Consulta: subjectFacets:"Forced swimming test"
Registros recuperados: 3
Data/hora: 08/06/2024 17:52:20

Antidepressant-like effect of Hoodia gordonii in a forced swimming test in mice: evidence for involvement of the monoaminergic system
Provedor de dados: 56
Autores: Citó,M.C.O.; Silva,M.I.G.; Santos,L.K.X.; Fernandes,M.L.; Melo,F.H.C.; Aguiar,J.A.C.; Lopes,I.S.; Sousa,P.B.; Vasconcelos,S.M.M.; Macêdo,D.S.; Sousa,F.C.F.
Hoodia gordonii is a plant species used traditionally in southern Africa to suppress appetite. Recently, it has been associated with a significant increase in blood pressure and pulse rate in women, suggesting sympathomimetic activity. The present study investigated the possible antidepressant-like effects of acute and repeated (15 days) administration of H. gordonii extract (25 and 50 mg/kg, po) to mice exposed to a forced swimming test (FST). Neurochemical analysis of brain monoamines was also carried out to determine the involvement of the monoaminergic system on these effects. Acute administration of H. gordonii decreased the immobility of mice in the FST without accompanying changes in general activity in the open-field test during acute treatment,...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Hoodia gordonii; Antidepressant action; Monoaminergic system; Forced swimming test.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2015000100057

Antidepressant-like effect of lead in adult mice
Provedor de dados: 56
Autores: Mantovani,M.; Matteussi,A.S.; Rodrigues,A.L.S.
It has been reported that lead can cause behavioral impairment by inhibiting the N-methyl-D-aspartate (NMDA) receptor complex. MK-801, a noncompetitive NMDA receptor antagonist, exhibits an antidepressant-like action in the forced swimming test. The purpose of the present study was to determine whether subacute lead exposure in adult male Swiss mice weighing 30-35 g causes an antidepressant-like action in a forced swimming test. Mice were injected intraperitoneally (ip) with 10 mg/kg lead acetate or saline daily for 7 consecutive days. Twenty-four hours after the last treatment, the saline and lead-treated mice received an injection of MK-801 (0.01 mg/kg, ip) or saline and were tested in forced swimming and in open-field tests. Immobility time was...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Lead acetate; Forced swimming test; Depression; Open-field.
Ano: 1999
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999001200017

Behavioral deficits in sepsis-surviving rats induced by cecal ligation and perforation
Provedor de dados: 56
Autores: Barichello,T.; Martins,M.R.; Reinke,A.; Constantino,L.S.; Machado,R.A.; Valvassori,S.S.; Moreira,J.C.F.; Quevedo,J.; Dal-Pizzol,F.
Sepsis and its complications are the leading causes of mortality in intensive care units, accounting for 10-50% of deaths. Intensive care unit survivors present long-term cognitive impairment, including alterations in memory, attention, concentration, and/or global loss of cognitive function. In the present study, we investigated behavioral alterations in sepsis-surviving rats. One hundred and ten male Wistar rats (3-4 months, 250-300 g) were submitted to cecal ligation and puncture (CLP), and 44 were submitted to sham operation. Forty-four rats (40%) survived after CLP, and all sham-operated animals survived and were used as control. Twenty animals of each group were used in the object recognition task (10 in short-term memory and 10 in long-term memory),...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Sepsis survivors; Recognition memory; Plus-maze test; Forced swimming test; Cecal ligation and puncture; Cognitive impairment.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007000600013