Consulta: subjectFacets:"GyrA"
Registros recuperados: 5
Data/hora: 16/06/2024 09:09:05

Antimicrobial Resistance in Campylobacter jejuni Isolated from Brazilian Poultry Slaughterhouses
Provedor de dados: 89
Autores: Paravisi,M; Laviniki,V; Bassani,J; Kunert Filho,HC; Carvalho,D; Wilsmann,DE; Borges,KA; Furian,TQ; Salle,CTP; Moraes,HLS; Nascimento,VP.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Antimicrobial resistance; Campylobacter jejuni; GyrA; Mutation; Poultry; TetO.
Ano: 2020
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-635X2020000200323

Mutations in the quinolone resistance-determining regions of gyrA and parC in Enterobacteriaceae isolates from Brazil
Provedor de dados: 58
Autores: Minarini,Luciene A. R.; Darini,Ana Lucia C.
Mutations in the quinolone resistance-determining regions (QRDR) in chromosomal gyrA and parC genes and fluoroquinolone susceptibility profiles were investigated in quinolone-resistant Enterobacteriaceae isolated from community and hospitalized patientsin the Brazilian Southeast region. A total of 112 nalidixic acid-resistant enterobacterial isolates collected from 2000 to 2005 were investigated for mutations in the topoisomerases genes gyrA and parC by amplifying and sequencing the QRDR regions. Susceptibility to fluoroquinolones was tested by the agar dilution method. Amongst the 112 enterobacterial isolates, 81 (72.3%) were resistant to ciprofloxacin and 5 (4.5%) showed reduced susceptibility. Twenty-six (23.2%) were susceptible to ciprofloxacin....
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Quinolone resistance-determining region; Mutations; GyrA; ParC; Enterobacteriaceae.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822012000400010

Quinolone resistance and ornithine decarboxylation activity in lactose-negative Escherichia coli
Provedor de dados: 58
Autores: Gomig,Franciane; Galvão,Carolina Weigert; Freitas,Denis Leandro de; Labas,Larissa; Etto,Rafael Mazer; Esmerino,Luiz Antonio; Lima,Marcelo Andrade de; Appel,Marcia Helena; Zanata,Silvio Marques; Steffens,Maria Berenice Reynaud; Nader,Helena Bonciani; Silveira,Rafael Bertoni da.
Quinolones and fluoroquinolones are widely used to treat uropathogenic Escherichia coli infections. Bacterial resistance to these antimicrobials primarily involves mutations in gyrA and parC genes. To date, no studies have examined the potential relationship between biochemical characteristics and quinolone resistance in uropathogenic E. coli strains. The present work analyzed the quinolone sensitivity and biochemical activities of fifty-eight lactose-negative uropathogenic E. coli strains. A high percentage of the isolates (48.3%) was found to be resistant to at least one of the tested quinolones, and DNA sequencing revealed quinolone resistant determining region gyrA and parC mutations in the multi-resistant isolates. Statistical analyses suggested that...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: ODC; GyrA; ParC; Uropathogenic.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822015000300753

Detection of quinolone-resistance mutations in Salmonella spp. strains of epidemic and poultry origin
Provedor de dados: 58
Autores: Souza,Roberta Barreiros de; Magnani,Marciane; Ferrari,Rafaela Gomes; Kottwitz,Luciana Bill Mikito; Sartori,Daniele; Tognim,Maria Cristina Bronharo; Oliveira,Tereza Cristina R. M. de.
Mutations into codons Aspartate-87 (62%) and Serine-83 (38%) in QRDR of gyrA were identified in 105 Salmonella strains resistant to nalidixic acid (94 epidemic and 11 of poultry origin). The results show a high incidence of mutations associated to quinolone resistance but suggest association with others mechanisms of resistance.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Quinolones; GyrA; Quinolone Resistance Determining Region (QRDR); AS-PCR-RFLP.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822011000100026

The role of gyrA and parC mutations in fluoroquinolones-resistant Pseudomonas aeruginosa isolates from Iran
Provedor de dados: 58
Autores: Nouri,Roghayeh; Ahangarzadeh Rezaee,Mohammad; Hasani,Alka; Aghazadeh,Mohammad; Asgharzadeh,Mohammad.
Abstract The aim of this study was to examine mutations in the quinolone-resistance-determining region (QRDR) of gyrA and parC genes in Pseudomonas aeruginosa isolates. A total of 100 clinical P. aeruginosa isolates were collected from different university-affiliated hospitals in Tabriz, Iran. Minimum inhibitory concentrations (MICs) of ciprofloxacin and levofloxacin were evaluated by agar dilution assay. DNA sequences of the QRDR of gyrA and parC were determined by the dideoxy chain termination method. Of the total 100 isolates, 64 were resistant to ciprofloxacin. No amino acid alterations were detected in gyrA or parC genes of the ciprofloxacin susceptible or ciprofloxacin intermediate isolates. Thr-83 → Ile substitution in gyrA was found in all 64...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Pseudomonas aeruginosa; Fluoroquinolone resistance; GyrA; ParC.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822016000400925