Consulta: subjectFacets:"Chronic hepatitis B"
Registros recuperados: 10
Data/hora: 01/06/2024 18:04:27

Economic evaluation of treatments for chronic hepatitis B
Provedor de dados: Brazilian Journal of Infectious Diseases
Autores: Wiens,Astrid; Lenzi,Luana; Venson,Rafael; Pedroso,Maria Lúcia Alves; Correr,Cassyano Januário; Pontarolo,Roberto.
The aim of this study was to conduct a cost-utility study of adefovir, entecavir, interferon alpha, pegylated interferon alpha, lamivudine and tenofovir for chronic hepatitis B in the context of Brazilian Public Health Care System. A systematic review was carried out for efficacy and safety. Another review was performed to collect utility data and transition probabilities between health states. A Markov model was developed in a time horizon of 40 years with annual cycles for three groups of: HBeAg positive, HBeAg negative, and all patients. These strategies were compared to a fourth group that received no treatment. Discount rates of 5% were applied and sensitivity analyses were performed. Tenofovir offered the best cost-utility ratio for the three...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Chronic hepatitis B; Economic evaluation; Treatments.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000400006

Prevalence of mutations in HBV DNA polymerase gene associated with nucleos(t)ide resistance in treatment-naive patients with Chronic Hepatitis B in Central China
Provedor de dados: Brazilian Journal of Infectious Diseases
Autores: Zhao,Youyun; Wu,Jianhua; Sun,Lijun; Liu,Guangzhong; Li,Bo; Zheng,Yi; Li,Xiaodong; Tao,Junxiu.
Abstract  Objective There are a lot of disagreements in the studies on hepatitis B virus (HBV) DNA polymerase mutation rate associated with nucleos(t)ide analogues (NAs) in treatment-naive chronic hepatitis B (CHB) patients. This is the first study aimed to investigate the prevalence of spontaneous HBV resistance mutations in Central China.  Methods This study included treatment-naive patients with CHB from June 2012 to May 2015 receiving care at the Institute of Liver Disease in Central China. All patients completed a questionnaire covering different aspects, such as family medical history, course of liver disease, medication history, alcohol use, among others. Mutations in HBV DNA polymerase associated with NAs resistance were detected using INNO-LiPA...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Hepatitis B virus; Chronic hepatitis B; Viral resistance mutations.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000200173

Cost-effectiveness of entecavir versus lamivudine for the suppression of viral replication in chronic hepatitis B Patients in Brazil
Provedor de dados: Brazilian Journal of Infectious Diseases
Autores: Costa,Anna Maria N.; L.'Italien,Gilbert; Nita,Marcelo Eidi; Araujo,Evaldo Stanislau A.
Hepatitis B virus infection is an important public-health issue. Chronic patients have a higher risk of death due to complications, which increases health-care expenses in. Cost-effectiveness analysis of entecavir (ETV) versus lamivudine (LVD) for treatment of chronic hepatitis B, in e antigen (AgHBe)-positive and negative patients, based on two phase 3, controlled and randomized studies. A decision analysis model was developed, using the following endpoints: cost per patient with undetectable viral load and cost per quality life year (QALY) gained. Risks for complications (compensated or decompensated cirrhosis and hepatocellular carcinoma) were based on the cohort study REVEAL, published in 2006. The REVEAL parameters were applied to the results of the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Chronic hepatitis B; Cost; Treatment.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000500005

