Consulta: subjectFacets:"Hepatitis B"
Registros recuperados: 38
Data/hora: 04/06/2024 07:55:33

Up-regulation of RIP1 and IPS-1 in chronic HBV infected patients
Provedor de dados: 74
Autores: Safari-Arababadi,Minoo; Modarressi,Mohammad Hossein; Arababadi,Mohammad Kazemi.
Abstract IPS-1 and RIP1 are the main downstream molecules of RIG1 and MDA5, as intracytoplasmic receptors, which are the main receptors involved in recognition of internal and external viral double-stranded RNA. In this project, mRNA levels of IPS-1 and RIP1 were investigated in the peripheral blood immune cells of chronic hepatitis B (CHB) patients. IPS-1 and RIP1 mRNA levels were measured in 60 CHB patients and 120 healthy subjects, using RT-qPCR technique. A significant increase in expression levels of IPS-1 and RIP1 was found in patients when compared to healthy individuals. There was no correlation between IPS-1 and RIP1expression levels with the serum levels of hepatitis B e-Antigen (HBeAg) and liver enzymes in patients. Based on the results, it...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Innate immunity; Hepatitis B; RIP1; IPS-1.
Ano: 2019
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572019000300337

Hepatitis B virus surface antigen seroconversion in HIV-infected individual after pegylated interferon-alpha treatment: a case report
Provedor de dados: 80
Autores: Delicio,Adriane Maira; Abati,Paulo Afonso Martins; Vigani,Aline Gonzalez.
Hepatitis B virus (HBV) infects from 6 to 14% of HIV-infected individuals. Concurrent HIV/HBV infection occurs due to the overlapping routes of transmission, particularly sexual and parenteral. HIV-infected patients that have acute hepatitis B have six times greater risk of developing chronic hepatitis B, with higher viral replication, rapid progression to end-stage liver disease and shorter survival. The coinfection is also associated with poor response to hepatitis B treatment with interferon-alpha and increased liver toxicity to the antiretroviral therapy. Herein, we describe the case of a 35-year-old man who engages in sex with men and presented with newly diagnosed HIV-1, serological markers for acute hepatitis B and progression to chronic hepatitis B...
Tipo: Info:eu-repo/semantics/report
Palavras-chave: HIV; Hepatitis B; HBsAg; Peginterferon.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992013000100503

Influencia del Aloe vera L. sobre la respuesta inmune humoral de ratones Balb/C inmunizados contra el virus de la hepatitis B
Provedor de dados: 98
Autores: Catellanos Puerto,Edelis; Mc Cook Noa,Leysis; n Mayor,Adriana; Vázquez González,Tatiana; Maceira,María Celia; Matos,Odalis.
Se realizó un estudio utilizando el extracto acuoso de Aloe vera L. para determinar su actividad inmunogénica en ratones Bal/C inmunizados con la vacuna recombinante contra hepatitis B (Herbiovac HB) de producción nacional. Específicamente se evaluó la latencia, la intensidad, la durabilidad y la memoria inmunológica a través de extracciones que se les hicieron en varios tiempos (3, 5, 27 semanas, 1 año y 15 días después de los 2 últimos tiempos); la muestra obtenida fue procesada mediante micro ELISA tipo sandwich para cuantificar anticuerpos contra el virus de la hepatitis B (anti HB). Se trabajó con 2 grupos de trabajo (control y tratamiento con Aloe) a los que se les inoculó por vía subcutánea solución salina y extracto acuoso inyectable de Aloe B M...
Tipo: Journal article
Palavras-chave: Adyuvante; Hepatitis B; HBs Ag; Aloe vera.
Ano: 2006
URL: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1028-47962006000300008

The challenge of the reference and counter-reference system in the prenatal assistance to pregnant women with infectious diseases
Provedor de dados: 42
Autores: Figueiredo,Elisabeth N.; Vianna,Lucila A. C.; Peixe,Marina B.; Ramos,Valdete M.; Succi,Regina C. M.
The objective of this study was to determine the prevalence of infectious diseases, such as syphilis, acquired immune deficiency syndrome (AIDS) and hepatitis B and C, in pregnant women who undertook their prenatal care in thirteen basic health units (BHU) in São Paulo city. The efficiency of the reference and counter-reference system in such prenatal infectious diseases was evaluated considering the medical recordings of the final result of the pregnancy and the vertical transmission rates of these diseases. It consists of an epidemiologic study whose observations were based on the notes of the prenatal medical and nurse records of pregnant women who had infectious diseases susceptible to vertical transmission and final infectious status registers of...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Congenital syphilis; Hepatitis B; Hepatitis C; HIV; Prenatal care; Referral and consultation.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652009000300018

Epidemiology of hepatitis B virus in the cities of the northern region of Espírito Santo, Brazil
Provedor de dados: 42
Autores: FONTES,ANDRÉ M.; ARDISSON,JULIANA S.; SOUZA,MARCO A.A.; FREITAS,RODRIGO R.; PANCOTO,JOÃO A.T.
ABSTRACT The World Health Organization (WHO) estimates that approximately 2 billion people worldwide have already had contact with hepatitis B virus (HBV) and 373 million have become chronic carriers. Hepatitis B is a major cause of chronic hepatitis, cirrhosis and hepatocellular carcinoma, leading to a large number of deaths annually. Both viral factors and the host immune response have been implicated in the pathogenesis and clinical result of HBV infection. Many Brazilian cities, including the cities of the northern region of the state of Espírito Santo are located in regions with little health infrastructure. Our study performed an epidemiological analysis of cases of Hepatitis B in São Mateus, using methodology of Geographic Information System (GIS),...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Hepatitis B; Epidemiology; Geoprocessing; Espírito Santo.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652016000401549

