softwares NTSYs and UPGMA. Eighty-four electromorphs were individualized and four isoenzymes (ICD, GPI, 6PGD, e PGM) showed compatibility for heterozygosis. The phenetic...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Trypanosoma cruzi; Multilocus enzyme electrophoresis; Chagas disease; Epidemiology; Phenetic analysis.
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132005000300009

Clinical and nutritional profile of individuals with chagas disease
Provedor de dados: 55
Autores: Geraix,Juliana; Ardisson,Lidiane Paula; Marcondes-Machado,Jussara; Pereira,Paulo Câmara Marques.
Chagas disease (CD), caused by the protozoan Trypanossoma cruzi, affects approximately 18 million individuals in the Americas, 5 million of which live in Brazil. Most chronic sufferers have either the indeterminate form of the disease, without organic compromise, or the cardiac or digestive forms. Despite the importance of this disease, there is no information on the effect of nutrition on CD evolution. We evaluated the clinical-nutritional profile of individuals with CD treated at the Tropical Diseases Nutrition Out-Patient Clinic of the Botucatu School of Medicine, UNESP. A retrospective cohort study was performed between 2002 and 2006, on 66 patients with serum and parasitological diagnosis of CD. Epidemiological, clinical, nutritional, and biochemical...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Chagas disease; Nutrition; Dyslipidemia.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000400008

Prevalence of Trypanosoma cruzi/HIV coinfection in southern Brazil
Provedor de dados: 55
Autores: Stauffert,Dulce; Silveira,Mariangela Freitas da; Mesenburg,Marília Arndt; Manta,Adriane Brod; Dutra,Alessandra da Silva; Bicca,Guilherme Lucas de Oliveira; Villela,Marcos Marreiro.
Abstract Chagas disease reactivation has been a defining condition for acquired immune deficiency syndrome in Brazil for individuals coinfected with Trypanosoma cruzi and HIV since 2004. Although the first coinfection case was reported in the 1980s, its prevalence has not been firmly established. In order to know coinfection prevalence, a cross-sectional study of 200 HIV patients was performed between January and July 2013 in the city of Pelotas, in southern Rio Grande do Sul, an endemic area for Chagas disease. Ten subjects were found positive for T. cruzi infection by chemiluminescence microparticle immunoassay and indirect immunofluorescence. The survey showed 5% coinfection prevalence among HIV patients (95% CI: 2.0–8.0), which was 3.8 times as high as...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Chagas disease; Trypanosoma cruzi; AIDS.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000200180

Emerging acute Chagas Disease in Amazonian Brazil: case reports with serious cardiac involvement
Provedor de dados: 55
Autores: Pinto,Ana Yecê das Neves; Valente,Sebastião Aldo da Silva; Valente,Vera da Costa.
Four cases of serious cardiac attacks by autochthonous Trypanosoma cruzi infection from the Brazilian Amazon are reported; three of them occurred in micro-epidemic episodes. The manifestations included sudden fever, myalgia, dyspnea and signs of heart failure. Diagnosis was confirmed by specific exams, especially QBC (Quantitative Buffy Coat) and natural xenodiagnosis. Despite treatment with benznidazol, three patients died with serious myocarditis, renal failure and cardiac tamponade. The authors call attention to the emergence of this disease and reveal a previously unknown pathogenicity of T. cruzi strains in this area, added to a non-usual transmission form.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Chagas disease; Trypanosomiasis; Cardiovascular; Brazilian Amazon; Myocarditis.
Ano: 2004
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702004000600010

Incidence of Trypanosoma cruzi transmission through breastfeeding during acute experimental Chagas disease
Provedor de dados: 55
Autores: Martins,Luciamare Perinetti Alves; Castanho,Roberto Esteves Pires; Nogueira,Adriano Barbosa; Silva,Otavio Turolo da; Gusmão,Alex Silva de.
OBJECTIVE: To verify the incidence of T. cruzi transmission through breastfeeding during acute experimental Chagas' disease. METHODS: Fifteen female Swiss mice were mated and, after pregnancy confirmation, placed in individual cages. A few hours after birth, the females were inoculated with 0.1 mL of blood containing approximately 3 x 10(5) trypomastigote forms of Y strain of T. cruzi and continued breastfeeding for 25 days. RESULTS: In 142 offspring examined no infection through breast-feeding was observed. CONCLUSIONS: The low number of trypomastigote forms ingested by the newborn mice combined with biological and biochemical characteristics of blood trypomastigotes may explain the lack of transmission in this experiment.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Trypanosoma cruzi; Foods for pregnant and breastfeeding mothers; Chagas disease.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000200004