Profile of users of drugs for the treatment of chronic hepatitis B available through the Brazilian Public Health System
Provedor de dados: Brazilian Journal of Infectious Diseases
Autores: Wiens,Astrid; Lenzi,Luana; Grochocki,Mônica Cavichiolo; Correr,Cassyano Januário; Pontarolo,Roberto.
Treatment for chronic hepatitis B in Brazil are funded by the Ministry of Health and by the state Departments of Health. Clinical protocol and therapeutic guidelines approve the use of adefovir, entecavir, interferon-a, lamivudine, and tenofovir for the treatment of chronic hepatitis B. The aim of this study was to establish the profile of users of these drugs in the state of Paraná. A cross-sectional study was conducted with patients under treatment in Paraná in August 2011. The following data were obtained: gender, hepatitis B used drug, International Classification of Diseases, and regional health unit. The monthly cost of these drugs for the public health system was also calculated. 1,093 patients registered were found, 70% male, and 2.6% co-infected...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Chronic hepatitis B; Users profile; Treatments; Demographic profile.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000400012

Prevalence of HBV genotypes in South American immigrants affected by HBV-related chronic active hepatitis
Provedor de dados: Brazilian Journal of Infectious Diseases
Autores: Palumbo,Emilio; Scotto,Gaetano; Faleo,Giuseppina; Cibelli,Donatella Concetta; Angarano,Gioacchino.
This study evaluated the prevalence of HBV infection in a population of South American immigrants in Italy and to determine in patients with detectable serum HBV-DNA the HBVgenotypes. Between April 2005 and April 2006 a total of 130 South American immigrants were tested for HBsAg. In HBsAg positive patients the biochemical and virological activity of infection and the possible presence of co-infections (HCV, HDV, HIV) were evaluated. In patients with detectable serum HBV DNA, the HBV genotype was determined by INNOLiPA. Among the 130 subjects tested, 14 (10.7%) resulted HBsAg positive. All were men, with a mean age of 22 years (range 19-37) and 12 (85.7 %) came from Brazil, while 2 (14.3%) came from Ecuador. All patients infected by HBV had elevated...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HBV genotypes; Chronic hepatitis B; Immigrants; HBsAg; Viral genome.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000300002

Predictors of HBeAg seroconversion after long-term nucleos(t)ide analogues treatment for chronic hepatitis B: a multicenter study in real clinical setting
Provedor de dados: Brazilian Journal of Infectious Diseases
Autores: Yu,Weiyan; Wang,Yadong; Shen,Chuan; Ji,Ru; Zhang,Li; Zhao,Xin; Su,Miao; Zhang,Ying; He,Wenyan; Cao,Jianguo; Hao,Yanshuang; Chen,Shengpeng; Zhao,Caiyan.
ABSTRACT  Aims: To evaluate the HBeAg seroconversion rate in real clinical setting and explore its predictors in long-term nucleos(t)ide analogues (NAs) treatment for chronic hepatitis B (CHB).  Methods: 251 patients were recruited from January 2001 to September 2009 in four hospitals in Hebei province, China, for this retrospective study. Clinical and laboratory data before and after treatment with lamivudine (LAM, 100 mg daily), adefovir (ADV, 10 mg daily), telbivudine (LDT, 600 mg daily), entecavir (ETV, 0.5 mg daily), and LAM/ADV combination were compared among three groups according to treatment outcomes: synchronous HBeAg loss and HBeAg seroconversion, anti-HBe development after treatment, and no anti-HBe. Adherence was also evaluated.  Results: In...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Chronic hepatitis B; Hepatitis B and antigens; Nucleos(t)ide analogue; Adherence.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000300213

YMDD motif mutations in chronic hepatitis B antiviral treatment naïve patients: a multi-center study
Provedor de dados: Brazilian Journal of Infectious Diseases
Autores: Tan,You-Wen; Ge,Guo-Hong; Zhao,Wei; Gan,Jian-He; Zhao,Yun; Niu,Zhi-Lin; Zhang,Dong-Jun; Chen,Li; Yu,Xue- Jun; Yang,Li-Jun.
OBJECTIVE: This study aimed to determine the natural prevalence of variants of tyrosine-methionine-aspartic acid-aspartic acid (YMDD) motif in patients with chronic hepatitis B (CHB), and to explore its relation with demographic and clinical features, hepatitis B virus (HBV) genotypes, and HBV DNA levels. METHODS: A total of 1,042 antiviral treatment naïve CHB patients (including with lamivudine [LAM]) in the past year were recruited from outpatient and inpatient departments of six centers from December 2008 to June 2010. YMDD variants were analyzed using the HBV drug resistance line probe assay (Inno-Lipa HBV-DR). HBV genotypes were detected with polymerase chain reaction (PCR) microcosmic nucleic acid cross-ELISA, and HBV deoxyribonucleic acid (DNA) was...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: YMDD; Mutations; Chronic hepatitis B; Anti-viral therapy.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000300006