Prevalence of hepatitis B and C virus infections among military personnel
Provedor de dados: 55
Autores: Villar,Livia M.; Ó,Kycia Maria R. do; Scalioni,Leticia P.; Cruz,Helena M.; Portilho,Moyra M.; Mendonça,Ana Carolina F.; Miguel,Juliana C.; Figueiredo,Andreza S.; Almeida,Adilson J. de; Lampe,Elisabeth.
Background: Data regarding Hepatitis B and C viruses (HBV and HCV) prevalence among military personnel in Brazil are lacking, but the work-related risk of exposure can be high. The objective of this study was to estimate the seroprevalence of HBV and HCV and the risk factors associated to HBV exposure among Brazilian military personnel.Methods: A cross-sectional study was conducted and included 433 male military adults aged 18-25 years old working in Rio de Janeiro during October 2013. All individuals completed a questionnaire to assess their risk of exposure and provided a blood sample to HBV and HCV testing.Results: None of the participants presented HBsAg or anti-HBc IgM, 18 (4.1%) were positive for total anti-HBc, 247 (57.0%) were positive for...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Hepatitis B; Hepatitis C; Prevalence; Military personnel.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000300285

Comparison of entecavir and adefovir for the treatment of chronic hepatitis B
Provedor de dados: 55
Autores: Zhao,Si-Hai; Liu,En-Qi; Cheng,Da-Xin; Li,Ya-Feng; Wang,Yan-Li; Chen,Yu-Long; Sun,Wen-Tao; Yan,Xi-Cai; Dang,Shuang-Suo.
The results of several new clinical trials that compared the effectiveness of entecavir (ETV) treatment with that of adefovir (ADV) treatment in patients with chronic hepatitis B (CHB) were published in recent years. However, the numbers of patients included in these clinical trials were too small to draw a clear conclusion as to whether ETV is more effective than ADV. Therefore, a new meta-analysis was needed to compare ETV with ADV for the treatment of CHB. A search of the Cochrane Central Register of Controlled Trials (CCTR), MEDLINE, the Science Citation Index, Embase, the China National Knowledge Infrastructure (CNKI), and the Wanfang Database for relevant studies published between 1966 and 2010 was performed. Trials comparing the use of ETV and ADV...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Entecavir; Adefovir; Hepatitis B.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000400010

Transfusion risk for hepatitis B, hepatitis C and HIV in the state of Santa Catarina, Brazil, 1991-2001
Provedor de dados: 55
Autores: Kupek,Emil.
We examined the time trend of residual risk of transfusing blood contaminated with HIV, hepatitis B and hepatitis C, in the largest blood bank of the state of Santa Catarina, Brazil, 1991-2001. The HIV risk was reduced approximately 10 times during the decade of 1990, to 1:48777, but then increased significantly by the end of 2001. A similar time trend was observed for hepatitis B and hepatitis C, although the increase was not significant in this case. Even during the period of lowest risk, the estimates were considerably higher than in developed countries.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Blood transfusion; HIV; Hepatitis B; Hepatitis C.
Ano: 2004
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702004000300007

Cost-effectiveness of telbivudine versus lamivudine for chronic hepatitis B
Provedor de dados: 55
Autores: Wiens,Astrid; Venson,Rafael; Correr,Cassyano Januário; Pontarolo,Roberto.
BACKGROUND AND AIM: Chronic hepatitis B is a highly prevalent disease worldwide, leading to serious consequences if not properly treated. Six treatment options for chronic hepatitis B are currently provided by the Brazilian public health system. Telbivudine is a nucleoside analogue that is neither included in the Brazilian clinical protocol nor in the therapeutic guidelines for chronic hepatitis B. OBJECTIVE: The aim of this study was to evaluate the cost-effectiveness of telbivudine for the viewpoint of the Brazilian public system, comparing it to lamivudine. METHODS: A Markov model was used to project lifetime complications and costs of treatment with lamivudine or telbivudine for chronic hepatitis B in both HBeAg-positive and HBeAg-negative patients. To...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Lamivudine; Cost-effectiveness evaluation; Hepatitis B; Chronic.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000300008

Seroprevalence of hepatitis B and C in the Western Brazilian Amazon region (Rio Branco, Acre): a pilot study carried out during a hepatitis B vaccination program
Provedor de dados: 55
Autores: Tavares-Neto,J.; Almeida,D.; Soares,M. C.; Uchoa,R.; Viana,S.; Darub,R.; Farias,E.; Rocha,G.; Vitvitski,L.; Paraná,R.
In 1999, on the occasion of the application of the first vaccine dose during the state vaccination campaign against hepatitis B virus (HBV), 390 individuals from the town of Rio Branco, Acre, aged two or more years were selected for the determination of the seroprevalence of HBV and HCV. HBV markers (HBsAg, anti-HBs, and anti-HBc IgG) were determined on this occasion and anti-HBs antibodies were also assessed 30 days after the third vaccine dose. At the time of vaccination, 39% of the individuals were still susceptible to HBV, while 61% presented serologic evidence of previous HBV contact or previous vaccination. The individuals with previous HBV contact were significantly older (p&lt;0.001) than those without HBV markers. Of the 192 individuals who...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Hepatitis B vaccination; Amazonia; Hepatitis B; Hepatitis C; Epidemiology.
Ano: 2004
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702004000200003

