Consulta: subjectFacets:"Cytotoxic"
Registros recuperados: 14
Data/hora: 03/06/2024 18:43:34

Protective effect of Hemidesmus indicus R.Br. root extract against cisplatin-induced cytogenetic damage in mouse bone marrow cells
Provedor de dados: 74
Autores: Ananthi,Rajagopal; Chandra,Nallathambi; Santhiya,Sathiyavedu T.
The aqueous extract of Hemidesmus indicus roots was investigated for its in vivo antigenotoxic effect against cisplatin-induced cytogenetic damage. Swiss albino mice were administered with various doses of the extract either singly (50, 100 and 200 mg/kg body weight) or as split doses (10, 20 and 40 mg/kg bw/day) for five consecutive days by oral gavage. As endpoints, chromosome aberrations, micronuclei in polychromatic erythrocytes, mitotic index and PCE/NCE ratio were estimated. The extract protected the bone marrow cells from cisplatin-induced genotoxicity in an inverse dose-dependent manner. However, the extract was cytotoxic at all doses. But, under split dose regime it conferred a higher level of genoprotection and was not cytotoxic at the lower two...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Genoprotective; Cytotoxic; Chromosomal aberrations; Micronucleus; Mitotic index.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572010000100030

Bioactive Indole Derivatives from the South Pacific Marine Sponges Rhopaloeides odorabile and Hyrtios sp.
Provedor de dados: 5
Autores: Longeon, Arlette; Copp, Brent R.; Quevrain, Elodie; Roue, Melanie; Kientz, Betty; Cresteil, Thierry; Petek, Sylvain; Debitus, Cecile; Bourguet-kondracki, Marie-lise.
Indole derivatives including bromoindoles have been isolated from the South Pacific marine sponges Rhopaloeides odorabile and Hyrtios sp. Their structures were established through analysis of mass spectra and 1D and 2D NMR spectroscopic data. Their potential inhibitory phospholipase A(2) (PLA(2)), antioxidant and cytotoxic activities were evaluated. The new derivative 5,6-dibromo-L-hypaphorine (9) isolated from Hyrtios sp. revealed a weak bee venom PLA2 inhibition (IC50 0.2 mM) and a significant antioxidant activity with an Oxygen Radical Absorbance Capacity (ORAC) value of 0.22. The sesquiterpene aureol (4), also isolated from Hyrtios sp., showed the most potent antioxidant activity with an ORAC value of 0.29.
Tipo: Text
Palavras-chave: Indole derivatives; Bromoindoles; Marine sponge; Rhopaloeides odorabile; Hyrtios sp.; PLA(2) inhibitor; Antioxidant; Cytotoxic.
Ano: 2011
URL: https://archimer.ifremer.fr/doc/00214/32485/30975.pdf

Cytotoxic effect of ICD-85 (venom-derived peptides) on MDA-MB-231 cell line
Provedor de dados: 80
Autores: Zare Mirakabadi,A; Mahdavi,S; Koohi,MK; Taghavian,M.
Since 1987, when chemopreventive testing programs began, more than 1,000 agents and agent combinations have been selected and evaluated in preclinical studies of chemopreventive activity against various types of cancers. In the present study we aimed to provide quantitative and qualitative characterization of biological and pharmacological activities of ICD-85 on MDA-MB-231 cell line (a highly invasive breast cancer cell line) in order to gain a better understanding of the cytotoxic and apoptotic effects of this compound. For this study, the MDA-MB-231 cell line was used and the effect of ICD-85 was assayed by measuring the activity of the cytosolic enzyme lactate dehydrogenase (LDH), released into the culture medium after membrane damage. Morphological...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Venom peptides; MDA-MB-231; Anticancer; Necrosis; Cytotoxic.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992008000400005

An antimalarial cembranolide from Tanzania soft corals, Lobophytum crassum (von Marenzeller (1886) and L. rotundum (Tixier-Durivault (1957)
Provedor de dados: 20
Autores: Said, S.A.
Bioscreening guided fractionation of the extracts of soft corals Lobophytum crassum and L. rotundum using brine shrimp larvae cytotoxicity assay led to the isolation of a cembranolide diterpene (E,E,E)-6,10,14-trimethyl-3-methylene- 3a,4,7,8,11,12,15,15aoctahydrocylotetradeca [b]furan-2(3H)-one (1). This diterpene, identified as cembranolide compound 1, was found to be active against the multidrug-resistant and chloroquine-sensitive strains of Plasmodium falciparum malaria parasite in vitro. It also possessed cytotoxic properties.
Tipo: Journal Contribution
Palavras-chave: Lobophytum crassum; L. rotundum; Plasmodium falciparum; Antimalarial; Soft corals; Cytotoxic; Cembranolide Parasites Coral reefs Brine shrimp eggs Parasites http://aims.fao.org/aos/agrovoc/c_5574.
Ano: 2005
URL: http://hdl.handle.net/1834/1139

