Consulta: subjectFacets:"Hematological malignancies"
Registros recuperados: 2
Data/hora: 10/06/2024 17:03:51

Involvement of transforming growth factor beta-1 (TGFβ1) cytokine and FOXP3 transcription factor genetic polymorphisms in hematological malignancies
Provedor de dados: Brazilian Archives of Biology and Technology
Autores: Vitiello,Glauco Akelinghton Freire; Guembarovski,Roberta Losi; Oliveira,Carlos Eduardo Coral de; Amarante,Marla Karine; Perim,Aparecida de Lourdes; Watanabe,Maria Angelica Ehara.
Hematological malignancies (HM) are a group of neoplastic diseases that arise from hematologic cell lineages. Transforming growth factor beta 1 (TGFβ1) is shown to negatively regulate normal and malignant hematopoiesis and, in immunological context, to promote T cell exhaustion and generation of regulatory T cells, which are shown to be deleterious in cancer, by the induction of transcription factor FOXP3 expression. The present study aimed to evaluate TGFB1 exon-1 rs1800470 and FOXP3 intron-1 rs2232365 polymorphisms in relation to HM susceptibility. DNA was extracted from blood samples of 43 HM patients and 142 neoplasia-free individuals and polymorphisms were analyzed by allelic-specific PCR. Association analysis was assessed by the Odds Ratio (OR) with...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Hematological malignancies; TGFB1; FOXP3; Genetic polymorphism; Susceptibility.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132015000400553

Invasive infection due to Saprochaete capitata in a young patient with hematological malignancies
Provedor de dados: Brazilian Journal of Microbiology
Autores: Parahym,Ana Maria Rabelo de Carvalho; Rolim Neto,Pedro José; Silva,Carolina Maria da; Domingos,Igor de Farias; Gonçalves,Sarah Santos; Leite,Edinalva Pereira; Morais,Vera Lúcia Lins de; Macêdo,Danielle Patrícia Cerqueira; Lima Neto,Reginaldo Gonçalves de; Neves,Rejane Pereira.
We report a case of invasive infection due to Saprochaete capitata in a patient with hematological malignancies after chemotherapy treatment and empiric antifungal therapy with caspofungin. Although severely immunocompromised the patient survived been treated with amphotericin B lipid complex associated with voriconazole.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Invasive infection; Saprochaete capitata; Geotrichum capitatum; Hematological malignancies; Antifungal susceptibility.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822015000200527