Consulta: subjectFacets:"Herpes simplex virus"
Registros recuperados: 2
Data/hora: 03/06/2024 03:42:51

Antiviral Activities of Sulfated Polysaccharides Isolated from Sphaerococcus coronopifolius (Rhodophytha, Gigartinales) and Boergeseniella thuyoides (Rhodophyta, Ceramiales)
Provedor de dados: Institutional Archive of Ifreme (ArchiMer)
Autores: Bouhlal, Rhimou; Haslin, Camille; Chermann, Jean-claude; Colliec-jouault, Sylvia; Sinquin, Corinne; Simon, Gaelle; Cerantola, Stephane; Riadi, Hassane; Bourgougnon, Nathalie.
Water-soluble sulfated polysaccharides isolated from two red algae Sphaerococcus coronopifolius (Gigartinales, Sphaerococcaceae) and Boergeseniella thuyoides (Ceramiales, Rhodomelaceae) collected on the coast of Morocco inhibited in vitro replication of the Human Immunodeficiency Virus (HIV) at 12.5 mu g/mL. In addition, polysaccharides were capable of inhibiting the in vitro replication of Herpes simplex virus type 1 (HSV-1) on Vero cells values of EC(50) of 4.1 and 17.2 mu g/mL, respectively. The adsorption step of HSV-1 to the host cell seems to be the specific target for polysaccharide action. While for HIV-1, these results suggest a direct inhibitory effect on HIV-1 replication by controlling the appearance of the new generations of virus and...
Tipo: Text
Palavras-chave: Herpes simplex virus; Human immunodeficiency virus; Antiviral activity; Sulfated polysaccharide; S. coronopifolius; B. thuyoides; Chemical composition.
Ano: 2011
URL: http://archimer.ifremer.fr/doc/00060/17120/14631.pdf

Herpes simplex virus ophthalmic disease induced using two different methods of mice inoculation
Provedor de dados: Brazilian Journal of Infectious Diseases
Autores: Pereira,Sílvia Regina Ferreira Gonçalves; Guimarães,Maria Angélica A. M.; V. Neto,Leonardo; Segenreich,Daniel; Varella,Rafael Brandão; Chagas,Vera Lucia Antunes; Câmara,Fernando Portela.
Two different procedures for inoculation of HSV on corneas of BALB/c mice were evaluated. The first was by the use of HSV suspensions directly on the corneas and the other was after corneal scarification. Animals by this later method presented greater morbidity and mortality than those of first group, suggesting that inoculation of HSV without scarification of the cornea should be the method of choice for the study of HSV ophthalmic infection. This model showed also be an efficient experimental system to testing antiviral drugs.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Herpes simplex virus; Ophthalmic disease; Non-traumatic and traumatic inoculation; Murine model.
Ano: 2001
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702001000400004