Free radical scavenging capacity and cytotoxic and antiproliferative effects of Vaccinium meridionale Sw. agains colon cancer cell lines
Provedor de dados: 98
Autores: Maldonado-Celis,Maria E; Arango-Varela,Sandra Sulay; Rojano,Benjamín Alberto.
Introduction: Vaccinium meridionale Swartz, of the family Ericaceae, is commonly known as mortiño or agraz. The plant is considered a functional food, with a content of anthocyanins and antioxidants similar to or greater than that reported for other Vaccinium species. However, little is known about its nutraceutical and medicinal properties. Objectives: determine the antioxidant activity and cytotoxic and antiproliferative effect of mortiño fruit aqueous extract against colon adenocarcinoma cells (SW480) and their derived metastatic cells (SW620). Methods: total phenols and anthocyanins were determined by the Folin-Ciocalteu method. Caffeoyl derivatives were determined by HPLC-DAD. Antioxidant activity was analyzed as the ability to scavenge reactive...
Tipo: Journal article
Palavras-chave: Cytotoxic; Antiproliferative; Free radicals; Vaccinium meridionale; Colon cancer.
Ano: 2014
URL: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1028-47962014000200006

Isolation, characterization and evaluation of antimicrobial and cytotoxic activity of estragole, obtained from the essential oil of croton zehntneri (euphorbiaceae)
Provedor de dados: 42
Autores: ANDRADE,THALLITA C.B.; LIMA,SIDNEY G. DE; FREITAS,RIVELILSON M.; ROCHA,MÁRCIO S.; ISLAM,TOREQUL; SILVA,TERESINHA G. DA; MILITÃO,GARDENIA C.G.
Croton zehntneri (Euphorbiaceae) is a native aromatic plant from Northeast region of Brazil. The monoterpenoid estragole (ESL) has been isolated by classical chromatographic methods from the essential oil (EO) of C. zehnteneri leaves and characterized by GC-FID and GC-MS, its antimicrobial and cytotoxic potentials being assessed. The analysis of the EO enabled the identification of 100% of the integrated constituents, of which yield was about 1.8%. The main components identified were: eucalyptol, estragole (84.7%) and spathulenol. The dosage of 50 μg/disk of ESL presented fairly significant zones of inhibition against Gram-positive bacteria and fungi. The ESL presented toxicity against Artemia salina with LC50 and LC90 of 4,54 and 8,47 μg mL-1. However, in...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Antimicrobial; Croton zehntneri; Cytotoxic; Estragole.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652015000100173

Antioxidant potential and cytotoxic activity of two red seaweed species, Amansia multifida and Meristiella echinocarpa, from the coast of Northeastern Brazil
Provedor de dados: 42
Autores: ALENCAR,DANIEL B. DE; SILVA,SUZETE R. DA; PIRES-CAVALCANTE,KELMA M.S.; LIMA,REBECA L. DE; PEREIRA JÚNIOR,FRANCISCO N.; SOUSA,MÁRCIA B. DE; VIANA,FRANCISCO A.; NAGANO,CELSO S.; NASCIMENTO,KYRIA S. DO; CAVADA,BENILDO S.; SAMPAIO,ALEXANDRE H.; SAKER-SAMPAIO,SILVANA.
Natural antioxidants found in marine macroalgae are bioactive compounds known to play an important role in the prevention of diseases associated with aging cells protecting them against the oxidative damage. The purpose of this study was to evaluate the antioxidant and cytotoxic activity of ethanolic extracts of two species of red seaweeds, Amansia multifida and Meristiella echinocarpa. In vitro antioxidant activity was determined by DPPH radical scavenging assay, ferric-reducing antioxidant power (FRAP) assay, ferrous ion chelating (FIC) assay, β-carotene bleaching (BCB) assay and total phenolic content (TPC) quantification. Cytotoxicity was evaluated with the brine shrimp Artemia sp. lethality test. The TPC values observed in the present study indicated...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Antioxidant; Bioactive compounds; Cytotoxic; Phenolic compounds; Rhodophyta.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652014000100251