Transgenic lettuce seedlings carrying hepatitis B virus antigen HBsAg
Provedor de dados: 55
Autores: Marcondes,Jackson; Hansen,Ekkehard.
The obtainment of transgenic edible plants carrying recombinant antigens is a desired issue in search for economic alternatives viewing vaccine production. Here we report a strategy for genetic transformation of lettuce plants (Lactuca sativa L.) using the surface antigen HBsAg of hepatitis B virus. Transgenic lettuce seedlings were obtained through the application of a regulated balance of plant growth regulators. Genetic transformation process was acquired by cocultivation of cotyledons with Agrobacterium tumefaciens harboring the recombinant plasmid. It is the first description of a lettuce Brazilian variety "Vitória de Verão" genetically modified.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Edible vaccine; Hepatitis B; Oral immunization; Recombinant antigen; Transgenic plants.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000600004

Identification of hepatitis B virus A1762T/G1764A double mutant strain in patients in Southern Brazil
Provedor de dados: 55
Autores: Silva Souza,Adaliany Cecília da; Souza Marasca,Giórgia de; Kretzmann-Filho,Nélson Alexandre; Dall-Bello,Aline; Kliemann,Dimas Alexandre; Tovo,Cristiane Valle; Veiga,Ana Beatriz Gorini da.
Abstract Infection by hepatitis B virus (HBV) is a worldwide public health problem. Chronic HBV infection with high viral replication may lead to cirrhosis and/or hepatocellular carcinoma. Mutant HBV strains, such as the HBV A1762T/G1764A double mutant, have been associated with poor prognosis and higher risk of the patient for developing cirrhosis and/or hepatocellular carcinoma. This study analyzed the presence of the HBV A1762T/G1764A double mutant in patients with chronic HBV and its association with clinical parameters such as viral load, aminotransferases, and HBV antigens. A total of 49 patients with chronic hepatitis B were included in the study, and the HBV A1762T/G1764A double mutant strain was detected in four samples (8.16%) by polymerase chain...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Hepatitis B; HBV; A1762T/G1764A mutation.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000500525

Acute exacerbation of chronic hepatitis B virus infection in renal transplant patients
Provedor de dados: 55
Autores: Emori,Christini Takemi; Perez,Renata Melo; Matos,Carla Adriana Loureiro de; Uehara,Silvia Naomi Oliveira; Pereira,Patricia da Silva Fucuta; Feldner,Ana Cristina Amaral; Carvalho Filho,Roberto José de; Silva,Ivonete Sandra de Souza e; Silva,Antonio Eduardo Benedito; Ferraz,Maria Lucia Gomes.
Introduction:There is scarce information regarding clinical evolution of HBV infection in renal transplant patients.Aims:To evaluate the prevalence of acute exacerbation in HBV-infected renal transplant patients and its association with the time after transplantation, presence of viral replication, clinical evolution, and use of antiviral prophylaxis.Materials and methods:HBV infected renal transplant patients who underwent regular follow-up visits at 6-month intervals were included in the study. The criteria adopted to characterize exacerbation were: ALT &gt;5 × ULN and/or &gt;3 × baseline level. Predictive factors of exacerbation evaluated were age, gender, time on dialysis, type of donor, post-transplant time, ALT, HBeAg, HBV-DNA, HCV-RNA,...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Renal transplantation; Hepatitis B; ALT flare; Lamivudine.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000600625

Hepatitis B in healthcare workers: prevalence, vaccination and relation to occupational factors
Provedor de dados: 55
Autores: Ciorlia,Luiz A.S.; Zanetta,Dirce M.T.
The prevalence of hepatitis B virus (HBV) in healthcare workers (HCW) in Brazilian university hospitals is high. However, vaccination of these workers and relations with occupational factors are not well documented. A prospective study was made of 1,433 HCW and 872 administrative employees of the Hospital de Base (HB), São José do Rio Preto, SP, Brazil, and 2,583 blood donor candidates from the Hospital Blood Bank. HCW were observed from January 1994 to December 1999. Data were obtained from exams made when a worker entered hospital service, periodically and after work-related injuries. Serological reactions were analyzed in HCW who received HBV vaccine. Occupational and non-occupational information was obtained through a questionnaire. The prevalence of...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Hepatitis B; Healthcare workers; Prevalence; Vaccination; Occupational injuries.
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702005000500005

