Consulta: subjectFacets:"Donor lymphocyte infusion"
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Data/hora: 17/06/2024 14:57:18

Immunological effects of donor lymphocyte infusion in patients with chronic myelogenous leukemia relapsing after bone marrow transplantation
Provedor de dados: 56
Autores: Castro,F.A.; Palma,P.V.B.; Morais,F.R.; Voltarelli,J.C.
Allogeneic bone marrow transplantation (alloBMT) is the only curative therapy for chronic myelogenous leukemia (CML). This success is explained by the delivery of high doses of antineoplastic agents followed by the rescue of marrow function and the induction of graft-versus-leukemia reaction mediated by allogeneic lymphocytes against host tumor cells. This reaction can also be induced by donor lymphocyte infusion (DLI) producing remission in most patients with CML who relapse after alloBMT. The immunological mechanisms involved in DLI therapy are poorly understood. We studied five CML patients in the chronic phase, who received DLI after relapsing from an HLA-identical BMT. Using flow cytometry we evaluated cellular activation and apoptosis, NK...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Chronic myelogenous leukemia; Donor lymphocyte infusion; Immune system; Bone marrow transplantation.
Ano: 2004
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2004000200006