In vitro activity of hypnophilin from Lentinus strigosus: a potential prototype for Chagas disease and leishmaniasis chemotherapy
Provedor de dados: 56
Autores: Souza-Fagundes,E.M.; Cota,B.B.; Rosa,L.H.; Romanha,A.J.; Corrêa-Oliveira,R.; Rosa,C.A.; Zani,C.L.; Teixeira-Carvalho,A.; Martins-Filho,O.A.
Hypnophilin and panepoxydone, terpenoids isolated from Lentinus strigosus, have significant inhibitory activity onTrypanosoma cruzi trypanothione reductase (TR). Although they have similar TR inhibitory activity at 10 μg/mL (40.3 μM and 47.6 μM for hypnophilin and panepoxydone, respectively; ~100%), hypnophilin has a slightly greater inhibitory activity (~71%) on T. cruzi amastigote (AMA) growth in vitro as well as on in vitro phytohemagglutinin (PHA)-induced peripheral blood mononuclear (PBMC) proliferation (~70%) compared to panepoxydone (69% AMA inhibition and 91% PBMC inhibition). Hypnophilin and panepoxydone at 1.25 μg/mL had 67% inhibitory activity onLeishmania (Leishmania) amazonensis amastigote-like (AMA-like) growth in vitro. The panepoxydone...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Chagas disease; Leishmaniasis; Chemotherapy; Immunomodulation; Hypnophilin; Lentinus strigosus.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010001100007

Trypanosoma cruzi infection induces up-regulation of cardiac muscarinic acetylcholine receptors in vivo and in vitro
Provedor de dados: 56
Autores: Peraza-Cruces,K.; Gutiérrez-Guédez,L.; Castañeda Perozo,D.; Lankford,C.R.; Rodríguez-Bonfante,C.; Bonfante-Cabarcas,R.
The pathogenesis of chagasic cardiomyopathy is not completely understood, but it has been correlated with parasympathetic denervation (neurogenic theory) and inflammatory activity (immunogenic theory) that could affect heart muscarinic acetylcholine receptor (mAChR) expression. In order to further understand whether neurogenic and/or immunogenic alterations are related to changes in mAChR expression, we studied two models of Trypanosoma cruzi infection: 1) in 3-week-old male Sprague Dawley rats chronically infected with T. cruzi and 2) isolated primary cardiomyocytes co-cultured with T. cruzi and peripheral blood mononuclear cells (PBMC). Using [³H]-quinuclidinylbenzilate ([³H]-QNB) binding assays, we evaluated mAChR expression in homogenates from selected...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Chagas disease; Muscarinic acetylcholine receptor; Super-sensitivity; Trypanosoma cruzi; Immunogenic theory; Neurogenic theory.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2008000900009

Association of Bartonella spp bacteremia with Chagas cardiomyopathy, endocarditis and arrythmias in patients from South America
Provedor de dados: 56
Autores: Corrêa,F.G.; Pontes,C.L.S.; Verzola,R.M.M.; Mateos,J.C.P.; Velho,P.E.N.F.; Schijman,A.G.; Selistre-de-Araujo,H.S.
Infection with Bartonella spp may cause cardiac arrhythmias, myocarditis and endocarditis in humans. The aim of the present study was to evaluate a possible association between Bartonella spp bacteremia and endocarditis, arrhythmia and Chagas cardiomyopathy in patients from Brazil and Argentina. We screened for the presence of bacterial 16S rRNA in human blood by PCR using oligonucleotides to amplify a 185-bp bacterial DNA fragment. Blood samples were taken from four groups of subjects in Brazil and Argentina: i) control patients without clinical disease, ii) patients with negative blood-culture endocarditis, iii) patients with arrhythmias, and iv) patients with chronic Chagas cardiomyopathy. PCR products were analyzed on 1.5% agarose gel to visualize the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Human; PCR; Bartonella spp; Chagas disease; Endocarditis; Arrhythmia.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012000700012

Candida Glabrata Esophagitis: new case reports and management
Provedor de dados: 58
Autores: Macêdo,Danielle Patrícia Cerqueira; Silva,Vanessa Karina Alves da; Farias,Aline Mary de Almeida; Melo,Luciana Resende Bandeira de; Wilheim,Ana Botler; Neves,Rejane Pereira.
Candida esophagitis (CE) is a common opportunistic infection in the immunocompromised host. C. glabrata is rarely cited as agent of CE and has been underestimated due to lack of proper identification. In this study, two cases of C. glabrata esophagitis in AIDS and chagasic patients are reported. Diagnosis of Candida species should be considered an important key for the ideal choice of antifungal therapy against this mycosis.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Candida glabrata; Esophagitis; AIDS; Chagas disease.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822008000200015

Lethal effects of a Mexican Beauveria bassiana (Balsamo) strain against Meccus pallidipennis (Stal)
Provedor de dados: 58
Autores: Lino,Zumaquero Rios José; Juventino,López-Tlacomulco José; Raúl,Rojas García; Estibaliz,Sansinenea.
The entomopathogenic fungus Beauveria bassiana (Balsamo 1835) Vuillemin is an effective alternative control agent against some agricultural pests and biological vectors of important diseases such as Chagas disease. In this work we studied an isolate of Beauveria bassiana from of the town of San Antonio Rayón, Puebla, Mexico and its entomopathogenic effects on Meccus pallidipennis (Stal 1872). Phylogenetic analysis using molecular comparison of the ITS and EF1α genes, showed that the resulting cladogram places the BUAP 04 strain with a relationship closer to the AFAO 9-6 strain, within the diversity of the B. bassiana sensu lato group. Although there was the possibility that BUAP 04 strain was a direct descendant of strains used in campaigns of biologic...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Chagas disease; Biocontrol agent; Triatomines.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822014000200025