Leprosy and hepatitis B coinfection in southern Brazil
Provedor de dados: 55
Autores: Leitão,Cleverson; Ueda,Denis; de Moraes Braga,Anna Carolina; Boldt,Angelica B.W.; Messias-Reason,Iara J.T.
To investigate the association of leprosy with hepatitis B virus (HBV) infection, as yet unknown for South Brazil, we assessed hepatitis B virus coinfection in 199 South Brazilian leprosy patients (119 lepromatous, 15 tuberculoid, 30 borderline, 12 undetermined and 23 unspecified) and in 681 matched blood donors by screening for the hepatitis B virus markers HBSAg and anti-HBc, using ELISA. Positive samples were retested and anti-HBc+ only samples were tested for the hepatitis B surface antibody (anti-HBs). There was a strong association between leprosy and hepatitis B virus infection (OR = 9.8, 95% CI = 6.4–14.7; p = 0.004·E−30), as well as an association between HBV infection and lepromatous leprosy, compared to other forms (OR = 2.4, 95% CI = 1.2–4.8; p...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Leprosy; Hepatitis B; Leprosarium; HBV; Mycobacterium leprae.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000100008

Absence of occult hepatitis B among blood donors in southern Brazil
Provedor de dados: 55
Autores: Wolff,Fernando Herz; Fuchs,Sandra Costa; Brandão,Ajacio BM.
BACKGROUND: Occult hepatitis B virus (HBV) infection is characterized by the detection of HBV DNA in serum and/or in liver in the absence of detectable hepatitis B surface antigen (HBsAg). The reported prevalence of occult hepatitis B varies markedly among populations and according to the sensitivity of the HBV DNA assay. The aim of the present study was to describe the prevalence of occult hepatitis B among HCV-infected and non-infected blood donors in Porto Alegre, Southern Brazil, using a highly sensitive real time polymerase chain reaction (PCR) method. METHODOLOGY: Between 1995 and 1997 a sample of 178 blood donors with two positive anti-HCV ELISA tests were consecutively selected as cases, and 356 anti-HCV negative donors were selected as controls....
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Hepatitis B; Hepatitis B virus; Blood donors; Seroepidemiologic studies.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000200012

Retrospective analysis of hepatitis B virus chronic infection in 247 patients: clinical stages, response to treatment and poor prognostic factors
Provedor de dados: 55
Autores: Cunha-Silva,Marlone; Marinho,Fábio R.T.; Oliveira,Paulo F.; Lopes,Tirzah M.; Sevá-Pereira,Tiago; Lorena,Sonia L.S.; Almeida,Jazon R.S.
Abstract  Background: Chronic hepatitis B is a major cause of cirrhosis, and the natural history of the disease has several clinical stages that should be thoroughly understood for the implementation of proper treatment. Nonetheless, curing the disease with antiviral treatment remains a challenge.  Aims: To describe the clinical course, response to treatment, and poor prognostic factors in 247 hepatitis B virus chronic infection patients treated in a tertiary hospital in Brazil.  Methods: This was a retrospective and observational study, by analyzing the medical records of HBV infected patients between January 2000 and January 2015.  Results: Most patients were male (67.2%) and 74.1% were HBeAg negative. Approximately 41% had cirrhosis and 8.5% were...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Hepatitis B; Clinical stages; Treatment; Liver cirrhosis; Hepatocellular carcinoma.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000400441

Double-dose hepatitis B vaccination in cirrhotic patients on a liver transplant waiting list
Provedor de dados: 55
Autores: Bonazzi,Patricia R.; Bacchella,Telesforo; Freitas,Angela C.; Osaki,Karina T.; Lopes,Marta H.; Freire,Maristela P.; Machado,Marcel C.C.; Abdala,Edson.
Development of immunity to hepatitis B virus in cirrhotic patients waiting for liver transplantation is highly desirable. Though a double-dose regimen is available, little is know about its effectiveness. We examined the efficacy of double-dose hepatitis B virus vaccination in cirrhotic patients waiting for liver transplantation. We studied 43 patients who were waiting for liver transplantation. They were vaccinated with three doses of 40 mg hepatitis B vaccine at 0, 1 and 6 months; the normal dose is 20 mg. Efficacy was measured based on seroconversion of anti-HBs. Global response to the primary vaccination scheme was 67.5% (29 patients). Forty-one per cent of responders had anti-HBs titers above 1,000 IU/mL. No factors were associated with response,...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Vaccine; Cirrhotic; Hepatitis B; Liver transplant.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000400009

Seroprevalence of HbsAg, anti-HBc and anti-HCV in Southern Brazil, 1999-2001
Provedor de dados: 55
Autores: Rosini,Nilton; Mousse,Donaida; Spada,Celso; Treitinger,Arício.
The prevalence of infection by the hepatitis B (HBV) and C (HCV) viruses varies among geographical regions. We evaluated 263,795 blood donor samples collected from 1999-2001 in various cities in the state of Santa Catarina to determine the prevalence of HbsAg, anti-HBc and anti-HCV markers. The markers were analyzed by immunoenzymatic tests, as determined by the Ministry of Health, and the data were obtained from blood banks and from ANVISA (the Brazilian National Agency for Sanitary Vigilance). There was a significant reduction in the mean frequency of HbsAg and anti-HBc during the study period, from 0.98% to 0.64% and from 8.83% to 5.35%, respectively, though they varied considerably among the different regions. There was also a decrease in the mean...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Blood donors; Hepatitis B; Hepatitis C; HbsAg; Anti-HBc; Anti-HCV.
Ano: 2003
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702003000400006

