Consulta: subjectFacets:"Cysteamine"
Registros recuperados: 2
Data/hora: 01/06/2024 02:43:40

Chemoprotective effect of cysteamine against the induction of micronuclei by methyl methanesulfonate and cyclophosphamide
Provedor de dados: 74
Autores: Santos-Mello,Renato; Deimling,Luiz Irineu; Lauer Júnior,Claudio; Carvalho,Thaís Rieger de.
Cysteamine or 2-mercaptoethylamine (MEA) is an aminothiol with a well-known radioprotective action. No specific information is available in the literature about the possible chemoprotective action of MEA against genotoxic chemical agents. This paper presents the results of studies on the ability of MEA to protect mouse bone marrow polychromatic erythrocytes against the induction of micronuclei by alkylating agents such as methyl methanesulfonate (MMS) and cyclophosphamide (CP). We observed that MEA administered intraperitoneally 30 min before or 30 min after the administration of MMS or CP significantly reduced the frequency of micronucleated polychromatic erythrocytes (MNPCEs) induced by the alkylating agents. When MEA was administered in combination with...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Cysteamine; MEA; Micronuclei; Amifostine; WR-2721.
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572005000100027

Thiol/disulfide status regulates the activity of thiol-containing kinases related to energy homeostasis in rat kidney
Provedor de dados: 42
Autores: RECH,VIRGINIA C.; MEZZOMO,NATHANA J.; ATHAYDES,GENARO A.; FEKSA,LUCIANE R.; FIGUEIREDO,VANDRÉ C.; KESSLER,ADRIANA; FRANCESCHI,ITIANE D. DE; WANNMACHER,CLOVIS M.D.
ABSTRACT Considering that thiol-containing enzymes like kinases are critical for several metabolic pathways and energy homeostasis, we investigated the effects of cystine dimethyl ester and/or cysteamine administration on kinases crucial for energy metabolism in the kidney of Wistar rats. Animals were injected twice a day with 1.6 µmol/g body weight cystine dimethyl ester and/or 0.26 µmol/g body weight cysteamine from the 16th to the 20th postpartum day and euthanized after 12 hours. Pyruvate kinase, adenylate kinase, creatine kinase activities and thiol/disulfide ratio were determined. Cystine dimethyl ester administration reduced thiol/disulfide ratio and inhibited the kinases activities. Cysteamine administration increased the thiol/disulfide ratio and...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Cysteamine; Cystine dimethyl ester; Kinases activities; Renal energy metabolism.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652018000100099