Mutations in the S gene and in the overlapping reverse transcriptase region in chronic hepatitis B Chinese patients with coexistence of HBsAg and anti-HBs
Provedor de dados: Brazilian Journal of Infectious Diseases
Autores: Ding,Feng; Miao,Xi-Li; Li,Yan-Xia; Dai,Jin-Fen; Yu,Hong-Gang.
Abstract  Background The mechanism underlying the coexistence of hepatitis B surface antigen and antibodies to HBsAg in chronic hepatitis B patients remains unknown.  Aims This research aimed to determine the clinical and virological features of the rare pattern.  Methods A total of 32 chronic hepatitis B patients infected by HBV genotype C were included: 15 carrying both HBsAg and anti-HBs (group I) and 17 solely positive for HBsAg (group II). S gene and reverse transcriptase region sequences were amplified, sequenced and compared with the reference sequences.  Results The amino acid variability within major hydrophilic region, especially the “a” determinant region, and within reverse transcriptase for regions overlapping the major hydrophilic region in...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Chronic hepatitis B; Coexistence of HBsAg and anti-HBs; S gene; Reverse transcriptase.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000100001

The regulatory role of IL-6R in hepatitis B-associated fibrosis and cirrhosis
Provedor de dados: Brazilian Journal of Medical and Biological Research
Autores: Chen,Y.; Yang,S.; Peng,Y.; Yang,Z.
This study investigated the expression and regulation of IL-6R in hepatitis B-associated moderate hepatic fibrosis and cirrhosis. Liver tissues, peripheral blood monocytes (PBMs) and serum were collected from 26 hepatitis B patients with liver fibrosis and 35 hepatitis B patients with liver cirrhosis. The levels of Il-6r mRNA expression in these samples were examined by quantitative real-time PCR and IL-6R protein levels were analyzed by western blot and ELISA. MiRNAs that regulate IL-6R expression were predicted by bioinformatics analysis, and validated by dual luciferase reporter assay. Compared with the hepatic fibrosis group, IL-6R was significantly upregulated at both mRNA and protein levels in liver tissues, PBMs and serum samples from the hepatic...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: MiRNA-30b; IL-6 receptor; Chronic hepatitis B; Fibrosis; Cirrhosis.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2017001100610

Serum microRNA-30c levels are correlated with disease progression in Xinjiang Uygur patients with chronic hepatitis B
Provedor de dados: Brazilian Journal of Medical and Biological Research
Autores: Zhang,J.; Ma,J.; Wang,H.; Guo,L.; Li,J.
We aimed to investigate the potential role and mechanism of microRNA-30c (miR-30c) in the pathological development of chronic hepatitis B (CHB). The serum levels of miR-30c in hepatitis B virus (HBV) carrier Xinjiang Uygur patients with inactive, low-replicative, high-replicative and HBe antigen-positive CHB were investigated. HepG2 cells were co-transfected with pHBV1.3 and miR-30c mimic or inhibitor or scramble RNA. The effects of miR-30c dysregulation on HBV replication and gene expression, cell proliferation and cell cycle were then investigated. miR-30c was down-regulated in Xinjiang Uygur patients with CHB compared to healthy controls and its expression level discriminated HBV carrier patients with inactive, low-replicative, high-replicative and HBe...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Chronic hepatitis B; Disease progression; MicroRNA-30c; Hepatitis B virus replication; Cell proliferation.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2017000600601