Vaccination coverage and immunity against hepatitis B among HIV-infected patients in South Brazil
Provedor de dados: 55
Autores: Martins,Saulo; Livramento,Andréa do; Andrigueti,Michelle; Kretzer,Iara Fabricia; Machado,Marcos José; Spada,Celso; Treitinger,Arício.
Evidence-based strategies to improve the hepatitis B virus (HBV) vaccination coverage rates might help to reduce the burden caused by co-infection with HBV and human immuno-deﬁciency virus (HIV). In this study, the aim was to evaluate the vaccination coverage and immunity against HBV among HIV-infected individuals in South Brazil, and identify factors that are associated with compliance patterns and antibody reactivity. Three hundred HIV-infected men and women were included in this survey. The patients answered a standardized questionnaire, and vaccination cards were checked in order to assess hepatitis B vaccine status. A blood sample was collected for quantitative determination of antibody to hepatitis B virus surface antigen (anti-HBs). Participants...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; Hepatitis B; HBV Vaccination; Immunity.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000200181

Role of hyaluronic acid and laminin as serum markers for predicting significant fibrosis in patients with chronic hepatitis B
Provedor de dados: 55
Autores: Li,Feng; Zhu,Chang-Lai; Zhang,Hong; Huang,Hua; Wei,Qun; Zhu,Xiang; Cheng,Xiao-Yang.
OBJECTIVES: The aim of this study was to evaluate the diagnostic performance of serum HA and LN as serum markers for predicting significant fibrosis in CHB patients. METHODS: Serum HA and LN levels of 87 patients with chronic hepatitis B and 19 blood donors were assayed by RIA. Liver fibrosis stages were determined according to the Metavir scoring-system. The diagnostic performances of all indexes were evaluated by the receiver operating characteristic (ROC) curves. RESULTS: Serum HA and LN concentrations increased significantly with the stage of hepatic fibrosis, which showed positive correlation with the stages of liver fibrosis (HA: r = 0.875, p &lt; 0.001; LN: r = 0.610, p &lt; 0.001). There were significant differences of serum HA and LN levels...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Hepatitis B; Chronic Hyaluronic acid Laminin Liver Cirrhosis ROC curve.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000100002

Human immunodeficiency virus and hepatitis C virus/hepatitis B virus co-infection in Southern Brazil: clinical and epidemiological evaluation
Provedor de dados: 55
Autores: Raboni,Sonia Mara; Tuon,Felipe Francisco; Beloto,Nayara Carvalho Polido; Demeneck,Henrique; Oliveira,Andre; Largura,Denis; Sagrado,Andressa Gervasoni; Lima,Bárbara Perdonsini; Franzoni,João Paulo; Pedroso,Maria Lucia.
Hepatitis B virus, hepatitis C virus and human immunodeficiency virus share a similar transmission pathway and are often diagnosed in the same patient. These patients tend to have a faster progression of hepatic fibrosis. This cross-sectional study describes the demographic features and clinical profile of human immunodeficiency virus/hepatitis co-infected patients in Parana, Southern Brazil. A total of 93 human immunodeficiency virus-infected patients attending a tertiary care academic hospital in Southern Brazil were included. Clinical, demographic and epidemiological data were evaluated. Hepatitis B virus and/or hepatitis C virus positive serology was found in 6.6% of patients. The anti-hepatitis C virus serum test was positive in 85% (79/93) of...
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Human immunodeficiency virus; Hepatitis B; Hepatitis C; Co-infection.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000600664

Serological markers of hepatitis A, B and C viruses in rural communities of the semiarid Brazilian Northeast
Provedor de dados: 55
Autores: Almeida,Delvone; Tavares-Neto,José; Vitvitski,Ludmila; Almeida,Alessandro; Mello,Caroline; Santana,Diana; Tatsch,Fernando; Paraná,Raymundo.
In the village of Cavunge, located in a dry tropical, semiarid rural region of the state of Bahia, Brazil, a sentinel study on viral hepatitis is underway. We report on the first part of the study. The objective of this study was to determine the prevalence of serological markers for hepatitis A, B and C in the village. Cross sectional study. Blood samples were tested for serological markers of hepatitis A (HAV), B (HBV) and C (HCV) through ELISA-III assay. In HBsAg and anti-HCV carriers, HCV-RNA and HBV-DNA were checked by PCR. The prevalence of anti-HAV IgG was 83.3% (1,210/1,452), being higher among residents from the village (87.4%) than in residents from the rural area (79.5%); it also higher among individuals older than 10 years of age. The...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Hepatitis A; Hepatitis B; Hepatitis C; Epidemiology; Brazil.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000500003

Simultaneous detection of hepatitis B virus genotypes and mutations associated with resistance to lamivudine, adefovir, and telbivudine by the polymerase chain reaction-ligase detection reaction
Provedor de dados: 55
Autores: Wang,Yong-Zhong; Xiao,Jun-Hua; Liu,Long-Gen; Ye,Chun-Yan; Shen,Hong-Yu; Xu,Tian-Min; Zhu,Ke-Zhuan.
OBJECTIVES: Detection of mutations associated to nucleos(t)ide analogs and hepatitis B virus (HBV) genotyping are essential for monitoring treatment of HBV infection. We developed a multiplex polymerase chain reaction-ligase detection reaction (PCR-LDR) assay for the rapid detection of HBV genotypes and mutations associated with lamivudine, adefovir, and telbivudine resistance in HBV-infected patients. METHODS: HBV templates were amplified by PCR, followed by LDR and electrophoresis on a sequencer. The assay was evaluated using plasmids that contained wild-type or mutant HBV sequences and 216 clinical samples. RESULTS: The PCR-LDR assay and sequencing gave comparable results for 158 of the 216 samples (73.1%) with respect to mutation detection and...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Hepatitis B; Drug resistance; Mutation; Genotype.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000600010

