Consulta: subjectFacets:"Hereditary cancer"
Registros recuperados: 4
Data/hora: 10/06/2024 18:24:38

Costs of genetic testing: Supporting Brazilian Public Policies for the incorporating of molecular diagnostic technologies
Provedor de dados: 74
Autores: Schlatter,Rosane Paixão; Matte,Ursula; Polanczyk,Carisi Anne; Koehler-Santos,Patrícia; Ashton-Prolla,Patricia.
This study identifies and describes the operating costs associated with the molecular diagnosis of diseases, such as hereditary cancer. To approximate the costs associated with these tests, data informed by Standard Operating Procedures for various techniques was collected from hospital software and a survey of market prices. Costs were established for four scenarios of capacity utilization to represent the possibility of suboptimal use in research laboratories. Cost description was based on a single site. The results show that only one technique was not impacted by rising costs due to underutilized capacity. Several common techniques were considerably more expensive at 30% capacity, including polymerase chain reaction (180%), microsatellite instability...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Molecular diagnosis; Hereditary cancer; Cost analysis.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572015000300332

Hereditary cancer risk assessment: insights and perspectives for the Next-Generation Sequencing era
Provedor de dados: 74
Autores: Gomy,Israel; Diz,Maria Del Pilar Estevez.
Abstract Hereditary cancer risk assessment is a multidisciplinary and dynamic process, with the purpose of estimating probabilities of germline mutations in cancer susceptibility genes and assessing empiric risks of cancer based on personal and family histories, in order to offer clinical and molecular diagnoses and clinical management based on these risks. Genetic tests are available and most of them are reimbursed by insurance companies, although they are generally not covered by the public health systems of developing countries. More recently, molecular diagnosis of hereditary cancer is feasible through next-generation sequencing (NGS) panels. Here we review the benefits and limitations of NGS technologies in the clinical practice.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Next-generation sequencing; Hereditary cancer; Genetic counseling; Risk assessment.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572016000200184

Oncogenetics service and the Brazilian public health system: the experience of a reference Cancer Hospital
Provedor de dados: 74
Autores: Palmero,Edenir I.; Galvão,Henrique C.R.; Fernandes,Gabriela C.; Paula,André E. de; Oliveira,Junea C.; Souza,Cristiano P.; Andrade,Carlos E.; Romagnolo,Luis G.C.; Volc,Sahlua; C. Neto,Maximiliano; Sabato,Cristina; Grasel,Rebeca; Mauad,Edmundo; Reis,Rui M.; Michelli,Rodrigo A.D.
Abstract The identification of families at-risk for hereditary cancer is extremely important due to the prevention potential in those families. However, the number of Brazilian genetic services providing oncogenetic care is extremely low for the continental dimension of the country and its population. Therefore, at-risk patients do not receive appropriate assistance. This report describes the creation, structure and management of a cancer genetics service in a reference center for cancer prevention and treatment, the Barretos Cancer Hospital (BCH). The Oncogenetics Department (OD) of BCH offers, free of charge, to all patients/relatives with clinical criteria, the possibility to perform i) genetic counseling, ii) preventive examinations and iii) genetic...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Oncogenetics; Hereditary cancer; Public health.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572016000200168

Cancer-related worry and risk perception in Brazilian individuals seeking genetic counseling for hereditary breast cancer
Provedor de dados: 74
Autores: Palmero,Edenir Inêz; Campacci,Natalia; Schüler-Faccini,Lavinia; Giugliani,Roberto; Rocha,José Claudio Casali da; Vargas,Fernando Regla; Ashton-Prolla,Patricia.
Abstract In Brazil, the population in general has little knowledge about genetic risks, as well as regarding the role and importance of the Cancer Genetic Counseling (CGC). The goal of this study was to evaluate cancer-related worry and cancer risk perception during CGC sessions in Brazilian women at-risk for hereditary breast cancer. This study was performed in 264 individuals seeking CGC for hereditary breast cancer. Both cancer-affected and unaffected individuals were included. As results, individuals with and without cancer reported different motivations for seeking CGC and undergoing genetic testing. A correlation was observed between age at the first CGC session and age at which the closest relative was diagnosed with cancer. Multivariate analysis...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Hereditary breast cancer; Hereditary cancer; Cancer-related worry; Cancer risk perception; Genetic counselling.
Ano: 2020
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572020000400104