Consulta: subjectFacets:"Delta32ccr5 Frequency allele"
Registros recuperados: 1
Data/hora: 11/06/2024 05:41:59

CCR5 genotype and plasma ß-chemokine concentration of Brazilian HIV-infected individuals
Provedor de dados: Brazilian Journal of Medical and Biological Research
Autores: Mikawa,A.Y.; Tagliavini,S.A.; Costa,P.I.
The 32-bp deletion in the HIV-1 co-receptor CCR5 confers a high degree of resistance to HIV-1 infection in homozygous individuals for the deleted allele and partial protection against HIV-1 during disease progression in heterozygotes. Natural ligands for CCR5, MIP-1alpha, MIP-1ß and RANTES, have been shown to inhibit HIV replication in CD4+ T cells. In the present study, we examined the CCR5 genotype by PCR and the plasma levels of RANTES and MIP-1alpha by ELISA among blood donors (N = 26) and among HIV-1-infected individuals (N = 129). The control group consisted of healthy adult volunteers and HIV-1-infected subjects were an asymptomatic and heterogeneous group of individuals with regard to immunologic and virologic markers of HIV-1 disease. The...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: HIV-1; CC chemokine receptor 5; Delta32ccr5 Frequency allele; Chemokines.
Ano: 2002
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002001100011