Hepatitis B virus genotyping in chronic hepatitis B patients in southwestern Saudi Arabia
Provedor de dados: 55
Autores: Asaad,Ahmed Morad; Al-Ayed,Mohamed Saeed Zayed; Aleraky,Mohamed; Qureshi,Mohamed Ansar.
ABSTRACTThe distribution of hepatitis B virus genotypes in Saudi Arabia is largely unknown. To the best of our knowledge there are no data available about HBV genotypes in southwestern region of the country. This study aimed to determine the epidemiologic distribution of hepatitis B virus genotypes in chronic hepatitis B patients in southwestern region, and to verify possible correlations between these genotypes and the clinical symptoms. A total of 160 patients with chronic hepatitis B infection were enrolled in this study. Sera were tested for liver function tests, hepatitis B virus markers and DNA load by standard procedures. HBV genotyping was performed by 2-tube nested PCR for determination of six genotypes (A-F). Genotype D was the most common, found...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Hepatitis B; HBV genotypes; Genotype D; Najran.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000500525

The effectiveness of the national hepatitis B vaccination program 25 years after its introduction in Iran: a historical cohort study
Provedor de dados: 55
Autores: Moghadami,Mohsen; Dadashpour,Nazanin; Mokhtari,Ali Mohammad; Ebrahimi,Mostafa; Mirahmadizadeh,Alireza.
ABSTRACT  Introduction: Hepatitis B virus (HBV) is responsible for one of the most common human viral infections. An estimated 257 million people are living with chronic HBV infection worldwide, and mortality has reached 900,000 deaths in recent years. In 2001, the World Health Organization reported a prevalence of chronic hepatitis B infection in Iran between 2-7%.  Objective: To assess the effect of the national HBV mass vaccination program after 25 years.  Methods: A retrospective cohort study was conducted in vaccinated and unvaccinated people according to the year of birth. Blood samples were obtained from each enrolled person and data about demographic variables, and medical and vaccination history were collected using a standardized questionnaire....
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Hepatitis B; Vaccination; Effectiveness research.
Ano: 2019
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000600419

Prevalence of hepatitis B among pregnant women assisted at the public maternity hospitals of São Luís, Maranhão, Brazil
Provedor de dados: 55
Autores: Souza,Marinilde Teles; Pinho,Tainá Lima Reis de; Santos,Max Diego Cruz; Santos,Alexsandro dos; Monteiro,Vera Lúcia; Fonsêca,Lena Maria Barros; Ferreira,Pedro Antônio Muniz; Ferreira,Adalgisa de Souza Paiva.
INTRODUCTION: Hepatitis B virus (HBV) infection is an important worldwide public health problem. In Brazil, the Ministry of Health estimates that 15% of the population has had contact with HBV, and that the mean rate of chronic carriers in Northeastern Brazil is around 0.5%. OBJECTIVE: The aim of this study was to assess the prevalence of HBV markers in pregnant women receiving prenatal care at the public maternity hospitals of São Luís. Methods: Demographical and epidemiological data were collected from 541 pregnant women according to the research protocol. Blood samples were collected, and the anti-HBc test was performed first. If positive, the sample was subsequently tested for HBsAg and anti-HBs. All HBsAg and/or anti-HBc positive samples were...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Pregnant; Hepatitis B; HBV-DNA.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000600003

Response predictors to treatment with pegylated interferon in chronic hepatitis B
Provedor de dados: 55
Autores: Ferreira,Paulo Roberto Abrão; Tenore,Simone de Barros.
The clinical and epidemiological importance of chronic B hepatitis is currently unquestionable as a cause of end-stage liver disease and hepatocellular carcinoma. Recently, predictors of treatment response of this disease have been studied, both before and during the course of medication. Therapy stopping rules have been proposed, which may be useful in patients presenting poor treatment tolerance. This review discusses the treatment response predictors usefulness, with emphasis on ALT, quantitative HBsAg and HBeAg, quantitative HBV-DNA and HBV genotype
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Hepatitis B; HBsAg; HBeAg; HBV-DNA; Pegylated interferon.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000500017

Hepatitis B virus genotype E detected in Brazil in an African patient who is a frequent traveler
Provedor de dados: 56
Autores: Sitnik,R; Sette Jr,H; Santana,R.A.F; Menezes,L.C; Graça,C.H.N; Dastoli,G.T.F; Silbert,S; Pinho,J.R.R.
Genotype E of hepatitis B virus (HBV) has not been described in Brazil and is found mainly in Africa. Genotype A is the most prevalent in Brazil, and genotypes B, C, D, and F have already been reported. We report here an HBV genotype E-infected patient and some characterization of surface (S) protein, DNA polymerase (P) and precore/core (preC/C) coding regions based on the viral genome. The patient is a 31-year-old black man with chronic hepatitis B who was born and raised in Angola. He has been followed by a hepatologist in São Paulo, Brazil, since November 2003, and he is a frequent traveler to Latin America, Africa, and Europe. In 2003, he was diagnosed with HBV infection and started treatment with lamivudine with the later addition of adefovir...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Hepatitis B; HBV genotype E; Precore mutation; Brazil; Africa; African traveler.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007001200013

