Consulta: subjectFacets:"Cryptococcal meningitis"
Registros recuperados: 4
Data/hora: 16/06/2024 16:15:29

Cerebral infarction related to cryptococcal meningitis in an HIV-infected patient: case report and literature review
Provedor de dados: Brazilian Journal of Infectious Diseases
Autores: Leite,Andréa Gurgel Batista; Vidal,José E.; Bonasser Filho,Francisco; Nogueira,Roberta Schiavon; Oliveira,Augusto César Penalva de.
Neurological dysfunction as the first manifestation of AIDS has been found in 10 to 20% of symptomatic human immunodeficiency virus infections. However, stroke has rarely been reported in AIDS patients. The most common causes of cerebral infarction in AIDS are central nervous system infections: toxoplasmosis, cryptococcal meningitis and tuberculosis. Potential vascular mechanisms for cerebral infarction and transient neurological deficits among AIDS patients include deposition of antigen-antibody complexes with vasculitis and infarction, and a direct toxic effect of a viral antigen or infectious agent on vascular endothelium. The role of cryptococcal meningitis in vasculopathy is still not clear. We report a case of cerebral infarction in an HIV-infected...
Tipo: Info:eu-repo/semantics/report
Palavras-chave: AIDS; Cerebral infarction; Stroke; Cryptococcal meningitis.
Ano: 2004
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702004000200008

Efficacy of amphotericin B in a fat emulsion for the treatment of cryptococcal meningitis in AIDS patients
Provedor de dados: Brazilian Journal of Infectious Diseases
Autores: Rubio,Fernando Góngora; Zanon,Jeferson Rodrigo; Almeida,Margarete Teresa Gottardo de; Góngora,Delzi Vinha Nunes de.
Several formulae have been developed in an attempt to reduce the toxicity of amphotericin B (AmB), but their high costs preclude widespread use. The aim of this study was to evaluate the efficacy of amphotericin B in a fat emulsion, i.e. Intralipid (AmB-IL), in 37 AIDS patients with cryptococcal meningitis (CM). We retrospectively reviewed data collected in a non-comparative open study between January 1999 and December 2001. The therapeutic cure was defined as complete resolution or improvement of the clinical symptoms or complete absence or improvement of the mycological alterations of the CSF. The outcomes were evaluated at 2 weeks, induction phase (IP), and at the end of treatment or consolidation phase (CP) with the last available CSF. Prior to the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Amphotericin B; Fat emulsion; Cryptococcal meningitis; AIDS patients.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000200006

Molecular diagnosis of cryptococcal meningitis in cerebrospinal ﬂuid: comparison of primer sets for Cryptococcus neoformans and Cryptococcus gattii species complex
Provedor de dados: Brazilian Journal of Infectious Diseases
Autores: Martins,Marilena dos Anjos; Brighente,Kate Bastos Santos; Matos,Terezinha Aparecida de; Vidal,Jose Ernesto; Hipólito,Daise Damaris Carnietto de; Pereira-Chioccola,Vera Lucia.
Aim:This study evaluated the use of polymerase chain reaction for cryptococcal meningitis diagnosis in clinical samples.Materials and methods:The sensitivity and speciﬁcity of the methodology were evaluated using eight Cryptococcus neoformans/C. gattiispecies complex reference strains and 165 cere- brospinal ﬂuid samples from patients with neurological diseases divided into two groups: 96 patients with cryptococcal meningitis and AIDS; and 69 patients with other neurological opportunistic diseases (CRL/AIDS). Two primer sets were tested (CN4-CN5 and the multiplex CNa70S-CNa70A/CNb49S-CNb-49A that amplify a speciﬁc product for C. neoformansand another for C. gattii).Results:CN4-CN5 primer set was positive in all Cryptococcusstandard strains and in 94.8% in...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Cryptococcal meningitis; Acquired immunodeﬁciency syndrome; Polymerase chain reaction; Cerebrospinal ﬂuid.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000100062

Strategies to reduce mortality and morbidity due to AIDS-related cryptococcal meningitis in Latin America
Provedor de dados: Brazilian Journal of Infectious Diseases
Autores: Vidal,Jose E.; Oliveira,Augusto C. Penalva de; Dauar,Rafi F.; Boulware,David R.
Latin America is the region with the third most AIDS-related cryptococcal meningitis infections globally. Highly active antiretroviral therapy (HAART) has reduced the number of infections; however, the number of deaths and the case-fatality rate continues to be unacceptable. In this review, we focus on the burden of AIDS-related cryptococcosis in Latin America and discuss potential strategies to reduce early mortality from Cryptococcus. In this review, we highlight the importance of: (1) earlier HIV diagnosis and HAART initiation with retention-in-care to avoid AIDS; (2) pre-HAART cryptococcal antigen (CRAG) screening with preemptive fluconazole treatment; (3) better diagnostics (e.g. CRAG testing); and (4) optimal treatment with aggressive management of...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Cryptococcal meningitis; Cryptococccosis; Epidemiology; Diagnosis; Treatment; Mortality; Latin America.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000300008