Consulta: subjectFacets:"Endothelium-derived relaxing factors"
Registros recuperados: 1
Data/hora: 13/06/2024 19:25:00

Endothelial mediators of 17ß-estradiol-induced coronary vasodilation in the isolated rat heart
Provedor de dados: 56
Autores: Santos,R.L.; Abreu,G.R.; Bissoli,N.S.; Moysés,M.R.
The present study was designed to determine relaxation in response to 17ß-estradiol by isolated perfused hearts from intact normotensive male and female rats as well as the contribution of endothelium and its relaxing factors to this action. Baseline coronary perfusion pressure was determined and the vasoactive effects of 17ß-estradiol (10 µM) were assessed by in bolus administration before and after endothelium denudation by infusion of 0.25 µM sodium deoxycholate or perfusion with 100 µM L-NAME, 2.8 µM indomethacin, 0.75 µM clotrimazole, 100 µM L-NAME plus 2.8 µM indomethacin, and 100 µM L-NAME plus 0.75 µM clotrimazole. Baseline coronary perfusion pressure differed significantly between males (84 ± 2 mmHg, N = 61) and females (102 ± 2 mmHg, N = 61)....
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Estrogen; Vasodilation; Endothelium-derived relaxing factors; Coronary arteries.
Ano: 2004
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2004000400014