A prospective study of hepatitis B virus markers in patients with chronic HBV infection from Brazilian families of Western and Asian origin
Provedor de dados: 56
Autores: Carrilho,F.J.; Ono-Nita,S.K.; Cardoso,R.A.; Cancado,E.L.R.; Pinho,J.R.R.; Alves,V.A.F.; Da Silva,L.C.
The purpose of the present study was to determine the frequency of hepatitis B virus (HBV) markers in families of HBsAg-positive patients with chronic liver disease. Serum anti-HBc, HBsAg and anti-HBs were determined by enzyme immunoassay and four subpopulations were considered: genetically related (consanguineous) and non-genetically related (non-consanguineous) Asian subjects and genetically related and non-genetically related Western subjects. A total of 165 and 186 relatives of Asian and Western origin were enrolled, respectively. The occurrence of HBsAg and anti-HBs antibodies was significantly higher (P &lt; 0.0001) in family members of Asian origin (81.8%) than in family members of Western origin (36.5%). HBsAg was also more frequent among brothers...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Hepatitis B; Familial clustering; HBsAg; Vertical transmission; Anti-HBc; Anti-HBs.
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005000900015

The emergence of YMDD mutants precedes biochemical flare by 19 weeks in lamivudine-treated chronic hepatitis B patients: an opportunity for therapy reevaluation
Provedor de dados: 56
Autores: França,P.H.C.; Coelho,H.S.M.; Brandão,C.E.; Segadas,J.A.; Quintaes,R.F.; Carrilho,F.J.; Ono-Nita,S.; Mattos,A.A.; Tovo,C.; Gouvea,V.S.; Sablon,E.; Vanderborght,B.O.M.
Given the loss of therapeutic efficacy associated with the development of resistance to lamivudine (LMV) and the availability of new alternative treatments for chronic hepatitis B patients, early detection of viral genotypic resistance could allow the clinician to consider therapy modification before viral breakthrough and biochemical relapse occur. To this end, 28 LMV-treated patients (44 ± 12 years; 24 men), on their first therapy schedule, were monitored monthly at four Brazilian centers for the emergence of drug resistance using the reverse hybridization-based INNO-LiPA HBV DR assay and occasionally sequencing (two cases). Positive viral responses (HBV DNA clearance) after 6, 12, and 18 months of therapy were achieved by 57, 68, and 53% of patients,...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Hepatitis B; Antiviral therapy; Lamivudine; Drug resistance; YMDD variants; Hepatitis B virus.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007001200003

Role of p53 codon 72 polymorphism in chromosomal aberrations and mitotic index in patients with chronic hepatitis B
Provedor de dados: 56
Autores: Akbaş,H.; Yalcin,K.; Isi,H.; Tekes,S.; Atay,A.E.; Akkus,Z.; Budak,T.
Polymorphisms of the p53 gene, which participates in DNA repair, can affect the functioning of the p53 protein. The Arg and Pro variants in p53 codon 72 were shown to have different regulation properties of p53-dependent DNA repair target genes that can affect various levels of cytogenetic aberrations in chronic hepatitis B patients. The present study aimed to examine the frequency of chromosomal aberrations and the mitotic index in patients with chronic hepatitis B and their possible association with p53 gene exon 4 codon 72 Arg72Pro (Ex4+119 G&gt;C; rs1042522) polymorphism. Fifty-eight patients with chronic hepatitis B and 30 healthy individuals were genotyped in terms of the p53 gene codon 72 Arg72Pro polymorphism by PCR-RFLP. A 72-h cell culture was...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Hepatitis B; Chromosomal aberrations; Mitotic index; P53 gene codon 72 polymorphism.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012001100003

Risk of hepatitis B virus transmission by diagnostic hysteroscopy
Provedor de dados: 56
Autores: Santos,N.C.; Pinho,J.R.R.; Lemos,M.F.; Moreira,R.C.; Lopes,C.M.C.; Sacilotto,M.T.J.; Tacla,M.; Pinheiro,W.S.; Ramos,L.O.
Few data are available in the literature concerning the efficacy of standard hysteroscope disinfection procedures to prevent hepatitis B transmission. The aim of the present study was to determine the risk of hepatitis B virus (HBV) transmission during hysteroscopy among anti-HBc-seropositive women. Serum and hysteroscopic samples were collected from 62 women after diagnostic hysteroscopy. All samples were tested for serologic HBV markers. Polymerase chain reactions (PCR) were carried out to amplify regions C and S of the viral genome and only samples amplified by both pairs of primers were considered to be positive. Anti-HBc was repeatedly reactive in 48 (77%) of 62 serum samples, and HBsAg was detected in 8 (13%). At least one HBV serologic marker was...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Hepatitis B; Hysteroscopy; Disinfection; Polymerase chain reaction.
Ano: 2004
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2004000500009