In vitro cytotoxic, antifungal, trypanocidal and leishmanicidal activities of acetogenins isolated from Annona cornifolia A. St. -Hil. (Annonaceae)
Provedor de dados: 42
Autores: LIMA,LUCIANA A.R.S.; ALVES,TÂNIA M.A.; ZANI,CARLOS L.; SALES JÚNIOR,POLICARPO A.; ROMANHA,ALVARO J.; JOHANN,SUSANA; CISALPINO,PATRÍCIA S.; PIMENTA,LÚCIA P.S.; BOAVENTURA,MARIA AMÉLIA D.
Annona cornifolia A. St. -Hil. is a small annual perennial tree found in the Brazilian savannah; their green fruit is popularly used in the treatment of ulcers. The acetogenins isolated from the seeds of Annona cornifolia previously showed to possess antioxidant activity. In continuation of our investigations on the biological activities of acetogenins, four binary mixtures and ten pure adjacent bis-tetrahydrofuran annonaceous acetogenins were evaluated: the cytotoxic (against three human tumor cell lines), antifungal (against Paracoccidioides brasiliensis), trypanocidal (against Trypanosoma cruzi) and leishmanicidal (against Leishmania amazonensis) activities. Acetogenins presented cytotoxic activity confirming their potential use in anti-cancer therapy....
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Annona cornifolia; Acetogenins; Cytotoxic; Antifungal; Trypanocidal; Leishmanicidal.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652014000200829

Evaluation of genotoxic and cytotoxic effects of hydroalcoholic extract of Euphorbia tirucalli (Euphorbiaceae) in cell cultures of human leukocytes
Provedor de dados: 42
Autores: Machado,Michel M.; Oliveira,Luis F.S. de; Zuravski,Luisa; Souza,Raul O. de; Fischer,Paula; Duarte,Jonathaline A.; Rocha,Manoelly O.; Güez,Camila M.; Boligon,Aline A.; Athayde,Margareth L.
ABSTRACT Euphorbia tirucalli (L.), commonly known as aveloz, has been indiscriminately used in popular medicine to treat various illnesses. However, some components can have devastating consequences. Injury to a cell's genetic material can cause mutations, cancer, and cell death. Our main goal in this work was to evaluate the genotoxic and cytotoxic effects of E. tirucalli extract on human leukocytes. For this purpose, we performed a phytochemical analysis to evaluate the plant's components. In the second step, we treated cultured human leukocytes with different concentrations of the dry extract of the plant and then evaluated the oxidative and genotoxic profiles of these leukocytes. We found that at 1% and 10% concentrations, the aveloz extract acted as a...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Aveloz; Euphorbia tirucalli; Leukocytes; Genotoxic; Cytotoxic.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652016000100017

Antibacterial and cytotoxicity activities and phytochemical analysis of three ornamental plants grown in Mexico
Provedor de dados: 42
Autores: RÍOS-CHÁVEZ,PATRICIA; PEREZ-GONZALEZ,JORDY; SALGADO-GARCIGLIA,RAFAEL; RAMÍREZ-CHÁVEZ,ENRIQUE; MOLINA-TORRES,JORGE; MARTINEZ-TRUJILLO,MIGUEL; CARREON-ABUD,YAZMIN.
Abstract: This study evaluates the antibacterial, cytotoxic activities, and phytochemical composition, of Callistemon citrinus, Hibiscus rosa-sinensis and Plumbago auriculata leaves and flowers, three ornamental plants in Mexico. However, in other countries offers a range of other uses. Ethanol extracts of C. citrinus leaf and flower presented stronger antibacterial activity than the extracts obtained from the other two plants. C. citrinus leaf showed low cytotoxicity (LC50 &lt;600 µg/mL) on the brine shrimp test, whereas the ethanol extracts of H. rosa-sinensis and P. auriculata leaves showed no cytotoxic activity. Flower extracts obtained from the three plants did no exhibit cytotoxicity. GC-MS analysis revealed that the ethanol extract of P. auriculata...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Antibacterial; Artemia salina; Callistemon citrinus; Cytotoxic; Lupeol.
Ano: 2019
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652019000300611

