Consulta: subjectFacets:"Ehrlich Ascites Carcinoma"
Registros recuperados: 1
Data/hora: 10/06/2024 17:06:35

Antitumor efficacy of EDTA co-treatment with cisplatin in tumor-bearing mice
Provedor de dados: Brazilian Journal of Pharmaceutical Sciences
Autores: El-Naggar,Sabry Ali; El-Said,Karim Samy.
Ethylenediamine tetraacetic acid (EDTA) is used in various medical applications. The aim of this study is to investigate the antitumor efficacy of EDTA alone or with cisplatin (Cis). Fifty male albino mice were used to assess the median lethal dose (LD50) of EDTA via intraperitoneal (i.p) injection. To determine the antitumor activity, fifty female albino mice were divided into five groups as the following; Group 1 (Gp1) was negative control; (Gp2-5) inoculated i.p with 2×106 Ehrlich Ascites Carcinoma (EAC) cells/mouse. After one day, Gp3, Gp4 and Gp5 injected with Cis (2 mg/kg), EDTA (25 mg/kg) and Cis (2 mg/kg)/EDTA (25 mg/kg) for six days, respectively. At day 14, all groups were sacrificed to assess the tumor profile, liver enzymes (alanine...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Cisplatin; Ethylenediamine tetraacetic acid (EDTA)/Antitumor efficacy; Ehrlich Ascites Carcinoma.
Ano: 2020
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100571