Lamivudine therapy for hepatitis B in renal transplantation
Provedor de dados: 56
Autores: Santos,F.R.L.; Haiashi,A.R.; Araújo,M.R.T.; Abensur,H.; Romão Junior,J.E.; Noronha,I.L.
Antiviral therapies are associated with an increased risk of acute rejection in transplant patients. The aim of the present study was to evaluate the efficacy and safety of lamivudine therapy for hepatitis B virus (HBV) infection in renal transplant patients. Six patients were included in this study. They received 150 mg/day of lamivudine during a follow-up period of 24 months. The laboratory tests monitored were HBV DNA, HBsAg, HBeAg, ALT, gamma-GT, serum creatinine and blood cyclosporine levels. The HBV DNA became undetectable in four patients as early as in the third month of treatment. After six months, the viral load was also negative in the other two patients, and remained so until 18 months of follow-up. The medication was well tolerated with no...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Lamivudine; Kidney transplantation; Hepatitis B.
Ano: 2002
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002000200008

Serological markers and risk factors related to hepatitis B virus in dentists in the Central West region of Brazil
Provedor de dados: 58
Autores: Paiva,Enilza Maria Mendonça de; Tiplle,Anaclara Ferreira Veiga; Silva,Eliane de Paiva e; Cardoso,Divina das Dores de Paula.
The hepatitis B virus (HBV) has been considered the major occupational risk agent for dentists. The Central West region of Brazil is considered an intermediate endemic pattern area, but currently there is no information about the HBV prevalence in dentists of Goiânia, Goiás. This study aimed at the detection of the HBV infection rate and risk factors for dentists of Goiânia and the comparison of the obtained data with the general population and other groups. A randomized sample of 680 professionals participated in this study. All dentists gave written consent for the procedure and filled out a questionnaire about risk factors. The HBV serological markers were analyzed using ELISA test and the presence of anti-HBc was observed in 41 (6.0%) of the dentists....
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HBV; Dentists; Hepatitis B.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822008000200010

In-house quantitative real-time PCR for the diagnosis of hepatitis B virus and hepatitis C virus infections
Provedor de dados: 58
Autores: Zauli,Danielle Alves Gomes; Menezes,Carla Lisandre Paula de; Oliveira,Cristiane Lommez de; Mateo,Elvis Cristian Cueva; Ferreira,Alessandro Clayton de Souza.
Abstract The quantification of viral nucleic acids in serum by real-time PCR plays an important role in diagnosing hepatitis B virus and hepatitis C virus infection. In this study, we developed an assay using specific primers and probes to quantify hepatitis B virus DNA or hepatitis C virus RNA in serum from infected patients. For standardization and validation of the assay, an international panel of hepatitis B virus/hepatitis C virus and standard plasmids was used. A correlation coefficient of 0.983 and 0.963 for hepatitis B virus and hepatitis C virus, respectively, was obtained based on cycle threshold values and concentrations of DNA or RNA. The standard curve showed a linear relationship from 19 IU/mL to 1.9 × 109 IU/mL of serum, with a coefficient...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: QPCR; Hepatitis B; Hepatitis C.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822016000400987

Aflatoxin M1 in the urine of non-carriers and chronic carriers of hepatitis B virus in Maringa, Brazil
Provedor de dados: 60
Autores: Giolo,Marcel Padovani; Oliveira,Christiane Minervino de; Bertolini,Dennis Armando; Lonardoni,Maria Valdrinez Campana; Gouveia,Matheus Sampaio; Netto,Daisy Pontes; Nixdorf,Suzana Lucy; Machinski Junior,Miguel.
Exposure to aflatoxins (AFs) in the diet may favour the development of hepatocellular carcinoma (HCC) and the acute exacerbation of hepatitis in chronic hepatitis B virus (HBV) carriers. Measurement of biomarkers such as aflatoxin M1 (AFM1), a metabolite of aflatoxin B1 (AFB1), in urine allows for the assessment of populations exposed to aflatoxins. The aim of this study was to investigate the occurrence of aflatoxin M1 in the urine of HBV carrier and non-carrier patients. One group included 43 randomly selected HBV carriers treated at two hospitals in the city of Maringa, Brazil, from March to June 2008. Control group consisted of 29 healthy adult volunteers with anti-HBs positive and HBsAg negative test results. Detection of AFM1 was performed by...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Aflatoxins; Biomarkers; Hepatitis B; Hepatocellular carcinoma; Urina/análise toxicológica; Epidemiology.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502012000300011

Seroprevalence of HBV and HCV markers among young adult males in the Air Force in Florianópolis, South Brazil
Provedor de dados: 60
Autores: Passos,Ana Maria; Strazer Neto,Miguel; Treitinger,Aricio; Spada,Celso.
We investigated the prevalence of hepatitis B virus (HBV) and hepatitis C virus (HCV) serological markers of infection in young adults from the metropolitan region of Florianópolis who were conscripts of the Air Base of Florianópolis in the state of Santa Catarina, Brazil. A population-based cross-sectional seroprevalence study was conducted with 371 young males during a one year period starting in June 2009. Demographic characteristics, socio-economic characteristics and possible risk factors to HBV and HCV were assessed. Blood samples were analyzed for HBsAg, anti-HBc, anti-HCV and anti-HBs through automated microparticle enzymatic immunoassays (Abbott®, AxSYM System, Wiesbaden, Germany). None of the participants showed positivity to HBsAg or anti-HCV....
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HBV; HCV; Hepatitis B; Hepatitis C; Seroprevalence.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502012000200009