Evaluation of cytotoxic potential of latex of Calotropis procera and Podophyllotoxin in Allum cepa root model
Provedor de dados: 47
Autores: Sehgal,R.; Roy,S.; Kumar,V.L.
In the present study we have utilized the Allium cepa root tip meristem model to evaluate the cytotoxic and anti-mitotic activities of latex of Calotropis procera (DL) and podophyllotoxin. Standard cytotoxic drug cyclophosphamide and non-cytotoxic drugs cyproheptadine and aspirin served as controls. Like cyclophosphamide, both DL and podophyllotoxin significantly inhibited the growth of roots and mitotic activity in a dose-dependent manner. However, podophyllotoxin was more potent in this regard and produced root decay. Cyproheptadine and aspirin, on the other hand, showed a marginal effect on the root growth and mitotic activity at much higher concentrations.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Calotropis procera; Podophyllotoxin; Cyclophosphamide; Cytotoxic; Allium cepa.
Ano: 2006
URL: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0327-95452006000100002

In vivo antipyretic, antiemetic, in vitro membrane stabilization, antimicrobial, and cytotoxic activities of different extracts from Spilanthes paniculata leaves
Provedor de dados: 48
Autores: Hossain,Mohammad Mobarak; Ahamed,Sayed Koushik; Dewan,Syed Masudur Rahman; Hassan,Md Mahadi; Istiaq,Arif; Islam,Mohammad Safiqul; Moghal,Md Mizanur Rahman.
BACKGROUND: The study was conducted to evaluate the in vitro antimicrobial activity, cytotoxic, and membrane stabilization activities, and in vivo antiemetic and antipyretic potentials of ethanolic extract, n-hexane and ethyl acetate soluble fractions of Spilanthes paniculata leaves for the first time widely used in the traditional treatments in Bangladesh. RESULTS: In antipyretic activity assay, a significant reduction (P &lt; 0.05) was observed in the temperature in the mice tested. At dose 400 mg/kg-body weight, the n-hexane soluble fraction showed the effect (36.7 ± 0.63°C ) as like as the standard (dose 150 mg/kg-body weight) after 5 h of administration. Extracts showed significant (P &lt; 0.001) potential when tested for the antiemetic activity...
Tipo: Journal article
Palavras-chave: Antiemetic; Anti-inflammatory; Antimicrobial activity; Brine shrimp lethality bioassay; Cytotoxic; Membrane stabilization; Spilanthes paniculata.
Ano: 2014
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602014000100045

Passiflora mucronata leaves extracts obtained from different methodologies: a phytochemical study based on cytotoxic and apoptosis activities of triterpenes and phytosterols constituents
Provedor de dados: 60
Autores: Silva,Isabel Cristina Vieira da; Oliveira,Pollyana Felix de; Barbosa,Gleyce Moreno; Wessjohann,Ludger A.; Cardozo-Filho,Lucio; Holandino,Carla; Muzitano,Michelle Frazão; Leal,Ivana Correa Ramos.
Cancer is one of the most prevalent diseases worldwide and the natural products could be a source of bioactive compounds. Passiflora mucronata (PM) belongs to a very known vegetal genus, although, there are no studies about cytotoxic activity or isolated compounds. Different extracts from PM were obtained by liquid-liquid partition (P), Soxhlet (Sox) and supercritical fluid (SFE1-5) extraction techniques, being compared concerning their yields, chemical profile and cytotoxicity. The Sox extracts showed the highest yields (6.03%: hexane; 2.51%: dichloromethane) followed by SFE (from 4.34 to 1.63%) and partitions (1.06 and 2.26%). The hexane partition (HP) showed the best cytotoxic activity against K562 cell line (IC50 = 18.72 µg.mL-1). From HP, the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Apoptosis; Cytotoxic; Passiflora mucronata; Stigmasterol; Triterpenes.
Ano: 2020
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100510

Bioisosteric modification on melatonin: synthesis of new naphthalene derivatives, in vitro antioxidant activity and cytotoxicity studies
Provedor de dados: 60
Autores: Shirinzadeh,Hanif; Ghalia,Mohammed; Tascioglu,Alev; Adjali,Ferial Intissar; Gunesacar,Gulsen; Gurer-Orhan,Hande; Suzen,Sibel.
Melatonin (MLT) is a strong free radical scavenger that protects the body from the deleterious effects of excess oxidants. Synthesis of MLT analogue compounds with antioxidant potency has recently attracted the interest of researchers. In general, the strategy consists of modifying the groups in the different sites of the indole ring or replacing the indole ring with an analogue. As part of our ongoing research, the antioxidant capacity and cytotoxicity of newly synthesized MLT analogue naphthalene derivatives were evaluated. The radical scavenging activity was tested by a 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay. Most of the synthesized compounds showed significant antioxidant activity in comparison to MLT. The structure-activity relationship was...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Antioxidant; Cytotoxic; Melatonin; MTT; DPPH.
Ano: 2020
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100550