Consulta: subjectFacets:"Endostatin"
Registros recuperados: 2
Data/hora: 09/06/2024 06:38:19

COL18A1 is highly expressed during human adipocyte differentiation and the SNP c.1136C &gt; T in its "frizzled" motif is associated with obesity in diabetes type 2 patients
Provedor de dados: Anais da Academia Brasileira de Ciências
Autores: Errera,Flavia I.V.; Canani,Luís H.; Yeh,Erika; Kague,Érika; Armelin-Corrêa,Lucia M.; Suzuki,Oscar T.; Tschiedel,Balduíno; Silva,Maria Elizabeth R.; Sertié,Andréa L.; Passos-Bueno,Maria Rita.
Collagen XVIII can generate two fragments, NC11-728 containing a frizzled motif which possibly acts in Wnt signaling and Endostatin, which is cleaved from the NC1 and is a potent inhibitor of angiogenesis. Collagen XVIII and Wnt signaling have recently been associated with adipogenic differentiation and obesity in some animal models, but not in humans. In the present report, we have shown that COL18A1 expression increases during human adipogenic differentiation. We also tested if polymorphisms in the Frizzled (c.1136C&gt;T; Thr379Met) and Endostatin (c.4349G&gt;A; Asp1437Asn) regions contribute towards susceptibility to obesity in patients with type 2 diabetes (113 obese, BMI =30; 232 non-obese, BMI &lt; 30) of European ancestry. No evidence of association...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: COL18A1; Obesity; Adipogenesis; Endostatin; Frizzled.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652008000100012

Collagen XVIII/endostatin expression in experimental endotoxemic acute renal failure
Provedor de dados: Brazilian Journal of Medical and Biological Research
Autores: Cichy,M.C.; Rocha,F.G.G.; Tristão,V.R.; Pessoa,E.A.; Cenedeze,M.A.; Nürmberg Junior,R.; Schor,N.; Bellini,M.H.
Acute renal failure (ARF) is a frequent complication of Gram-negative sepsis, with a high risk of mortality. Lipopolysaccharide (LPS)-induced ARF is associated with hemodynamic changes that are strongly influenced by the overproduction of nitric oxide (NO) through the cytokine-mediated up-regulation of inducible NO synthase. LPS-induced reductions in systemic vascular resistance paradoxically culminate in renal vasoconstriction. Collagen XVIII is an important component of the extracellular matrix expressed in basement membranes. Its degradation by matrix metalloproteases, cathepsins and elastases results in the formation of endostatin, claimed to have antiangiogenic activity and to be a prominent vasorelaxing agent. We evaluated the expression of...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Acute renal failure; Lipopolysaccharide; Gene expression; Endostatin; CD31.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009001200005