Consulta: subjectFacets:"Cholinesterase inhibitor"
Registros recuperados: 4
Data/hora: 04/06/2024 09:47:27

Relation of Breast Cancer and Malathion Aerial Spraying in Arica, Chile
Provedor de dados: 77
Autores: Cabello,Gertrudis; Valenzuela-Estrada,Mario; Siques,Patricia; Brito,Julio; Parra,Eduardo; Valdivia,Ursula; Lavin,Claudia; Manríquez,Alejandra; Ortega,Alejandro.
Breast cancer mortality has been increasing in Arica Chile where it has surpassed the national rates 11 times between 1990 and 2010. The city of Arica was sprayed with the organophosphrous pesticide malathion in order to control the Mediterranean fly 33 years ago. Moreover we have demonstrated that a malathion treatment induces the formation of breast carcinomas in Sprague Dowley female rats. The objective of this work was to find a relationship between malathion aerial spraying and the increased mortality rate due to breast cancer that has been observed in Arica in recent years. We extracted city data bases with all breast cancer cases diagnosed from 1995 to 2005 from the Dr. Juan Noe Crevani Hospital of Arica city and Ernesto Torres Hospital of Iquique....
Tipo: Journal article
Palavras-chave: Pesticides; Organophosphates; Cholinesterase inhibitor; Metastases; Population health.
Ano: 2013
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022013000200048

Two fast screening methods (GC-MS and TLC-ChEI assay) for rapid evaluation of potential anticholinesterasic indole alkaloids in complex mixtures
Provedor de dados: 42
Autores: Vieira,Ivo J.C.; Medeiros,Walter L.B.; Monnerat,Cecilia S.; Souza,Jucimar J.; Mathias,Leda; Braz-Filho,Raimundo; Pinto,Angelo C.; Sousa,Priscila M.; Rezende,Claudia M.; Epifanio,Rosângela De A.
The pharmacotherapyfor Alzheimer's disease (AD) includes the use of acetylcholinesterase inhibitors (AChEI). Recent investigations for novel AD therapeutic agents from plants suggested that Tabernaemontana genus is a promising source of novel anticholinesterasic indole alkaloids. In this work two fast screening techniques were combined in order to easily identify novel cholinesterase inhibitors (ChEI). Gas chromatography-mass spectrometry (GC-MS) of the less polar alkaloidic fractions obtained from the acid-base extraction of the stalk of T. laeta revealed thirteen monoindole alkaloids, four of them confirmed by co-injection with previously isolated alkaloids. The others were tentatively identified by mass fragmentation analysis. By gas chromatography with...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Tabernaemontana; Indole alkaloids; Cholinesterase inhibitor; Thin-layer chromatography assay; Ellman´s method; GC-MS.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652008000300003

Antagonism of morphine-induced central respiratory depression by donepezil in the anesthetized rabbit
Provedor de dados: 48
Autores: TSUJITA,MIKI; SAKURABA,SHIGEKI; KURIBAYASHI,JUNYA; HOSOKAWA,YUKI; HATORI,EIKI; OKADA,YASUMASA; KASHIWAGI,MASANORI; TAKEDA,JUNZO; KUWANA,SHUN-ICHI.
Morphine is often used in cancer pain and postoperative analgesic management but induces respiratory depression. Therefore, there is an ongoing search for drug candidates that can antagonize morphine-induced respiratory depression but have no effect on morphine-induced analgesia. Acetylcholine is an excitatory neurotransmitter in central respiratory control and physostigmine antagonizes morphine-induced respiratory depression. However, physostigmine has not been applied in clinical practice because it has a short action time, among other characteristics. We therefore asked whether donepezil (a long-acting acetylcholinesterase inhibitor used in the treatment of Alzheimer's disease) can antagonize morphine-induced respiratory depression. Using the...
Tipo: Journal article
Palavras-chave: Morphine; Donepezil; Rabbit; Respiratory depression; Alzheimer's disease; Cholinesterase inhibitor.
Ano: 2007
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602007000400008

Donepezil reverses buprenorphine-induced central respiratory depression in anesthetized rabbits
Provedor de dados: 48
Autores: SAKURABA,SHIGEKI; TSUJITA,MIKI; ARISAKA,HIROFUMI; TAKEDA,JUNZO; YOSHIDA,KAZUICHI; KUWANA,SHUN-ICHI.
Buprenorphine is a mixed opioid receptor agonist-antagonist used in acute and chronic pain management. Although this agent's analgesic effect increases in a dose-dependent manner, buprenorphine-induced respiratory depression shows a marked ceiling effect at higher doses, which is considered to be an indicator of safety. Nevertheless, cases of overdose mortality or severe respiratory depression associated with buprenorphine use have been reported. Naloxone can reverse buprenorphine-induced respiratory depression, but is slow-acting and unstable, meaning that new drug candidates able to specifically antagonize buprenorphine-induced respiratory depression are needed in order to enable maximal analgesic effect without respiratory depression. Acetylcholine is...
Tipo: Journal article
Palavras-chave: Buprenorphine; Donepezil; Rabbit; Respiratory depression; Cholinesterase inhibitor.
Ano: 2009
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602009000400008