Consulta: subjectFacets:"Fogo selvagem"
Registros recuperados: 4
Data/hora: 09/06/2024 17:33:49

CTLA4 CT60 gene polymorphism is not associated with differential susceptibility to pemphigus foliaceus
Provedor de dados: 74
Autores: Pincerati,Márcia Regina; Dalla-Costa,Ricardo; Petzl-Erler,Maria Luiza.
Pemphigus foliaceus is an organ-specific autoimmune disease characterized by autoantibodies against the extracellular region of desmoglein 1, a protein that mediates intercellular adhesion in desmosomes. Cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) is a key negative regulator of the T cell immune response, playing an important role in T cell homeostasis and maintenance of peripheral tolerance. Polymorphisms in the CTLA4 gene have been associated with autoimmune diseases and the functional CT60 single nucleotide polymorphism (rs3087243, also named 6230G &gt; A) has been proposed to be a casual variant in several of these diseases. The aim of this study was to ascertain whether this polymorphism is associated with inter-individual variation in...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: CTLA4; CT60 polymorphism; Pemphigus; Fogo selvagem; Autoimmunity.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572010000300008

Dermal dendritic cell number correlates with serum autoantibody titers in Brazilian pemphigus foliaceus patients
Provedor de dados: 56
Autores: Chiossi,M.P.V.; Costa,R.S.; Roselino,A.M.F.
Pemphigus foliaceus (PF) is an autoimmune bullous disease endemic in Brazil. Since serum IL-12 is increased in patients with PF and Langerhans cells (LC) produce IL-12, we titrated serum autoantibodies by indirect immunofluorescence, and quantified epidermal dendritic cells, known as LC, and dermal dendritic cells (DC). Biopsies of blistering lesions were obtained from 22 patients, 13 of whom were submitted to biopsy of both injured and of apparently healthy skin. The control groups consisted of skin from 8 cadavers and from 12 women submitted to breast plastic surgery. LC and DC were identified with anti-CD1a antibody and quantified by morphometric analysis. LC number in the lesion and in apparently healthy skin from PF patients was similar to that of...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Anti-CD1a; Dendritic cells; Fogo selvagem; Langerhans cells; Pemphigus foliaceus.
Ano: 2004
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2004000300008

Polymorphism of the promoter region and exon 1 of the CTLA4 gene in endemic pemphigus foliaceus (fogo selvagem)
Provedor de dados: 56
Autores: Pavoni,D.P.; Cerqueira,L.B.; Roxo,V.M.M.S.; Petzl-Erler,M.L.
Endemic pemphigus foliaceus (EPF) is an autoimmune bullous skin disease characterized by acantholysis and antibodies against a desmosomal protein, desmoglein 1. Genetic and environmental factors contribute to development of this multifactorial disease. HLA class II and some cytokine gene polymorphisms are the only genetic markers thus far known to be associated with susceptibility to or protection from EPF. The cytotoxic T-lymphocyte antigen-4 gene (CTLA4) encodes a key immunoreceptor molecule that regulates and inhibits T-cell proliferation. It participates in the regulatory process controlling autoreactivity and therefore has been considered a strong candidate gene in autoimmune diseases. In the search for genes that might influence EPF pathogenesis, we...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: CTLA4; Pemphigus; Fogo selvagem; Autoimmunity; Genetic susceptibility; Brazilian population.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2006000900010

Serum cytokines in patients with Brazilian pemphigus foliaceus (fogo selvagem)
Provedor de dados: 56
Autores: Zeoti,D.M.; Figueiredo,J.F.C.; Chiossi,M.P.V.; Roselino,A.M.F.
Pemphigus foliaceus (PF) is characterized by acantholysis determined by IgG4 binding to desmoglein I, a 160-kDa desmosomal glycoprotein. To investigate the immunopathological aspects of Brazilian PF, we determined levels of serum cytokines in patients with PF. Twenty-five patients with PF and a control group consisting of 10 healthy individuals were studied. Serum IL-2, IL-4, IL-5, IL-10, IL-12 and IFN-gamma were measured in the two groups by ELISA. The median concentration of IL-2 was lower in PF patients compared to the control group (0.45 and 9.50 pg/ml, respectively), as also was the concentration of IL-4 (0.26 and 10.16 pg/ml, respectively). The same was observed for IL-5 (7.94 and 15.74 pg/ml, respectively) and for IFN-gamma (5.90 and 8.58 pg/ml,...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Cytokines; Pemphigus; Pemphigus foliaceus; Fogo selvagem; Bullous dermatoses.
Ano: 2000
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000900012