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In ovo administration of human recombinant leptin shows dose dependent angiogenic effect on chicken chorioallantoic membrane
Provedor de dados: 48
Autores: Manjunathan,Reji; Ragunathan,Malathi.
BACKGROUND: Leptin, the cytokine produced by white adipose tissue is known to regulate food energy homeostasis through its hypothalamic receptor. In vitro studies have demonstrated that leptin plays a major role in angiogenesis through binding to the receptor Ob-R present on ECs by stimulating and initiating new capillary like structures from ECs. Various in vivo studies indicate that leptin has diverse effect on angiogenesis. A few reports have showed that leptin exerts pro angiogenic effects while some suggested that it has antiangiogenic potential. It is theoretically highly important to understand the effect of leptin on angiogenesis to use as a therapeutic molecule in various angiogenesis related pathological conditions. Chicken chorio allantoic...
Tipo: Journal article
Palavras-chave: Angiogenesis; HRL; Human Recombinant Leptin; CAM; Chorioallantoic membrane; ECs; Endothelial cells; VEGF; Vascular endothelial growth factor; MMP; Matrix metalloproteinase; Blood vessels; CD34.
Ano: 2015
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602015000100029